Horizons in Molecular Biology 2017: Regulation of pluripotency in human embryos

Horizons in Molecular Biology 2017

  • Datum: 11.09.2017
  • Uhrzeit: 15:30 - 16:15
  • Vortragende(r): Kathy Niakan
  • Francis Crick Institute
  • Ort: Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
  • Raum: Manfred Eigen Hall
  • Gastgeber: Horizons in Molecular Biology
  • Kontakt: participants.horizons@mpibpc.mpg.de
Opening talk of the 14th annual Horizons in Molecular Biology International PhD Symposium
During early human development totipotent zygotes diverge into pluripotent embryonic cells, which form the fetus, and extra-embryonic cells, which contribute to the placenta and yolk sac. Understanding the molecular mechanisms that regulate pluripotency in human embryos and how is it disengaged during cellular differentiation is of fundamental biological importance. Using single-cell RNA-sequencing of human and mouse embryos we have elucidated conserved transcriptional programs along with those that are human-specific. Through the use of genome editing and modulation of signalling we are uncovering the molecular mechanisms that regulate the establishment and maintenance of pluripotency in human embryos. By uncovering the molecular basis of these early cell lineage decisions we underscore their significant clinical implications for infertility, miscarriages, developmental disorders and therapeutic applications of stem cells.

Free registration at http://www.horizons.uni-goettingen.de
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