Project Group Molecular Developmental Neurobiology


Journal Article (51)

  1. 1.
    Narayanan, R.; Pham, L.; Kerimoglu, C.; Watanabe, T.; Hernandez, R. C.; Sokpor, G.; Ulmke, P. A.; Kiszka, K. A.; Tonchev, A. B.; Rosenbusch, J. et al.; Seong, R. H.; Teichmann, U.; Frahm, J.; Fischer, A.; Bonn, S.; Stoykova, A.; Staiger, J. F.; Tuoc, T.: Chromatin remodeling BAF155 subunit regulates the genesis of basal progenitors in developing cortex. iSience 4, pp. 109 - 126 (2018)
  2. 2.
    Nguyen, H.; Kerimoglu, C.; Pirouz, M.; Pham, L.; Kiszka, K. A.; Sokpor, G.; Sakib, M. S.; Rosenbusch, J.; Teichmann, U.; Seong, R. H. et al.; Stoykova, A.; Fischer, A.; Staiger, J. F.; Tuoc, T.: Epigenetic regulation by BAF complexes limits neural stem cell proliferation by suppressing Wnt signaling in late embryonic development. Stem Cell Reports 10 (6), pp. 1734 - 1750 (2018)
  3. 3.
    Doeppner, T. R.; Herz, J.; Bähr, M.; Tonchev, A. B.; Stoykova, A.: Zbtb20 regulates developmental neurogenesis in the olfactory bulb and gliogenesis after adult brain injury. Molecular Neurobiology (2018)
  4. 4.
    Tuoc, T.; Dere, E.; Radyushkin, K.; Pham, L.; Nguyen, H.; Tonchev, A. B.; Sun, G.; Ronnenberg, A.; Shi, Y.; Staiger, J. F. et al.; Ehrenreich, H.; Stoykova, A.: Ablation of BAF170 in developing and postnatal dentate gyrus affects neural stem cell proliferation, differentiation, and learning. Molecular Neurobiology 54 (6), pp. 4618 - 4635 (2017)
  5. 5.
    Pavlakis, E.; Tonchev, A. B.; Kaprelyan, A.; Enchev, Y.; Stoykova, A.: Interaction between transcription factors PAX6/PAX6-5a and specific members of miR-183-96-182 cluster, may contribute to glioma progression in glioblastoma cell lines. Oncology Reports 37 (3), pp. 1579 - 1592 (2017)
  6. 6.
    Bachmann, C.; Nguyen, H.; Rosenbusch, J.; Pham, L.; Rabe, T.; Patwa, M.; Sokpor, G.; Seong, R. H.; Ashery-Padan, R.; Mansouri, A. et al.; Stoykova, A.; Staiger, J. F.; Tuoc, T.: mSWI/SNF (BAF) complexes are indispensable for the neurogenesis and development of embryonic olfactory epithelium. PLoS Genetics (2016)
  7. 7.
    Tonchev, A. B.; Tuoc, T. C.; Rosenthal, E. H.; Studer, M.; Stoykova, A.: Zbtb20 modulates the sequential generation of neuronal layers in developing cortex. Molecular Brain (2016)
  8. 8.
    Nguyen, H.; Sokpor, G.; Pham, L.; Rosenbusch, J.; Stoykova, A.; Staiger, J. F.; Tuoc, T.: Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development. Cell Cycle 15 (10), pp. 1317 - 1324 (2016)
  9. 9.
    Narayanan, R.; Pirouz, M.; Kerimoglu, C.; Pham, L.; Wagener, R. J.; Kiszka, K. A.; Rosenbusch, J.; Seong, R. H.; Kessel, M.; Fischer, A. et al.; Stoykova, A.; Staiger, J. F.; Tuoc, T. C.: Loss of BAF (mSWI/SNF) complexes causes global transcriptional and chromatin state changes in forebrain development. Cell Reports 13 (9), pp. 1842 - 1854 (2015)
  10. 10.
    Tylkowski, M. A.; Yang, K.; Hoyer-Fender, S.; Stoykova, A.: Pax6 controls centriole maturation in cortical progenitors through Odf2. Cellular and Molecular Life Sciences 72 (9), pp. 1795 - 1809 (2015)
  11. 11.
    Kumarswamy, R.; Volkmann, I.; Beermann, J.; Napp, L. C.; Jabs, O.; Bhayadia, R.; Melk, A.; Ucar, A.; Chowdhury, K.; Lorenzen, J. M. et al.; Gupta, S. K.; Batkai, S.; Thum, T.: Vascular importance of themiR-212/132 cluster. European Heart Journal 35 (45), pp. 3224 - 3231 (2014)
  12. 12.
    Yazdankhah, M.; Farioli-Vecchioli, S.; Tonchev, A. B.; Stoykova, A.; Cecconi, F.: The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone. Cell Death and Disease (2014)
  13. 13.
    Tuoc, T.C.; Pavlakis, E.; Tylkowski, M. A.; Stoykova, A.: Control of cerebral size and thickness. Cellular and Molecular Life Sciences 71 (17), pp. 3199 - 3218 (2014)
  14. 14.
    Ucar, A.; Erikci, E.; Ucar, O.; Chowdhury, K.: miR-212 and miR-132 are dispensable for mouse mammary gland development. Nature Genetics 46 (8), pp. 804 - 805 (2014)
  15. 15.
    Paul, V.; Tonchev, A. B.; Henningfeld, K. A.; Pavlakis, E.; Rust, B.; Pieler, T.; Stoykova, A.: Scratch2 modulates neurogenesis and cell migration through antagonism of bHLH proteins in the developing neocortex. Cerebral Cortex 24 (3), pp. 754 - 772 (2014)
  16. 16.
    Tuoc, T. C.; Narayanan, R.; Stoykova, A.: BAF chromatin remodeling complex: Cortical size regulation and beyond. Cell Cycle 12 (18), pp. 2953 - 2959 (2013)
  17. 17.
    Zembrzycki, A.; Chou, S. J.; Ashery-Padan, R.; Stoykova, A.; O'Leary, D. D. M.: Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits. Nature Neuroscience 16 (8), pp. 1060 - 1067 (2013)
  18. 18.
    Tuoc, T.C.; Boretius, S.; Sansom, S. N.; Pitulescu, M. E.; Frahm, J.; Livesey, F. J.; Stoykova, A.: Chromatin regulation by BAF170 controls cerebral cortical size and thickness. Developmental Cell 25 (3), pp. 256 - 269 (2013)
  19. 19.
    Rosenthal, E. H.; Tonchev, A. B.; Stoykova, A.; Chowdhury, K.: Regulation of archicortical arealization by the transcription factor Zbtb20. Hippocampus 22 (11), pp. 2144 - 2156 (2012)
  20. 20.
    Ucar, A.; Gupta, S. K.; Fiedler, J.; Erikci, E.; Kardasinski, M.; Batkai, S.; Dangwal, S.; Kumarswarmy, R.; Bang, C.; Holzmann, A. et al.; Remke, J.; Caprio, M.; Jentzsch, C.; Engelhardt, S.; Geisendorf, S.; Glas, C.; Hofmann, T. G.; Nessling, M.; Richter, K.; Schiffer, M.; Carrier, L.; Napp, L. C.; Bauersachs, J.; Chowdhury, K.; Thum, T.: The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nature Communications (2012)
  21. 21.
    Szabo, N. E.; Zhao, T. Y.; Cankaya, M.; Stoykova, A.; Zhou, X. L.; Alvarez-Bolado, G.: Interaction between axons and specific populations of surrounding cells is indispensable for collateral formation in the mammillary system. PLoS One (2011)
  22. 22.
    Ucar, A.; Vafaizadeh, V.; Jarry, H.; Fiedler, J.; Klemmt, P. A.; Thum, T.; Groner, B.; Chowdhury, K.: miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development. Nature Genetics 42 (12), pp. 1101 - 1108 (2010)
  23. 23.
    Tuoc, T. C.; Stoykova, A.: Roles of the ubiquitin-proteosome system in neurogenesis. Cell Cycle 9 (16), pp. 3174 - 3180 (2010)
  24. 24.
    Boretius, S.; Michaelis, T.; Tammer, R.; Ashery-Padan, R.; Frahm, J.; Stoykova, A.: In vivo MRI of altered brain anatomy and fiber connectivity in adult Pax6 deficient mice. Cerebral Cortex 19 (12), pp. 2838 - 2847 (2009)
  25. 25.
    Davis, N.; Yoffe, C.; Raviv, S.; Antes, R.; Berger, J.; Holzmann, S.; Stoykova, A.; Overbeek, P. A.; Tamm, E. R.; Ashery-Padan, R.: Pax6 dosage requirements in iris and ciliary body differentiation. Developmental Biology 333 (1), pp. 132 - 142 (2009)
  26. 26.
    Tuoc, T. C.; Radyushkin, K.; Tonchev, A. B.; Pinon, M. C.; Ashery-Padan, R.; Molnar, Z.; Davidoff, M. S.; Stoykova, A.: Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. Journal of Neuroscience 29 (26), pp. 8335 - 8349 (2009)
  27. 27.
    Pinon, M. C.; Tuoc, T. C.; Ashery-Padan, R.; Molnar, Z.; Stoykova, A.: Altered molecular regionalization and normal thalamocortical connections in cortex-specific Pax6 knock-out mice. The Journal of Neuroscience 28 (35), pp. 8724 - 8734 (2008)
  28. 28.
    Tuoc, T. C.; Stoykova, A.: Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin–proteosome system. Genes & Development 22 (14), pp. 1972 - 1986 (2008)
  29. 29.
    Tuoc, T. C.; Stoykova, A.: Er81 is a downstream target of Pax6 in cortical progenitors. BMC Developmental Biology, 8:23 (2008)
  30. 30.
    Cecconi, F.; Di Bartolomeo, S.; Nardacci, R.; Fuoco, C.; Corazzari, M.; Giunta, L.; Romagnoli, A.; Stoykova, A.; Chowdhury, K.; Fimia, G. M. et al.; Piacentini, M.: A novel role for autophagy in neurodevelopment. Autophagy 3 (5), pp. 506 - 508 (2007)
  31. 31.
    Remedios, R.; Huilgol, D.; Saha, B.; Hari, P.; Bhatnagar, L.; Kowalczyk, T.; Hevner, R. V.; Suda, Y.; Aizawa, S.; Ohshima, T. et al.; Stoykova, A.; Tole, S.: A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nature Neuroscience 10 (9), pp. 1141 - 1150 (2007)
  32. 32.
    Muehlfriedel, S.; Kirsch, F.; Gruss, P.; Chowdhury, K.; Stoykova, A.: Novel genes differentially expressed in cortical regions during late neurogenesis. European Journal of Neuroscience 26 (1), pp. 33 - 50 (2007)
  33. 33.
    Fimia, G. M.; Stoykova, A.; Romagnoli, A.; Giunta, L.; Di Bartolomeo, S.; Nardacci, R.; Corazzari, M.; Fuoco, C.; Ucar, A.; Schwartz, P. et al.; Gruss, P.; Piacentini, M.; Chowdhury, K.; Cecconi, F.: Ambra1 regulates autophagy and development of the nervous system. Nature 447 (7148), pp. 1121 - 1125 (2007)
  34. 34.
    Zembrzycki, A.; Griesel, G.; Stoykova, A.; Mansouri, A.: Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain. Neural Development, 2:8 (2007)
  35. 35.
    Berger, J.; Berger, S.; Tuoc, T. C.; D'Amelio, M. D.; Cecconi, F.; Gorski, J. A.; Jones, K.; Gruss, P.; Stoykova, A.: Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis. Development 134 (7), pp. 1311 - 1322 (2007)
  36. 36.
    Chang, Y. S.; Stoykova, A.; Chowdhury, K.; Gruss, P.: Graded expression of Zfp462 in the embryonic mouse cerebral cortex. Gene Expression Patterns 7 (4), pp. 405 - 412 (2007)
  37. 37.
    Vogel, T.; Stoykova, A.; Gruss, P.: Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes. Developmental Dynamics 235 (9), pp. 2574 - 2585 (2006)
  38. 38.
    Guillemot, F.; Molnar, Z.; Tarabykin, V.; Stoykova, A.: Molecular mechanisms of cortical differentiation. European Journal of Neuroscience 23 (4), pp. 857 - 868 (2006)
  39. 39.
    Muehlfriedel, S.; Kirsch, F.; Gruss, P.; Stoykova, A.; Chowdhury, K.: A roof plate-dependent enhancer controls the expression of Homeodomain only protein in the developing cerebral cortex. Developmental Biology 283 (2), pp. 522 - 534 (2005)
  40. 40.
    Tole, S.; Remedios, R.; Saha, B.; Stoykova, A.: Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex. Journal of Neuroscience 25 (10), pp. 2753 - 2760 (2005)
  41. 41.
    Berger, J.; Eckert, S.; Scardigli, R.; Guillemot, F.; Gruss, P.; Stoykova, A.: E1-Ngn2/Cre is a new line for regional activation of Cre recombinase in the developing CNS. Genesis 40 (4), pp. 195 - 199 (2004)
  42. 42.
    Haubst, N.; Berger, J.; Radjendirane, V.; Graw, J.; Favor, J.; Saunders, G. F.; Stoykova, A.; Goetz, M.: Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. Development 131 (24), pp. 6131 - 6140 (2004)
  43. 43.
    Nayernia, K.; Vauti, F.; Meinhardt, A.; Cadenas, C.; Schweyer, S.; Meyer, B.; Schwandt, I.; Chowdhury, K.; Engel, W.; Arnold, H. H.: Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility. The Journal of Biological Chemistry 278 (48), pp. 48377 - 48385 (2003)
  44. 44.
    Vrontou, S.; Petrou, P.; Meyer, B.; Galanopoulos, V. K.; Imai, K.; Yanagi, M.; Chowdhury, K.; Scrambler, P. J.; Chalepakis, G.: Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice. Nature Genetics 34 (2), pp. 209 - 214 (2003)
  45. 45.
    Baeumer, N.; Marquardt, T.; Stoykova, A.; Spieler, D.; Treichel, D.; Ashery-Padan, R.; Gruss, P.: Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development 130 (13), pp. 2903 - 2915 (2003)
  46. 46.
    Stoykova, A.; Hatano, O.; Gruss, P.; Goetz, M.: Increase of reelin-positive cells in the marginal zone of Pax6-mutant mouse cortex. Cerebral Cortex 13 (6), pp. 560 - 571 (2003)
  47. 47.
    Jones, L.; Lopez-Bendito, G.; Gruss, P.; Stoykova, A.; Molnar, Z.: Pax6 is required for the normal development of the forebrain axonal connections. Development 129 (21), pp. 5041 - 5052 (2002)
  48. 48.
    Baeumer, N.; Marquardt, T.; Stoykova, A.; Ashery-Padan, R.; Chowdhury, K.; Gruss, P.: Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle. Development 129 (19), pp. 4535 - 4545 (2002)
  49. 49.
    Muzio, L.; DiBenedetto, B.; Stoykova, A.; Boncinelli, E.; Gruss, P.; Mallamaci, A.: Conversion of cerebral cortex into basal ganglia in Emx2-/- Pax6sey/sey double-mutant mice. Nature Neuroscience 5 (8), pp. 737 - 745 (2002)
  50. 50.
    Moreno, S.; Ferraro, E.; Eckert, S.; Cecconi, F.: Apaf1 reduced expression levels generate a mutant phenotype in adult brain and skeleton. Cell Death and Differentiation 9 (3), pp. 340 - 342 (2002)
  51. 51.
    Muzio, L.; DiBenedetto, B.; Stoykova, A.; Boncinelli, E.; Gruss, P.; Mallamaci, A.: Emx2 and Pax6 control regionalization of the pre-neuronogenic cortical primordium. Cerebral Cortex 12 (2), pp. 129 - 139 (2002)
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