"Synaptic vesicle exocytosis: Why synaptotagmin catalyzes “fast” membrane fusion (and SNAREs do not)"
- Datum: 16.05.2017
- Uhrzeit: 09:00 - 10:00
- Vortragende(r): Cameron Gundersen
- Department of Molecular & Medical Pharmacology, UCLA School of Medicine
- Ort: Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
- Raum: Large Seminar Room, Administration Building
- Gastgeber: Reinhard Jahn
- Kontakt: office.jahn@mpibpc.mpg.de
This seminar will address a recent hypothesis in which synaptotagmin 1 (or, 2)
functions as a catalyst for exocytotic membrane fusion at nerve terminals. This
model departs from most current scenarios which envision a direct role for
SNAREs in the membrane fusion sequence. Instead, I will summarize how two
structural elements of synaptotagmin can be combined to serve as templates
for the fusion event. The talk will conclude with a brief summary of recent
electron microscopic data which are compatible with this “synaptotagmin-only”
model and are difficult to reconcile with SNARE-based proposals.
functions as a catalyst for exocytotic membrane fusion at nerve terminals. This
model departs from most current scenarios which envision a direct role for
SNAREs in the membrane fusion sequence. Instead, I will summarize how two
structural elements of synaptotagmin can be combined to serve as templates
for the fusion event. The talk will conclude with a brief summary of recent
electron microscopic data which are compatible with this “synaptotagmin-only”
model and are difficult to reconcile with SNARE-based proposals.