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| Research Group Mansouri |
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Molecular Cell Differentiation
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Studying the molecular mechanisms controlling cell fate destiny and diversity is of fundamental interest for understanding pathological processes and diseases. We are using mouse genetics to study the role of transcription factors during cell differentiation in the endocrine pancreas and in the ventral midbrain.
In the pancreas, we are interested in molecules that control the endocrine cell subtype specification. In addition, we are studying animal models to uncover molecular pathways promoting beta-cell regeneration in the adult pancreas.
In the midbrain the specification of dopaminergic neurons is under the control of several transcription and secreted factors. Specifically, we want to identify factors that interact with Lmx1 a/b in order to promote the generation of functionally distinct dopaminergic neuron populations.
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Ahmed Mansouri
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© 2012, Max Planck Institute for Biophysical Chemistry, Göttingen |
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