Further information

Department of Molecular Biology Seminar Series

10237 1520428008

Department of Molecular Biology Seminar Series: The mysterious world of Pol II CTD kinases

  • Date: Mar 15, 2018
  • Time: 13:00 - 14:00
  • Speaker: Shona Murphy
  • Sir William Dunn School of Pathology, University of Oxford
  • Location: Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
  • Room: Tower IV, Seminar Room, 2nd Floor
  • Host: Prof. Dr. Patrick Cramer
  • Contact: office.cramer@mpibpc.mpg.de
The carboxyl-terminal domain (CTD) of RNA polymerase II (pol II) is subject to multiple dynamic modifications during the transcription cycle, including phosphorylation by kinases. These CTD kinases are important for co-transcriptional RNA processing and control of elongation of transcription. We have been investigating the effects of short term inhibition of CTD kinases on transcription and CTD phosphorylation by mNET-seq and have uncovered new connections between transcription and RNA processing.
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