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 Aquaporin Efficiency and Selectivity |
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Bert L. de Groot and Helmut Grubmüller
Why are aquaporins strictly selective for water, whereas the closely related aquaglyceroporins also permeate glycerol and other small solutes? Molecular dynamics simulations revealed a remarkable correlation between hydrophobicity and permeability for aquaporins, with only water and ammonia showing efficient permeation. The constriction filter of aquaglyceroporins lacks this feature, facilitating also the permeation of glycerol and even apolar gases.
References
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J. S. Hub and B. L. de Groot. Mechanism of selectivity in aquaporins and aquaglyceroporins. Proc. Nat. Acad. Sci. 105: 1198-1203 (2008).
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J. S. Hub and B. L. de Groot. Does CO2 permeate through Aquaporin-1? Biophys. J. 91, 842-848 (2006).
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Y. Fujiyoshi, K. Mitsuoka, B. L. de Groot, A. Philippsen, H. Grubmüller, P. Agre, and A. Engel. Structure and function of water channels. Curr. Opin. Struct. Biol. 12: 509-515 (2002).
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