The listings of 2011 and 2012 are incomplete.Publications Max Planck Research Group Wolfgang Fischle
2011
Jeltsch, A. and W. Fischle:
Molecular epigenetics: Connecting human biology and disease with little marks.
ChemBioChem 12, 183-184 (2011)
Koester-Eiserfunke, N. and W. Fischle:
H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.
PLoS Genetics 7, e1002017 (2011)
Mosch, K., H. Franz, S. Soeroes, P. B. Singh and W. Fischle:
HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats.
PLoS ONE 6, e15894 (2011)
Nikolov, M., A. Stützer, K. Mosch, A. Krasauskas, S. Sörös, H. Stark, H. Urlaub and W. Fischle:
Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns.
Molecular and Cellular Proteomics 10, DOI: 10.1074/mcp.M110.005371 (2011)
Oppikofer, M., S. Kueng, F. Martino, S. Soeroes, S. M. Hancock, J. W. Chin, W. Fischle and S. M. Gasser:
A dual role of H4K16 acetylation in the establishment of yeast silent chromatin.
EMBO Journal 30, 2610-2621 (2011)
Schmitges, F. W., A. B. Prusty, M. Faty, A. Stützer, G. M. Lingaraju, J. Aiwazian, R. Sack, D. Hess, L. Li, S. Zhou, R. D. Bunker, U. Wirth, T. Bouwmeester, A. Bauer, N. Ly-Hartig, K. Zhao, H. Chan, J. Gu, H. Gut, W. Fischle, J. Mueller and N. H. Thomae:
Histone methylation by PRC2 is inhibited by active chromatin marks.
Molecular Cell 42, 330-341 (2011)
Seeliger, D., S. Sörös, R. Klingberg, D. Schwarzer, H. Grubmüller and W. Fischle:
Quantitative assessment of protein interaction with methyl-lysine analogues by hybrid computational and experimental approaches.
ACS Chemical Biology DOI: 10.1021/cb200363r (2011)
Stojic, L., Z. Jasencakova, C. Prezioso, A. Stützer, B. Bodega, D. Pasini, R. Klingberg, C. Mozzetta, R. Margueron, P. L. Puri, D. Schwarzer, K. Helin, W. Fischle and V. Orlando:
Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells.
Epigenetics and Chromatin 4, 16 (2011)
2010
Franz, H.:
Functional characterization of CDY family proteins and their role in recognition of the heterochromatic histone H3K9me3 modification.
Universität Göttingen, Göttingen (2010)
Grote, M., E. Wolf, C. L. Will, I. Lemm, D. E. Agafonov, A. Schomburg, W. Fischle, H. Urlaub and R. Luehrmann:
Molecular architecture of the human Prp19/CDC5L complex.
Molecular and Cellular Biology 30, 2105-2119 (2010)
Koester-Eiserfunke, N.:
Characterization of LIN-61 methyl mark binding and its function in C. elegans vulva development.
Tsai, W. W., Z. Wang, T. T. Yiu, K. C. Akdemir, W. Xia, S. Winter, C. Y. Tsai, X. Shi, D. Schwarzer, W. Plunkett, B. Aronow, O. Gozani, W. Fischle, M. C. Hung, D. J. Patel and M. C. Barton:
TRIM24 links a non-canonical histone signature to breast cancer.
Nature 468, 927-932 (2010)
Winter, S. and W. Fischle:
Epigenetic markers and their cross-talk.
Essays in Biochemistry 48, 45-61 (2010)
Zhang, Y., R. Jurkowska, S. Soeroes, A. Rajavelu, A. Dhayalan, I. Bock, P. Rathert, O. Brandt, R. Reinhardt, W. Fischle and A. Jeltsch:
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail.
Nucleic Acids Research 38, 4246-4253 (2010)
2009
Fischle, W.:
Tip60-ing the balance in DSB repair.
Nature Cell Biology 11, 1279-1281 (2009)
Franz, H., K. Mosch, S. Soeroes, H. Urlaub and W. Fischle:
Multimerization and H3K9me3 binding is required for CDYL1b heterochromatin association.
The Journal of Biological Chemistry 284, 35049-35059 (2009)
Somel, M., H. Franz, Z. Yan, A. Lorenc, S. Guo, T. Giger, J. Kelso, B. Nickel, M. Dannemann, S. Bahn, M. J. Webster, C. S. Weickert, M. Lachmann, S. Paabo and P. Khaitovich:
Transcriptional neoteny in the human brain.
Proceedings of the National Academy of Sciences of the United States of America 106, 5743-5748 (2009)
Wirth, M. and M. A. Jedrusik-Bode:
Interplay between histone deacetylase SIR-2, linker histone H1 and histone methyltransferases in heterochromatin formation.
Epigenetics 4, 353-356 (2009)
Wirth, M., F. Paap, W. Fischle, D. Wenzel, D. E. Agafonov, T. R. Samatov, J. R. Wisniewski and M. Jedrusik-Bode:
HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in C. elegans germline.
Molecular and Cellular Biology 29, 3700-3709 (2009)
Zielinska, D. F., F. Gnad, M. Jedrusik-Bode, J. R. Wiesniwski and M. Mann:
Caenorhabditis elegans has a phosphoproteome atypical for metazoans that is enriched in developmental and sex determination proteins.
Journal of Proteome Research 8, 4039-4049 (2009)
2008
Fischle, W.:
Talk is cheap-cross-talk in establishment, maintenance, and readout of chromatin modifications.
Genes and Development 22, 3375-3382 (2008)
Fischle, W., H. Franz, S. A. Jacobs, C. D. Allis and S. Khorasanizadeh:
Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs.
The Journal of Biological Chemistry 283, 19626-19635 (2008)
Gelato, K. A. and W. Fischle:
Role of histone modifications in defining chromatin structure and function.
Biological Chemistry 389, 353-363 (2008)
Harder, B., A. Schomburg, R. Pflanz, K. Kuestner, N. Gerlach and R. Schuh:
TEV protease-mediated cleavage in Drosophila as a tool to analyze protein functions in living organisms.
BioTechniques 44, 765-772 (2008)
Kalakonda, N., W. Fischle, P. Boccuni, N. Gurvich, R. Hoya-Arias, X. Zhao, Y. Miyata, D. Magrogan, J. Zhang, J. K. Sims, J. C. Rice and S. D. Nimer:
Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1.
Oncogene 27, 4293-4304 (2008)
Winter, S., W. Fischle and C. Seiser:
Modulation of 14-3-3 interaction with phosphorylated histone H3 by combinatorial modification patterns.
Cell Cycle 7, 1336-1342 (2008)
Winter, S., E. Simboeck, W. Fischle, G. Zupkovitz, I. Dohnal, K. Mechtler, G. Ammerer and C. Seiser:
14-3-3 Proteins recognize a histone code at histone H3 and are required for transcriptional activation.
The EMBO Journal 27, 88-99 (2008)
Zhang, K., K. Mosch, W. Fischle and S. I. Grewal:
Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin.
Nature Structural and Molecular Biology 15, 381-388 (2008)
2007
Grimm, C., A. G. de Ayala Alonso, V. Rybin, U. Steuerwald, N. Ly-Hartig, W. Fischle, J. Mueller and C. W. Mueller:
Structural and functional analyses of methyl-lysine binding by te malignant brain tumour repeat protein Sex comb on midleg.
EMBO Reports 8, 1031-1037 (2007)
Jedrusik, M. and E. Schulze:
Linker histone HIS-24 (H1.1) cytoplasmic retention promotes germ line development and influences histone H3 methylation in Caenorhabditis elegans.
Molecular and Cellular Biology 27, 2229-2239 (2007)
Li, H., W. Fischle, W. Wang, E. M. Duncan, L. Liang, S. Murakami-Ishibe, C. D. Allis and D. J. Patel:
Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger.
Molecular Cell 28, 677-691 (2007)
2006
Dormann, H. L., B. S. Tseng, C. D. Allis, H. Funabiki and W. Fischle:
Dynamic regulation of effector protein binding to histone modifications: The biology of HP1 switching.
Cell Cycle 5, 2842-2851 (2006)
Klymenko, T., B. Papp, W. Fischle, T. Kocher, M. Schelder, C. Fritsch, B. Wild, M. Wilm and J. Mueller:
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities.
Genes & Development 20, 1110-1122 (2006)
2005
Fischle, W., B. S. Tseng, H. L. Dormann, B. M. Ueberheide, B. A. Garcia, J. Shabanowitz, D. F. Hunt, H. Funabiki and C. D. Allis:
Regulations of HP1-chromatin binding by histone H3 methylation and phosphorylation.
Nature 438, 1116-1122 (2005)
Fischle, W.:
In nucleo enzymatic assays for the identification and characterization of histone modifying activities.
Methods 36, 362-367 (2005)
Yamada, T., W. Fischle, C. D. Allis and S. I. S. Grewal:
The nucleation and maintenance of
heterochromatin by a histone deacetylase in fission yeast.
Molecular Cell 20, 173-185 (2005)
2004
Jacobs, S. A., W. Fischle and S. Khorasanizadeh:
Assays for the determination of structure and dynamics of the interaction of the chromodomain with histone peptides.
Methods in Enzymology 376, 131-148 (2004)
Wang, Y., W. Fischle, W. Cheung, S. Jabobs, S. Khorasanizadeh and C. D. Allis:
Beyond the double helix: writing and reading the histone code.
Novartis Foundation Symposium 259, 3-17 (2004)
2003
Dequiedt, F., H. Kasler, W. Fischle, V. Kiermer, M. Weinstein, B. G. Herndier and E. Verdin:
HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis.
Immunity 18, 687-698 (2003)
Fischle, W., Y. Wang and C. D. Allis:
Histone and chromatin cross-talk.
Current Opinion in Cell Biology 15, 172-183 (2003)
Fischle, W., Y. Wang and C. D. Allis:
Binary switches and modification cassettes in histone biology and beyond.
Nature 425, 475-479 (2003)
Fischle, W., Y. Wang, S. A. Jacobs, Y. Kim, C. D. Allis and S. Khorasanizadeh:
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb
and HP1 chromodomains.
Genes & Development 17, 687-698 (2003)
Verdin, E., F. Dequiedt, W. Fischle, R. Frye, B. Marshall and B. North:
Measurement of mammalian histone deacetylase activity.
Methods in Enzymology 376, 180-196 (2003)
2002
Fischle, W., F. Dequiedt, M. J. Hendzel, M. G. Guenther, M. A. Lazar, W. Voelter and E. Verdin:
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
Molecular Cell 9, 45-57 (2002)
Murphy, J. C., W. Fischle, E. Verdin and J. H. Sinclair:
Control of cytomegalovirus lytic gene expression by histone acetylation.
EMBO Journal 21, 1112-1120 (2002)
2001
Chen, L. F., W. Fischle, E. Verdin and W. C. Greene:
Duration of nuclear NF-kappaB action regulated by reversible acetylation.
Science 293, 1653-1657 (2001)
Fischle, W., F. Dequiedt, M. Fillion, M. J. Hendzel, W. Voelter and E. Verdin:
Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.
The Journal of Biological Chemistry 276, 35826-35835 (2001)
Fischle, W., V. Kiermer, F. Dequiedt and E. Verdin:
The emerging role of class II histone deacetylases.
Biochemistry & Cell Biology 79, 337-348 (2001)
Kruhlak, M. J., M. J. Hendzel, W. Fischle, N. R. Bertos, S. Hameed, X. J. Yang, E. Verdin and D. P. Bazett-Jones:
Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin.
The Journal of Biological Chemistry 276, 38307-38319 (2001)
2000
Guenther, M. G., W. S. Lane, W. Fischle, E. Verdin, M. A. Lazar and R. Shiekhattar:
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
Genes & Development 14, 1048-1057 (2000)
Huynh, K. D., W. Fischle, E. Verdin and V. J. Bardwell:
BCoR, a novel corepressor involved in BCL-6 repression.
Genes & Development 14, 1810-1823 (2000)
Kruhlak, M. J., M. A. Lever, W. Fischle, E. Verdin, D. P. Bazett-Jones and M. J. Hendzel:
Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments.
The Journal of Biological Chemistry 150, 41-51 (2000)
Tenidis, K., M. Waldner, J. Bernhagen, W. Fischle, M. Bergmann, M. Weber, M. L. Merkle, W. Voelter, H. Brunner and A. Kapurniotu:
Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties.
Journal of Molecular Biology 295, 1055-1071 (2000)
1999
Fischle, W., S. Emiliani, M. J. Hendzel, T. Nagase, N. Nomura, W. Voelter and E. Verdin:
A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p.
The Journal of Biological Chemistry 274, 11713-11720 (1999)
Ott, M., M. Schnolzer, J. Garnica, W. Fischle, S. Emiliani, H. R. Rackwitz and E. Verdin:
Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity.
Current Biology 9, 1489-1492 (1999)
1998
Emiliani, S., W. Fischle, C. Van Lint, Y. Al-Abed and E. Verdin:
Characterization of a human RPD3 ortholog, HDAC3.
Proceedings of the National Academy of Sciences of the United States of America 95, 2795-2800 (1998)
Emiliani, S., W. Fischle, M. Ott, C. Van Lint, C. A. Amella and E. Verdin:
Mutations in the tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell line.
Journal of Virology 72, 1666-1670 (1998)
1996
Emiliani, S., C. Van Lint, W. Fischle, P. Paras, M. Ott and J. Brady:
A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency.
Proceedings of the National Academy of Sciences of the United States of America 93, 6377-6381 (1996)