Welcome to GO-Cluster!


GO-Cluster is an executable program for Windows 98/2000/NT/XP. The software aims on the visual interpretation of microarray data. An exemplary screenshot is shown in Figure 1. GO-Cluster uses the tree structure of the Gene Ontology-database as a framework for numerical clustering, thus allowing a simple visualization of gene expression data at various levels of the ontology tree.

Figure 1: screenshot of the GO-Cluster main screen.
Figure 1: A typical view of the GO-Cluster screen (for detailed explanation, see the help file).

You may download the program (compressed ZIP-file), download exemplary user files ("gene directory"-, "UniqID"- and data-files, compressed ZIP-file), see the help file (comes also together with the program), learn how to interpret GO-Cluster output or contact the author.

Download the program
The program comes as compressed ZIP-file that contains the Windows 98/2000/NT/XP executable, supplementary binary files, the help file and a GO-Cluster compatible version of the Gene Ontology-database (Release March 2003). Download gocluster.zip and UNZIP all files (i.e. with Winzip) to any directory on your hard drive.

Software copyright Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany, 2003,2004.

IMPORTANT NOTE: A mysterious bug has been reported from a couple of users. Loading the "gene directory" and "UniqID"-files was denied with no error message. This is because the dynamic link library MIDAS.DLL is not properly registered in the system's registry. Go to your Windows Start menu, choose Execute and run "regsvr32 [path to GO-Cluster]\midas.dll", where [path to GO-Cluster] is a synonym for the actual path here.


Download exemplary user files
You need to provide GO-Cluster with two adaptor files that assign the genes of your model system to appropriate GO-terms ("gene directory") and map those genes to unique identifiers for probes on the microarray ("UniqID-reference"). The structure of these files and hints how to create them is described in the help file. For our studies on the fruit-fly, we have compiled both files to incorporate all annotated Drosophila melanogaster genes (GadFly, Release 3, June 2003) and connect these to probe sets on Affymetrix Drosophila GeneChips. These files come with no warranty and you may download them (compressed ZIP-file) for your information and internal use only. Additional data files (*.got) are available in the GOT files folder.

Contact the author
The software was developed in 2003,2004 by

Boris Adryan, Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Developmental Biology, 37077 Goettingen, Germany
Phone +49 (0)551 201-1660, Fax +49 (0)551 201-1755, eMail boris.adryan@mpi-bpc.mpg.de
Current eMail-address: boris@mrc-lmb.cam.ac.uk






Legal disclaimer (please contact for English version): Dieses Programm kann von Dritten für nicht kommerzielle Zwecke unendgeltlich genutzt werden. Die Nutzung der Software erfolgt auf eigene Gefahr. Insbesondere wird für Schäden, die durch die Softwarenutzung entstehen können, z.B. Datenverluste und Folgeschäden an der Hardware, Software etc. keine Haftung übernommen. Der Nutzer stellt die MPG von möglichen Ansprüchen Dritter frei.