Prof. Derek Marsh	M E M B R A N E S E S R
Collaborations Publications/Books Authored	Research interests Structure, dynamics and thermodynamics of biological membranes investigated by biophysical methods. This includes lipid-protein interactions, protein structure and assembly, and also the physical properties of phospholipid bilayer model membranes and non-lamellar lipid phases. The principal experimental method is spin-label electron spin resonance spectroscopy, but solid-state NMR spectroscopy and Fourier transform infrared spectroscopy are also used, in addition to differential scanning calorimetry, titration calorimetry and low-angle x-ray diffraction.
Group/Troe MPIbpc home	Relevant reviews (see also Publications) Heimburg, T. and Marsh, D. Thermodynamics of the interaction of proteins with lipid membranes. In: Biological Membranes. A Molecular Perspective from Computation and Experiment (Merz Jr., K.M.., and Roux, B., eds.) pp. 405-462, Birkhäuser, Boston (1996).  Marsh, D. - Spin label ESR spectroscopy and FTIR spectroscopy for structural/dynamic measurements on ion channels. Methods. Enzymol. 294, Part C, 59-92 (1999). - Dichroic ratios in polarized Fourier transform infrared for nonaxial symmetry of b-sheet structures. Biophys. J. 72, 2710-2718 (1997).  - Magnetic resonance of lipids and proteins in membranes. Curr. Opin. Colloid Interface Sci. 2, 4-14 (1997). - Lateral pressure in membranes. Biochim. Biophys. Acta 1286, 183-223 (1996). - Peptide models for membrane channels. Biochem. J. 315, 345-361 (1996). - Physical characterization of liposomes for understanding structure-function relationships in biological membranes. In: Handbook of Nonmedical Applications of Liposomes (Barenholz, Y., and Lasic, D.D., eds.) Vol. II, pp. 1-19, CRC Press, Boca Raton (1996).  - Specificity of lipid-protein interactions. In: Biomembranes. Vol. 1 (Lee, A.G., ed.) pp. 137-186, JAI Press, Greenwich, CT (1995).  - Lipid-protein interactions and heterogeneous lipid distribution in membranes. Mol. Membr. Biol. 12, 59-64 (1995).  - Spin-labelling in biological systems. In: Electron Spin Resonance. Vol. 14 (Atherton, N.M., Davies, M.J., and Gilbert, B.C., eds.) pp. 166-202. Royal Society of Chemistry, Cambridge, 1994.  Marsh, D. and Horváth, L.I. Structure dynamics and composition of the lipid-protein interface. Perspectives from spin-labelling. Biochim. Biophys. Acta 1376, 267-296 (1998). Marsh, D. and Swamy, M. J. Derivatised lipids in membranes. Physico-chemical aspects of N-biotinyl phosphatidylethanolamines, N-acyl phosphatidylethanolamines and N-acyl ethanolamines. Chem. Phys. Lipids 105, 43-69. Marsh, D., Páli, T. and Horváth, L. I. Progressive saturation and saturation transfer EPR for measuring exchange processes and proximity relations in membranes. In: Biological Magnetic Resonance, Vol. 14. Spin Labelling. The Next Millenium (Berliner, L.J., ed.), Ch. 2, pp. 23-82, Plenum Press, New York (1998).