Publications

2008

Winter, U. & Fasshauer, D. Mechanism of SNARE assembly and disassembly.
Landes Bioscience (Book chapter, in press) website

SNAREing the basis of multicellularity: Consequences of protein family expansion during evolution
Tobias H. Kloepper; C. Nickias Kienle; Dirk Fasshauer
Molecular Biology and Evolution 2008; doi: 10.1093/molbev/msn151 SNARE Database

Nagy G, Milosevic I, Mohrman R, Wiederhold K, Walter AM, Sørensen JB.
The SNAP-25 Linker as an Adaptation Towards Fast Exocytosis.
Mol Biol Cell. 2008 Jun 25.

Burkhardt P, Hattendorf DA, Weis WI, Fasshauer D.
Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide.
EMBO J. 2008 Apr 9;27(7):923-33.

Barszczewski M, Chua JJ, Stein A, Winter U, Heintzmann R, Zilly FE, Fasshauer D, Lang T, Jahn R.
A Novel Site of Action for {alpha}-SNAP in the SNARE Conformational Cycle Controlling Membrane Fusion.
Mol Biol Cell. 2008 Mar;19(3):776-84. pdf

2007

Stein A, Radhakrishnan A, Riedel D, Fasshauer D, Jahn R.
Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids.
Nat Struct Mol Biol. 2007 Oct;14(10):904-11. pdf

Kloepper TH, Kienle CN, Fasshauer D.
An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system.
Mol Biol Cell. 2007 Sep;18(9):3463-71. pdf SNARE Database

Fasshauer, D. & Jahn, R.
Budding insights on cell polarity (News and Views),
Nat Struct Mol Biol. 2007 May;14(5):360-2.

Siddiqui TJ, Vites O, Stein A, Heintzmann R, Jahn R, Fasshauer D.
Determinants of Synaptobrevin Regulation in Membranes.
Mol Biol Cell. 2007 Jun;18(6):2037-46. pdf

Zwilling D, Cypionka A, Pohl WH, Fasshauer D, Walla PJ, Wahl MC, Jahn R.
Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies.
EMBO J. 2007 Jan 10;26(1):9-18. pdf

2006

Pobbati AV, Stein A, Fasshauer D.
N- to C-terminal SNARE complex assembly promotes rapid membrane fusion.
Science. 2006 Aug 4;313(5787):673-6. abstract fulltext

Holt M, Varoqueaux F, Wiederhold K, Takamori S, Urlaub H, Fasshauer D, Jahn R.
Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression.
J Biol Chem. 2006 Jun 23;281(25):17076-83. pdf

Sorensen JB, Wiederhold K, Muller EM, Milosevic I, Nagy G, de Groot BL, Grubmuller H, Fasshauer D. Sequential N- to C-terminal SNARE Complex assembly drives priming and fusion of secretory vesicles.
EMBO J. 2006 Mar 8;25(5):955-66. pdf

2005

Nagy G., Milosevic I., Fasshauer D., Müller EM., de Groot BL., Lang T., Wilson MC., Sørensen JB. (2005).
Alternative Splicing of SNAP-25 Regulates Secretion through Nonconservative Substitutions in the SNARE Domain.
J. Mol. Biol. 16: 5675-85. pdf

2004

Pobbati A., Razeto A., Boddener M., Becker S., Fasshauer D. (2004).
A structural basis for the inhibitory role of tomosyn in exocytosis.
J. Biol. Chem. 279: 47192-200 (selected as “JBC Paper of the week”) pdf

Fasshauer, D. and Margittai, M. (2004)
A transient N-terminal interaction of SNAP-25 and syntaxin nucleates SNARE assembly.
J. Biol. Chem. 279: 7613-21. pdf

2003

Margittai, M., Widengren, J., Schweinberger, E., Schröder, G.F., Felekyan, E., Haustein, E., König, M., Fasshauer, D., Grubmüller, H., Jahn, R., Seidel, C.A.M. (2003).
Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin-1.
PNAS 100: 15516-21. pdf

Hatsuzawa. K., Lang, T., Fasshauer, D., Bruns, D., and Jahn, R. (2003).
The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis.
J.Biol.Chem. 278: 31159-66. pdf

Reidt, U., Wahl, M.C., Fasshauer, D., Horowitz, D.S., Lührmann, R., and Ficner, R. (2003).
Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide.
J.Mol. Biol., 331: 45-56.

Margittai, M., Fasshauer, D., Jahn, R., and Langen R. (2003).
Habc Domain and SNARE Core Complex Are Connected by a Flexible Linker.
Biochemistry, 42: 4009-14. pdf

Fasshauer D. (2003).
Structural insights into the SNARE mechanism (Review).
Biochimica et Biophysical Acta - Molecular Cell Research 1641: 87-97. pdf

2002

Pabst, S., Margittai, M., Vainius, D., Langen, R., Jahn, R., and Fasshauer, D. (2002).
Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.
J. Biol. Chem. 277: 7838-7848. pdf

Antonin, W., Fasshauer, D., Becker, S., Jahn, R., and Schneider, T.R. (2002).
Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs.
Nat. Struct. Biol. 9: 107-111. pdf

Fasshauer, D., Antonin, W., Subramaniam, V., and Jahn, R. (2002).
SNARE assembly and disassembly exhibit a pronounced hysteresis.
Nat. Struct. Biol. 9: 144-151. pdf

2001

Margittai, M., Fasshauer, D., Pabst, S., Jahn, R., and Langen, R. (2001).
Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling.
J. Biol. Chem. 276: 13169-77. pdf

2000

Antonin, W, Holroyd, C, Fasshauer, D, Pabst, S, Fischer Von Mollard, G, Jahn, R. (2000).
A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function.
EMBO J. 19:6453-64. pdf

Pabst, S., Hazzard, J.W., Antonin, W., Südhof, T.C., Jahn, R., Rizo, J., Fasshauer, D. (2000).
Selective interaction of complexin with the neuronal SNARE complex: determination of the binding regions.
J. Biol. Chem. 275:19808-18. pdf

1999

Davis, A.F., Bai, J., Fasshauer, D., Wolowick, M.J., Lewis, J.L., and Chapman, E.R. (1999).
Kinetics of Synaptotagmin Respones to Ca2+ and Assembly with the Core SNARE Complex onto Membranes.
Neuron 24: 363-76.

Fasshauer, D., Antonin, W., Margittai, M., Pabst, S., and Jahn, R. (1999).
Mixed and non-cognate SNARE complexes.
J. Biol. Chem. 274: 15440-46. pdf

1998

Fasshauer, D., Sutton, R.B., Brünger, A.T. and Jahn, R. (1998).
Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs.
Proc. Natl. Acad. Sci. USA 95: 15781-86. pdf

Sutton, R.B., Fasshauer, D., Jahn, R., and Brünger, A.T. (1998).
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution.
Nature 395: 347-353. pdf

Fasshauer, D., Eliason, W.K., Brünger, A.T., and Jahn, R. (1998).
Identification of a minimal core of the synaptic SNARE-complex sufficient for reversible assembly and disassembly.
Biochemistry 37: 10345-55. pdf

1997

Fasshauer, D., Otto, H., Eliason, W. K., Jahn, R., and Brünger, A.T. (1997).
Structural changes are associated with SNARE complex formation.
J. Biol. Chem. 272, 28036-41. pdf

Fasshauer, D., Bruns, D., Shen, B., Jahn, R., and Brünger, A.T. (1997).
A structural change occurs upon binding of syntaxin to SNAP-25.
J. Biol. Chem. 272: 4582-90. pdf

1994

Nickel W, Huber LA, Kahn RA, Kipper N, Barthel A, Fasshauer D, Soling HD.
ADP ribosylation factor and a 14-kD polypeptide are associated with heparan sulfate-carrying post-trans-Golgi network secretory vesicles in rat hepatocytes.
J Cell Biol. 1994 May;125(4):721-32.

other publications

Fasshauer, D., Schütte, C. and Jahn, R. (2001).
82nd International Titisee Conference held from October 25 to 29, 2000.
Mechanisms of membrane fusion.
B.I.F. FUTURA Vol. 16, No. 1, 13-23 (Conference report) pdf

Fasshauer, D. und Jahn, R. (2000).
Mechanismen intrazellulärer Membranfusion.
Biospektrum No. 1, 2731 (review article; german)