Forschungsgruppe Ribosomendynamik

Publikationen

Zeitschriftenartikel (29)

  1. 1.
    Mercier, E.; Holtkamp, W.; Rodnina, M. V.; Wintermeyer, W.: Signal recognition particle binds to translating ribosomes before emergence of a signal anchor sequence. Nucleic Acids Research 45 (20), S. 11858 - 11866 (2017)
  2. 2.
    Ranjan, A.; Mercier, E.; Bhatt, A.; Wintermeyer, W.: Signal recognition particle prevents N-terminal processing of bacterial membrane proteins. Nature Communications (2017)
  3. 3.
    Draycheva, A.; Bornemann, T.; Ryazanov, S.; Lakomek, N. A.; Wintermeyer, W.: The bacterial SRP receptor, FtsY, is activated on binding to the translocon. Molecular Microbiology 102 (1), S. 152 - 167 (2016)
  4. 4.
    Lakomek, N. A.; Draycheva, A.; Bornemann, T.; Wintermeyer, W.: Electrostatics and intrinsic disorder drive translocon binding of the SRP receptor FtsY. Angewandte Chemie International Edition 55 (33), S. 9544 - 9547 (2016)
  5. 5.
    Rodnina, M. V.; Wintermeyer, W.: Protein elongation, co-translational folding and targeting. Journal of Molecular Biology 428 (10, P. B), S. 2165 - 2185 (2016)
  6. 6.
    Belardinelli, R.; Sharma, H.; Caliskan, N.; da Cunha, C. E. L.; Peske, F.; Wintermeyer, W.; Rodnina, M. V.: Choreography of molecular movements during ribosome progression along mRNA. Nature Structural and Molecular Biology 23 (4), S. 342 - 348 (2016)
  7. 7.
    Belardinelli, R.; Sharma, H.; Peske, F.; Wintermeyer, W.; Rodnina, M. V.: Translocation as continuous movement through the ribosome. RNA Biology 13 (12), S. 1197 - 1203 (2016)
  8. 8.
    Kuhn, P.; Draycheva, A.; Vogt, A.; Petriman, N. A.; Sturm, L.; Drepper, F.; Warscheid, B.; Wintermeyer, W.; Koch, H. G.: Ribosome binding induces repositioning of the signal recognition particle receptor on the translocon. Journal of Cell Biology (2015)
  9. 9.
    Adio, S.; Senyushkina, T.; Peske, F.; Fischer, N.; Wintermeyer, W.; Rodnina, M. V.: Fluctuations between multiple EF-G-induced chimeric tRNA states during translocation on the ribosome. Nature Communications (2015)
  10. 10.
    Ge, Y.; Draycheva, A.; Bornemann, T.; Rodnina, M. V.; Wintermeyer, W.: Lateral opening of the bacterial translocon on ribosome binding and signal peptide insertion. Nature Communications (2014)
  11. 11.
    Holtkamp, W.; Wintermeyer, W.; Rodnina, M. V.: Synchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis. BioEssays 36 (10), S. 908 - 918 (2014)
  12. 12.
    Bornemann, T.; Holtkamp, W.; Wintermeyer, W.: Interplay between trigger factor and other protein biogenesis factors on the ribosome. Nature Communications (2014)
  13. 13.
    Holtkamp, W.; da Cunha, C. E. L.; Peske, F.; Konevega, A. L.; Wintermeyer, W.; Rodnina, M. V.: GTP hydrolysis by EF‐G synchronizes tRNA movement on small and large ribosomal subunits. EMBO Journal 33 (9), S. 1073 - 1085 (2014)
  14. 14.
    Peske, F.; Kuhlenkötter, S.; Rodnina, M. V.; Wintermeyer, W.: Timing of GTP binding and hydrolysis by translation termination factor RF3. Nucleic Acids Research 42 (3), S. 1812 - 1820 (2014)
  15. 15.
    da Cunha, C. E. L.; Belardinelli, R.; Peske, F.; Holtkamp, W.; Wintermeyer, W.; Rodnina, M. V.: Dual use of GTP hydrolysis by elongation factor G on the ribosome. Translation 1 (1), e24315 (2013)
  16. 16.
    Holtkamp, W.; Lee, S.; Bornemann, T.; Senyushkina, T.; Rodnina, M. V.; Wintermeyer, W.: Dynamic switch of the signal recognition particle from scanning to targeting. Nature Structural and Molecular Biology 19 (12), S. 1332 - 1337 (2012)
  17. 17.
    Cox, G.; Thompson, G. S.; Jenkins, H. T.; Peske, F.; Savelsbergh, A.; Rodnina, M. V.; Wintermeyer, W.; Homans, S. W.; Edwards, T. A.; O'Neill, A. J.: Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proceedings of the National Academy of Sciences of the United States of America 109 (6), S. 2102 - 2107 (2012)
  18. 18.
    Kuhlenkötter, S.; Wintermeyer, W.; Rodnina, M. V.: Different substrate-dependent transition states in the active site of the ribosome. Nature 476, S. 351 - 354 (2011)
  19. 19.
    Rodnina, M. V.; Wintermeyer, W.: The ribosome as a molecular machine: The mechanism of tRNA–mRNA movement in translocation. Biochemical Society Transactions 39, S. 658 - 662 (2011)
  20. 20.
    Wintermeyer, W.; Rodnina, M. V.: Genauigkeit und Geschwindigkeit der Proteinsynthese. Biospektrum 17 (4), S. 389 - 392 (2011)
  21. 21.
    Milon, P.; Carotti, M.; Konevega, A. L.; Wintermeyer, W.; Rodnina, M. V.; Gualerzi, C. O.: The ribosome-bound initiation factor 2 recruits initiator tRNA to the 30S initiation complex. EMBO Reports 11 (4), S. 312 - 316 (2010)
  22. 22.
    Fischer, N.; Konevega, A. L.; Wintermeyer, W.; Rodnina, M. V.; Stark, H.: Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy. Nature 466 (7304), S. 329 - 333 (2010)
  23. 23.
    Rodnina, M. V.; Wintermeyer, W.: The ribosome goes Nobel. Trends in Biochemical Sciences 35 (1), S. 1 - 5 (2010)
  24. 24.
    Rodnina, M. V.; Wintermeyer, W.: Recent mechanistic insight into eukaryotic ribosomes. Current Opinion in Cell Biology 21 (3), S. 435 - 443 (2009)
  25. 25.
    Savelsbergh, A.; Rodnina, M. V.; Wintermeyer, W.: Distinct functions of elongation factor G in ribosome recycling and translocation. RNA 15 (5), S. 772 - 780 (2009)
  26. 26.
    Buskiewicz, I. A.; Jöckel, J.; Rodnina, M. V.; Wintermeyer, W.: Conformation of the signal recognition particle in ribosomal targeting complexes. RNA 15 (1), S. 44 - 54 (2009)
  27. 27.
    Rodnina, M. V.; Wintermeyer, W.: Das Ribosom: Struktur und Funktionen eines Mega-Ribozyms. Biospektrum 9 (2), S. 138 - 141 (2003)
  28. 28.
    Stark, H.; Rodnina, M. V.; Wieden, H. J.; Zemlin, F.; Wintermeyer, W.; van Heel, M.: Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex. Nature Structural Biology 9 (11), S. 849 - 854 (2002)
  29. 29.
    Stark, H.; Rodnina, M. V.; Wieden, H. J.; Zemlin, F.; Wintermeyer, W.; van Heel, M.: Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex. Nature Structural Biology 9 (11), S. 849 - 854 (2002)

Buch (1)

  1. 30.
    Rodnina, M.; Wintermeyer, W.; Green, R. (Hg.): Ribosomes: Structure, Function, and Dynamics. Springer, Wien (2011), IX, 442 S.

Buchkapitel (6)

  1. 31.
    Bornemann, T.; Holtkamp, W.; Wintermeyer, W.: Nascent peptide-induced signaling from the exit tunnel to the outside of the ribosome. In: Regulatory nascent polypeptides, S. 87 - 97 (Hg. Ito, K.). Springer, Tokyo (2014)
  2. 32.
    Peske, F.; Wintermeyer, W.: Antibiotics inhibiting the translocation step of protein elongation on the ribosome. In: Antibiotics: Targets, Mechanisms and Resistance, S. 491 - 508 (Hg. Gualerzi, C. O.; Brandi, L.; Fabbretti, A.; Pon, C. L.). Wiley VCH, Weinheim (2013)
  3. 33.
    Rodnina, M. V.; Wintermeyer, W.: Rapid kinetic analysis of protein synthesis. In: Biophysical approaches to translational control of gene expression, S. 119 - 139 (Hg. Dinman, J. D.). Springer, New York (2013)
  4. 34.
    Wintermeyer, W.: Translocation on the ribosome. In: Encyclopedia of biophysics, Bd. 5; S - Z, S. 2650 - 2655 (Hg. Roberts, G. C. K.). Springer, Heidelberg (2013)
  5. 35.
    Rodnina, M.: Mechanisms of decoding and peptide bond formation. In: Ribosomes: Structure, Function, and Dynamics, S. 199 - 212. Springer, Wien (2011)
  6. 36.
    Wintermeyer, W.; Savelsbergh, A.; Konevega, A. L.; Peske, F.; Katunin, V.; Semenkov, Y.; Fischer, N.; Stark, H.; Rodnina, M.: Functions of elongation factor G in translocation and ribosome recycling. In: Ribosomes: Structure, Function, and Dynamics, S. 329 - 338. Springer, Wien (2011)
 
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