Prof. Dr. Manfred Eigen

- Books and Publications -

Books

• Manfred Eigen and Peter Schuster
  The Hypercycle - A Principle of Natural Self-Organization
  Springer-Verlag, Berlin, 1979
  
  
• Manfred Eigen
  Perspektiven der Wissenschaft
  Deutsche Verlagsanstalt, Stuttgart, 1988
  
  
• Manfred Eigen
  Steps Towards Life
  A Perspective on Evolution
  Oxford University Press, Oxford, 1992
  
  
• Manfred Eigen and Ruthild Winkler
  Laws of the Game
  How the Principles of Nature Govern Chance
  Princeton University Press, Princeton, 1993
  
  

Publications

since 1990

• Detection of HIV-1 RNA by nucleic acid sequence-based amplification combined with fluorescence correlation spectroscopy.
  Oehlenschläger F; Schwille P; Eigen M
  Proc. Natl. Acad. Sci. USA 93 (23). 1996. 12811-12816.
  
  
• Fluorescence correlation analysis of probe diffusion simplifies quantitative pathogen detection by PCR.
  Walter NG; Schwille P; Eigen M
  Proc. Natl. Acad. Sci. USA 93 (23). 1996. 12805-12810.
  
  
• Prionics or the kinetic basis of prion diseases.
  Eigen, M
  Biophys. Chem. (1996), 63(1), A1-A18
  
  
• Growth kinetics of a bacteriophage in continuous culture.
  Schwienhorst A; Lindemann BF; Eigen M
  Biotechnology and Bioengineering 50 (2). 1996. 217-221.
  
  
• On the nature of virus quasi-species
  Eigen M
  Trends in Microbiology, (JUN 1996) Vol. 4, No. 6, 216-218.
  
  
• Generation of biological information
  Eigen M
  Progress in Biophysics & Molecular Biology, (1996) Vol. 65, Su [1], PL3-PL3.
  # Conference
  
  
• Multichannel PCR and serial transfer machine as a future tool in evolutionary biotechnology
  Schober, A.; Walter, N. G.; Tangen, U.; Strunk, G.; Ederhof, T.; Dapprich, J.; Eigen, M.
  BioTechniques (1995), 18(4), 652-61
  
  
• Confocal scanning of single molecules
  Dapprich, J.; Mets, U.; Simm, W.; Eigen, M. ; Rigler, R.
  Exp. Tech. Phys. (Lemgo, Ger.) (1995), 41(2), 259-264
  
  
• Quasi-species: the concept and the word
  Domingo, E; Holland, J; Biebricher, C; Eigen, M
  Mol. Basis Virus Evol. (1995), 181-91. Editor(s): Gibbs, AJ.; Calisher, CH.; Garcia-Arenal, F. Cambridge University Press, Cambridge, UK.
  
  
• Selection and the origin of information.
  Eigen M
  Sporns, O. and G. Tononi (Ed.). International Review of Neurobiology, Vol. 37. Selectionism and the brain. xv+386p. Academic Press, Inc.: San Diego, California, USA; London, England, UK. 1994. 35-52.
  
  
• Foreword Mikhail V. VolkensteinÕs ÓPhysical Approaches to Biological EvolutionÒ
  Eigen M
  Springer-Verlag, Berlin-Heidelberg (1994)
  
  
• Gesetz und Zufall
  Eigen M, Winkler-Oswatitsch R
  in: Kindlers Enzyklopädie: DER MENSCH, Kindler-Verlag
  
  
• Sorting single molecules: Application to diagnostics and evolutionary biotechnology.
  Eigen M ; Rigler R
  Proc. Natl. Acad. Sci. USA 91 (13). 1994. 5740-5747.
  
  
• Phasensprünge
  Eigen M
  in: Die Würfelspiele Gottes, Hrsg. Guido Kurth, Wilhelm Heyne Verlag, München 1994, S. 201-230
  
  
• Von der Entropie zur Information - die physikalische Chemie der belebten Materie
  Eigen M
  Ber. Bunsenges. Phys. Chem.- International Journal of Physical Chemistry, (NOV 1994) Vol. 98, No. 11, 1351-1364.
  
  
• How to generate genetic information
  Eigen M
  Ber. Bunsenges. Phys. Chem.- International Journal of Physical Chemistry, (SEP 1994) Vol. 98, No. 9, 1113.
  
  
• Selection and the origin of information
  Eigen M
  International Review of Neurobiology, (1994) Vol. 37, 35-50.
  
  
• On the origin of biological information.
  Eigen M
  Biophysical Chemistry 50 (1-2). 1994. 1.
  
  
• Optimization by hierarchical mutant production.
  Schober A; Thuerk M; Eigen M
  Biological Cybernetics 69 (5-6). 1993. 493-501.
  
  
• Biological information.
  Eigen, M
  Fiz. Sz. (1993), 43(12), 481-6
  # (Hungarian)
  
  
• What will Endure of 20th Century Biology?
  Eigen M
  in: Man and Technology in the Future, ed. Engström A, The Royal Swedish Academy of Engineering, Sciences, IVA, 1993, pp. 117-135
  
  
• Was bleibt von der Biologie des 20. Jahrhunderts?
  Eigen M
  in: Entscheidung für Europa Bewußtsein und Realität. Europäisches Forum Alpbach 1992. Hrsg. Pfusterschmid-Hardtenstein H, Ibera Verlag, Wien (1993), S. 45-63
  
  
• Virus strains as models of molecular evolution. (The fifth Paul Ehrlich Lecture)
  Eigen M
  Med. Res. Rev. 13 (4). 1993. 385-398.
  
  
• Template-directed and template-free RNA synthesis by Q-beta replicase.
  Biebricher CK; Eigen M; McCaskill JS
  J. Mol. Biol. 231 (2). 1993. 175-179.
  
  
• Viral quasispecies.
  Eigen M
  Sci. Am. 269 (1). 1993. 42-49.
  
  
• The origin of genetic information: Viruses as models.
  Eigen M
  Gene 135 (1-2). 1993. 37-47.
  
  
• Analysis of the envelope region of the highly divergent HIV-2A-L-T isolate extends the known range of variability within the primate immunodeficiency viruses.
  Kreutz R; Dietrich U; Kühnel H; Nieselt-Struwe K; Eigen M ; Rübsamen-Waigmann H
  AIDS Res. Hum. Retroviruses 8 (9). 1992. 1619-1629.
  
  
• Quantitative analysis of bacteriophages with an antibody-antigen reaction
  Reinecke, M.; Yin, J.; Scheper, T.; Eigen, M.
  DECHEMA Biotechnol. Conf. (1992), 5, 455-7
  
  
• Viren als Modelle der molekularen Evolution
  Eigen M
  Naturwiss. Rundschau 45 (11). 1992. 421-425.
  
  
• Virus Quasispezies oder die Büchse der Pandora
  Eigen M
  Spektrum der Wissenschaft, Dez. 1992, 42-55
  
  
• The hypercycle coupling of RNA and protein biosynthesis in the infection cycle of an RNA bacteriophage.
  Eigen M ; Biebricher CK; Gebinoga M; Gardiner WC
  Biochemistry 30 (46). 1991. 11005-11018.
  
  
• Wie alt ist der genetische Code? Die statistische Geometrie der tRNA hat eine Antwort parat.
  Eigen M, Lindemann BF, Tietze M, Winkler-Oswatitsch R, Dress A, von Haeseler A
  in: Erkennen als geistiger und molekularer Prozeß. Hrsg. Friedrich Cramer, VCH Verlagsgesellschaft mbH, Weinheim, 1991, S. 185-203
  
  
• Quantitative analysis of selection and mutation in self-replicating RNA
  Biebricher, CK.; Eigen, M.; Gardiner, WC. Jr.
  in: Biologically Inspired Physics, Ed. L. Peliti, Plenum Press, New York, pp. 317-337 (1991)
  
  
• Wir müssen wissen, wir werden wissen
  Eigen M
  in: Wissenschaft und Ethik, Hrsg. Hans Lenk, Philip Reclam, jun., Stuttgart (1991), S. 25-39
  
  
• Zwei Kulturen?
  Eigen M
  in: Grenzübertritte: Drei Vorträge zur deutschen Literatur. Göttinger Universitätsreden. Vandenhoeck & Rubprecht, Göttingen, 1991, S. 11-21
  
  
• Statistical geometry on sequence space.
  Eigen M ; Winkler-Oswatitsch R
  Doolittle, RF (Ed.). Methods in Enzymology, Vol. 183. Molecular evolution: Computer analysis of protein and nucleic acid sequenceS. Academic Press, Inc.: San Diego, California, USA; London, UK.
  
  
• A novel proviral clone of HIV-2 - biological and phylogenetic relationship to other promate immunodeficiency viruses
  Kirchhoff F; Jentsch K D; Bachmann B; Stuke A; Laloux C; Luke W; Stahlhennig C; Schneider J; Nieselt K; Eigen M; Hunsmann G
  Virology, (1990) Vol. 177, No. 1, 305-311.
  
  
• The AIDS Debate - Reply
  Eigen M
  Naturwissenschaften, (1990) Vol. 77, No. 3, 101-102.
  
  
• How old is the immunodeficiency virus.
  Eigen M ; Nieselt-Struwe K
  AIDS, 4 (Suppl. 1). 1990. S85-S94.
  # Conference
  
  
• Enzymes are optimal catalysts - a citation classic commentary on self-organization of matter and the evolution of biological macromolecules.
  Eigen M
  Physical Chemical & Earth Sciences, (1990) No. 6, 16-17.
  
  
• Enzymes are optimal catalysts - a citation classic commentary on proton-transfer, acid-base catalysis, and enzymatic hydrolysis .1. Elementary processes.
  Eigen M
  Physical Chemical & Earth Sciences, (1990) No. 6, 16-17.
  
  
• Phase jumps - The Physical basis of life
  Eigen M
  in: Between Science and Technology, Eds. A. Sarlemijn and P. Kroes, Elsevier Science Publishers B.V. (North Holland), 1990, pp. 119-153
  
  
• Enzymes are Optimal Catalysts
  Eigen M
  Current Contents 30, 16-17 (1990)
  
  

Curriculum Vitae