Ulrich Zachariae

uzachar@gwdg.de

• Membrane Proteins and Membrane Transport
• Structure, Function, and Kinetics of K+ Channels
• Solenoid Proteins as link between structured and disordered proteins
• Nucleocytoplasmic Transport: Molecular basis for selectivity
• G-Protein coupled receptor dynamics
• Protein-protein binding and allosteric effects

Publications

18. S. Villinger, R. Briones, K. Giller, U. Zachariae, A. Lange, B. L. de Groot, C. Griesinger, S. Becker, and M. Zweckstetter: Functional dynamics in the voltage-dependent anion channel. PNAS doi:10.1073/pnas.1012310108 (2010)


17. C.Kappel, U. Zachariae, N. Doelker, and H. Grubmüller: An unusual hydrophobic core confers extreme flexibility to HEAT repeat proteins. Biophys. J. 99:1596-1603 (2010)


16. J. K. Forwood, A. Lange, U. Zachariae, M. Marfori, C. Preast, H. Grubmüller, M. Stewart, A. H. Corbett, and B. Kobe: Quantitative structural analysis of importin-β flexibility: Paradigm for solenoid protein structures. Structure 18:1171-1183 (2010)


15. N. Doelker, U. Zachariae, and H. Grubmüller: Impact of hydrophilic linkers and polar contacts on the aggregation of FG nucleoporin peptides. Biophys. J. 98:2653-2661 (2010)


14. A. Stary, S. J. Wacker, L. Boukharta, U. Zachariae, Y. Karimi-Nejad, J. Åqvist, G. Vriend, and B. L. de Groot: Towards a consensus model of the hERG potassium channel. ChemMedChem 5:455-467 (2010)


13. U. Zachariae, F. Giordanetto and A.G. Leach: Side chain flexibilities in the human Ether-a-go-go Related Gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. J. Med. Chem. 52: 4266-4267 (2009)
    See also: Zelda R Wasserman: Faculty of 1000 Biology, 8 Jan 2010
    http://f1000biology.com/article/id/1366966/evaluation


12. U. Zachariae, R. Schneider, P. Velisetty, A. Lange, D. Seeliger, S.J. Wacker, Y. Karimi-Nejad, G. Vriend, S. Becker, O. Pongs, M. Baldus, and B.L. de Groot: The molecular mechanism of toxin-induced conformational changes in a potassium channel: relation to C-type inactivation. Structure 16: 747-754 (2008)


11. C. Hartmann, M. Chami, U. Zachariae, B.L. de Groot, A. Engel and M.G. Grütter: Vacuolar protein sorting: two different functional states of the AAA-ATPase Vps4p. J. Mol. Biol. 377: 352-363 (2008)


10. U. Zachariae and H. Grubmüller: Importin-beta: structural and dynamic determinants of a molecular spring. Structure 16: 906-915 (2008)


9. U. Zachariae and H. Grubmüller: A Highly Strained Nuclear Conformation of the Exportin Cse1p Revealed by Molecular Dynamics Simulations. Structure 14: 1469-1478 (2006)


8. U. Zachariae, T. Klühspies, S. De, H. Engelhardt, and K. Zeth: High resolution crystal structures and molecular dynamics simulations reveal substrate binding in the porin Omp32. J. Biol. Chem. 281: 7413-7420 (2006) [PDB structures 2FGQ/2FGR]


7. M. Grigorov, P. van Bladeren, U. Zachariae, S. Kochhar, L.B. Fay, I. Corthesy, M.A. Juillerat, and M. Affolter: Bioactive compositions, natural methods of producing them and computational methods for designing natural production processes. Patent EP1799838B1, granted EPO 2010/50 (Pub. 2005)


6. U. Zachariae: Theoretische Untersuchungen zur Elektrostatik bakterieller Porine und zur Anionentranslokation im Porin Omp32. PhD thesis, Munich University of Technology (2004)


5. A. Koumanov, U Zachariae, H. Engelhardt, and A. Karshikoff: Improved 3D continuum calculations of ion flux through membrane channels. Eur. Biophys. J. 32: 689-702 (2003)


4. U. Zachariae, V. Helms, and H. Engelhardt: Multi-step mechanism of chloride translocation in a strongly anion selective porin channel. Biophys. J. 85: 954-62 (2003)


3. U. Zachariae, A. Koumanov, H. Engelhardt, and A. Karshikoff: Electrostatic properties of the anion-selective porin Omp32 from Delftia acidovorans and of the arginine cluster of bacterial porins. Protein Sci. 11: 1309-19 (2002)


2. T.A. Schüttrigkeit *, U. Zachariae *, T. von Feilitzsch, J. Wiehler, J. von Hummel, B. Steipe, and M.E. Michel-Beyerle: Picosecond time-resolved FRET in the fluorescent protein from Discosoma Red (wt-dsRed). ChemPhysChem 2: 325-8 (2001) [*equal contribution]


1. U. Zachariae and C.R.D. Lancaster: Proton uptake associated with the reduction of the primary quinone QA influences the binding site of the secondary quinone QB in Rhodopseudomonas viridis photosynthetic reaction centres. Biochim. Biophys. Acta (Bioenergetics) 1505: 280-90 (2001).