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 Aquaporin proton exclusion |
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Bert L. de Groot and
Helmut Grubmüller
Molecular dynamics simulations have identified a strong electrostatic field in aquaporin water channels, which not only strongly polarizes passing water molecules, but also substantially contributes to the barrier against protons. This electrostatic effect therefore aids proton exclusion by aquaporins, an essential prerequisite for maintining vital bioenergetic proton gradients across biological membranes.
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References
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Bert L. de Groot and Helmut Grubmüller; The dynamics and energetics of water permeation and proton exclusion in aquaporins Curr. Opin. Struct. Biol. 15: 176-183 (2005).
[pdf]
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Bert L. de Groot, Tomaso Frigato, Volkhard Helms and Helmut Grubmüller; The mechanism of proton exclusion in the aquaporin-1 water channel. J. Mol. Biol. 333: 279-293 (2003).
[pdf]
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