Department home Homepage Institute Disclaimer Site Map Research Projects Gallery Publications Staff Jobs PhD programs Teaching & Conferences Downloads Contact Simulation and Interpretation of Experiments     / home / Research Projects / Experiments / pH-Dependent Insulin Aggregation and the role of entropy Insulin aggregation critically depends on pH. However, the underlying energetic and structural determinants are unknown. Applying combined mass spectrometry, atomic force spectroscopy, and molecular dynamics simulations, we have obtained structural information of ... [more] Structure Ensembles from Solid State NMR Using a combination of solid-state NMR and molecular dynamics simulation, structure ensembles of intrinsically unstructured peptides are determined. Changes in structural preferences due to environment or receptor binding could be characterized this way for the GPCR ... [more] Simulation of Fluorescence Anisotropy Experiments The labeling of proteins with fluorescent dyes is a widely used technique for studying the function of proteins e.g. by fluorescence anisotropy or FRET (fluorescence resonance energy transfer) experiments. Dyes are typically attached to proteins via a flexible linker to ... [more] Theory of dynamic force spectroscopy Recent advances in atomic force microscopy, biomembrane force probe experiments, and optical tweezers allow to measure the response of single molecules to mechanical stress with high precision. Such experiments, due to limited spatial resolution, typically access only ... [more] FRET Experiments Single-molecule Förster Resonance Energy Transfer (smFRET) measurements use the non-radiative transfer of energy from a donor to an acceptor dye. By monitoring the relative fluorescence intensities from the two dyes, the energy transfer efficiency can be evaluated for ... [more] Simulation of Membrane X-ray and Neutron Scattering In collaboration with the Institute for x-ray physics at the University of Göttingen we investigate short range structure and collective dynamics of lipid bilayer membranes. As X-ray and neutron experiments usually probe only the intensity of the fourier transform of ... [more] © 2012, Max Planck Institute for Biophysical Chemistry, Göttingen