Publikationen der Abt. Lührmann - Max-Planck-Institut für biophysikalische Chemie, Göttingen

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	Reinhard Lührmann



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Publikationen

Publikationen der Abteilung Lührmann

1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

Die Einträge für die Jahre 2011 und 2012 sind unvollständig

Publikationen Abteilung Zelluläre Biochemie


2011

	Agafonov, D. E., J. Deckert, E. Wolf, P. Odenwälder, S. Bessonov, C. L. Will, H. Urlaub and R. Lührmann:
	Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method.
	Molecular and Cellular Biology 31, 2667-2682 (2011)

	Grote, M.:
	The molecular architecture and structure of the human Prp19/CDC5L complex and 355 U5 sn-RNP.
	Georg-August-Universität Göttingen, Göttingen (2011)

	Liu, S., H. Ghalei, R. Lührmann and M. Wahl:
	Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31.
	RNA 17, 1655-1663 (2011)

	Muetze, J., T. Ohrt and P. Schwille:
	Fluorescence correlation spectroscopy in vivo.
	Laser and Photonics Reviews 5, 52-67 (2011)

	Odenwälder, P.:
	Elucidation of the function of proteins at the second catalytic step of the pre-mRNA splicing reaction.
	Georg-August-Universität Göttingen, Göttingen (2011)

	Ohrt, T., W. Staroske, J. Muetze, K. Crell, M. Landthaler and P. Schwille:
	Fluorescence cross-correlation spectroscopy reveals mechanistic insights into the effect of 2 '-O-methyl modified siRNAs in living cells.
	Biophysical Journal 100, 2981-2990 (2011)

	Pearson, M. D. and H. F. Noller:
	The draft genome of Planococcus donghaensis MPA1U2 reveals nonsporulation pathways controlled by a conserved Spo0A regulon.
	Journal of Bacteriology 193, 6106 (2011)

	Popow, J., M. Englert, S. Weitzer, A. Schleiffer, B. Mierzwa, K. Mechtler, S. Trowitzsch, C. L. Will, R. Lührmann, D. Soell and J. Martinez:
	HSPC117 is the essential subunit of a human tRNA splicing ligase complex.
	Science 331, 760-764 (2011)

	Rozov, A.:
	Investigation of the structure and function of the spliceosomal 220K/Prp8 protein, GGNB.
	Georg-August-Universität Göttingen, Göttingen (2011)

	Will, C. L. and R. Lührmann:
	Spliceosome structure and function.
	Cold Spring Harbor Perspectives in Biology 3, a003707 (2011)

	Zhang, Z., O. Kelemen, M. A. van Santen, S. M. Yelton, A. E. Wendlandt, V. M. Sviripa, M. Bollen, M. Beullens, H. Urlaub, R. Lührmann, D. S. Watt and S. Stamm:
	Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA.
	Journal of Biological Chemistry 286, 10126-10136 (2011)

2010

	Bessonov, S., M. Anokhina, A. Krasauskas, M. M. Golas, B. Sander, C. L. Will, H. Urlaub, H. Stark and R. Luehrmann:
	Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis.
	RNA 16, 2384-2403 (2010)

	Bessonov, S.:
	Investigation of compositional and structural dynamics of the spliceosome during its activation and the first catalytic step of splicing.
	Georg-August-Universität Göttingen, Göttingen (2010)

	Dhir, A., E. Buratti, M. A. van Santen, R. Luehrmann and F. E. Baralle:
	The intronic splicing code: Multiple factors involved in ATM pseudoexon definition.
	The EMBO Journal 29, 749-760 (2010)

	Ghalei, H., H. H. Hsiao, H. Urlaub, M. C. Wahl and N. J. Watkins:
	A novel Nop5–sRNA interaction that is required for efficient archaeal box C/D sRNP formation.
	RNA 16, 2341-2348 (2010)

	Golas, M. M., B. Sander, S. Bessonov, M. Grote, E. Wolf, B. Kastner, H. Stark and R. Luehrmann:
	3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core.
	Moleular Cell 40, 927-938 (2010)

	Grote, M., E. Wolf, C. L. Will, I. Lemm, D. E. Agafonov, A. Schomburg, W. Fischle, H. Urlaub and R. Luehrmann:
	Molecular architecture of the human Prp19/CDC5L complex.
	Molecular and Cellular Biology 30, 2105-2119 (2010)

	Kuehn-Hoelsken, E., C. Lenz, A. Dickmanns, H. H. Hsiao, F. M. Richter, B. Kastner, R. Ficner and H. Urlaub:
	Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry.
	Nucleic Acids Research 38, 5581-5593 (2010)

	Sander, B., M. M. Golas, R. Luehrmann and H. Stark:
	An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy.
	Structure 18, 667-676 (2010)

	Schmidt, C.:
	Absolute and relative quantification of proteins in large protein-RNA assembliers by mass spectrometry, GGNB.
	Georg-August-Unviersität Göttingen, Göttingen (2010)

	Schmidt, C., C. Lenz, M. Grote, R. Luehrmann and H. Urlaub:
	Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring.
	Analytical Chemistry 82, 2784-2796 (2010)

	Schneider, M., C. L. Will, M. Anokhina, J. Tazi, H. Urlaub and R. Luehrmann:
	Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes.
	Molecular Cell 38, 223-235 (2010)

	Schneider, M., H. H. Hsiao, C. L. Will, R. Giet, H. Urlaub and R. Luehrmann:
	Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.
	Nature Structural and Molecular Biology 17, 216-221 (2010)

	Stegmann, C., R. Luehrmann and M. C. Wahl:
	The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein.
	PLoS ONE 5, e10013 (2010)

	Stegmann, C.:
	Investigations of the structure and function of spliceosomal enzymes.
	Georg-August-Universität Göttingen, Göttingen (2010)

	Strzelecka, M., S. Trowitzsch, G. Weber, R. Luehrmann, A. C. Oates and K. M. Neugebauer:
	Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis.
	Nature Structural and Molecular Biology 17, 403-409 (2010)

	van Santen, M.:
	Investigation of human precatalytic spliceosome assembly using small molecule inhibitors and the reconstitution of B complexes from partially purified components.
	Georg-August-Universität Göttingen, Göttingen (2010)

	Verbeeren, J., E. H. Niemelae, J. J. Turunen, C. L. Will, J. J. Ravanti, R. Luehrmann and M. J. Frilander:
	An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing.
	Molecular Cell 37, 821-833 (2010)

	Weber, G., S. Trowitzsch, B. Kastner, R. Luehrmann and M. C. Wahl:
	Functional organization of the Sm core in the crystal structure of human U1 snRNP.
	The EMBO Journal 29, 4172-4184 (2010)

	Wolf, E.:
	Elektronenmikroskopische Lokalisierung funktioneller Zentren am isolierten Spleißosom.
	Philipps-Universität Marburg, Marburg (2010)

2009

	Eloranta, M. L., T. Loevgren, D. Finke, L. Mathsson, J. Roennelid, B. Kastner, G. Alm and L. Ronnblom:
	Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells.
	Arthritis & Rheumatism 60, 2418-2427 (2009)

	Fabrizio, P., J. Dannenberg, P. Dube, B. Kastner, H. Stark, H. Urlaub and R. Luehrmann:
	The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.
	Molecular Cell 36, 593-608 (2009)

	Herold, N., C. L. Will, E. Wolf, B. Kastner, H. Urlaub and R. Luehrmann:
	Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes.
	Molecular and Cellular Biology 29, 281-301 (2009)

	Kofler, M., M. Schuemann, C. Merz, D. Kosslick, A. Schlundt, A. Tannert, M. Schaefer, R. Luehrmann, E. Krause and C. Freund:
	Proline-rich sequence recognition I: Marking GYF and WW domain assembly sites in early spliceosomal complexes.
	Molecular and Cellular Proteomics 8, 2461-2473 (2009)

	Kuhn, A. N., M. A. Van Santen, A. Schwienhorst, H. Urlaub and R. Luehrmann:
	Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation.
	RNA 15, 153-175 (2009)

	Luehrmann, R. and H. Stark:
	Structural mapping of spliceosomes by electron microscopy.
	Current Opinion in Structural Biology 19, 96-102 (2009)

	Netter, C., G. Weber, H. Benecke and M. C. Wahl:
	Functional stabilization of a RNA recognition motif by a noncanonical N-terminal expansion.
	RNA 15, 1305-1313 (2009)

	Pena, V., S. M. Jovin, P. Fabrizio, J. Orlowski, J. M. Bujnicki, R. Luehrmann and M. C. Wahl:
	Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase.
	Molecular Cell 35, 454-466 (2009)

	Schmeisser, M.:
	New computational methods for 3D structure determination of macromolecular complexes by single particle cryo-electron microscopy.
	Universität Göttingen, Göttingen (2009)

	Schneider, M.:
	Investigation on structural and functional requirements of the formation of human pre-catalytic spliceosomes.
	Universität Göttingen, Göttingen (2009)

	Stegmann, C. M., D. Seeliger, G. M. Sheldrick, B. L. de Groot and M. C. Wahl:
	The thermodynamic influence of trapped water molecules on a protein-ligand interaction.
	Angewandte Chemie - International Edition 48, 5207-5210 (2009)

	Trowitzsch, S., G. Weber, R. Luehrmann and M. C. Wahl:
	Crystal structure of the Pml1p subunit of the yeast precursor mRNA retention and splicing complex.
	Journal of Molecular Biology 385, 531-541 (2009)

	Wahl, M. C., C. L. Will and R. Luehrmann:
	The spliceosome: design principles of a dynamic RNP machine.
	Cell 136, 701-718 (2009)

	Warkocki, Z., P. Odenwaelder, J. Schmitzova, F. Platzmann, H. Stark, H. Urlaub, R. Ficner, P. Fabrizio and R. Luehrmann:
	Reconstitution of both steps of S. cerevisiae splicing with purified spliceosomal components.
	Nature Structural and Molecular Biology 16, 1237-1243 (2009)

	Wirth, M., F. Paap, W. Fischle, D. Wenzel, D. E. Agafonov, T. R. Samatov, J. R. Wisniewski and M. Jedrusik-Bode:
	HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in C. elegans germline.
	Molecular and Cellular Biology 29, 3700-3709 (2009)

	Wolf, E., B. Kastner, J. Deckert, C. Merz, H. Stark and R. Luehrmann:
	Exon, intron and splice site locations in the spliceosomal B complex.
	EMBO Journal 28, 2283-2292 (2009)

2008

	Bessonov, S., M. Anokhina, C. L. Will, H. Urlaub and R. Luehrmann:
	Isolation of an active step I spliceosome and composition of its RNP core.
	Nature 452, 846-850 (2008)

	Haecker, I., B. Sander, M. M. Golas, E. Wolf, E. Karagoez, B. Kastner, H. Stark, P. Fabrizio and R. Luehrmann:
	Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy.
	Nature Structural and Molecular Biology 15, 1206-1212 (2008)

	Haecker, I.:
	Electron microscopic localization of tagged proteins in the yeast S. cerevisiae spliceosomal U4/U6.U5 trisnRNP.
	Universität Göttingen, Göttingen (2008)

	Herold, N.:
	Proteomic and structural analyses of purified Drosophila melanogaster spliceosomal complexes and analysis of protein composition of purified Drosophila melanogaster U11/U12 di-snRNPs.
	Universität Göttingen, Göttingen (2008)

	Hossbach, M.:
	Funktionelle Analysen von Ribonukleoprotein-Partikeln in humanen Zellkulturen durch siRNA vermittelte Unterdrückung der Genexpression.
	Justus-Liebig-Universität Gießen, Gießen (2008)

	Karaduman, R., P. Dube, H. Stark, P. Fabrizio, B. Kastner and R. Luehrmann:
	Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy.
	RNA 14, 2528-2537 (2008)

	Kastner, B., N. Fischer, M. M. Golas, B. Sander, P. Dube, D. Boehringer, K. Hartmuth, J. Deckert, F. Hauer, E. Wolf, H. Uchtenhagen, H. Urlaub, F. Herzog, J. M. Peters, D. Porschke, R. Luehrmann and H. Stark:
	GraFix: sample preparation for single-particle electron cryomicroscopy.
	Nature Methods 5, 53-55 (2008)

	Kastner, B., N. Fischer, M. M. Golas, B. Sander, P. Dube, D. Boehringer, K. Hartmuth, J. Deckert, F. Hauer, E. Wolf, H. Uchtenhagen, H. Urlaub, F. Herzog, J. M. Peters, D. Porschke, R. Luehrmann and H. Stark:
	GraFix: sample preparation for single-particle electron cryomicroscopy.
	Nature Methods 5, 53-55 (2008)

	Licht, K., J. Medenbach, R. Luehrmann, C. Kambach and A. Bindereif:
	3'-cyclic phosphorylation of U6 snRNA leads to recruitment of recycling factor p110 through LSm proteins.
	RNA 14, 1532-1538 (2008)

	Luehrmann, R.: At the heart of the spliceosome. In: FEBS Journal, 275, Suppl. 1, (2008) 13

	Mathew, R., K. Hartmuth, S. Moehlmann, H. Urlaub, R. Ficner and R. Luehrmann:
	Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.
	Nature Structural & Molecular Biology 15, 435-443 (2008)

	Pena, V., A. Rozov, P. Fabrizio, R. Luehrmann and M. C. Wahl:
	Structure and function of an RNase H domain at the heart of the spliceosome.
	The EMBO Journal 27, 2929-2940 (2008)

	Pessa, H. K., C. L. Will, X. Meng, C. Schneider, N. J. Watkins, N. Peraelae, M. Nymark, J. J. Turunen, R. Luehrmann and M. J. Frilander:
	Minor spliceosome components are predominantly localized in the nucleus.
	Proceedings of the National Academy of Sciences of the United States of America 105, 8655-8660 (2008)

	Trowitzsch, S., G. Weber, R. Luehrmann and M. C. Wahl:
	An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex.
	The Journal of Biological Chemistry 283, 32317-32327 (2008)

	Turunen, J. J., C. L. Will, M. Grote, R. Luehrmann and M. J. Frilander:
	The U11-48K protein contacts the 5' splice site of U12-Type introns and the U11-59K protein.
	Molecular and Cellular Biology 28, 3548-3560 (2008)

	Urlaub, H., E. Kuehn-Hoelsken and R. Luehrmann:
	Analyzing RNA-protein crosslinking sites in unlabeled ribonucleoprotein complexes by mass spectrometry.
	In: RNA-protein interaction protocols, (Ed.) Lin, R. J., Methods in Molecular Biology 488. Humana Press, Totowa, New York (2008) 221-245

	Yu, Y., P. A. Maroney, J. A. Denker, X. H. F. Zhang, O. Dybkov, R. Luehrmann, E. Jankowsky, L. A. Chasin and T. W. Nilsen:
	Dynamic regulation of alternative splicing by silencers that modulate 5´ splice site competition.
	Cell 135, 1224-1236 (2008)

2007

	Andrei, M. A.:
	Characterization of cytoplasmic bodies involved in 5' to 3' mRNA degradation in human cells.
	Georg-August-Universität Göttingen, Göttingen (2007)

	Behzadnia, N.:
	Untersuchungen zur Zusammenlagerung und Struktur des humanen Spleißosoms.
	Universität Hamburg, Hamburg (2007)

	Behzadnia, N., M. M. Golas, K. Hartmuth, B. Sander, B. Kastner, J. Deckert, P. Dube, C. L. Will, H. Urlaub, H. Stark and R. Luehrmann:
	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.
	The EMBO Journal 26, 1737-1748 (2007)

	Doenmez, G., K. Hartmuth, B. Kastner, C. L. Will and R. Luehrmann:
	The 5′ end of U2 snRNA is in close proximity to U1 and functional sites of the Pre-mRNA in early spliceosomal complexes.
	Molecular Cell 25, 399-411 (2007)

	Fischer, N.:
	Dynamics of ribosome-ligands complexes as revealed by cryo-EM.
	Universität Witten/Herdecke, Witten (2007)

	Kuehn-Hoelsken, E., O. Dybkov, B. Sander, R. Luehrmann and H. Urlaub:
	Improved identification of enriched peptide–RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry.
	Nucleic Acids Research 35, e95 (2007)

	Liu, S., P. Li, O. Dybkov, S. Nottrott, K. Hartmuth, R. Luehrmann, T. Carlomagno and M. C. Wahl:
	Binding of the human Prp31 nop domain to a composite RNA-protein platform in U4 snRNP.
	Science 316, 115-120 (2007)

	Luettich, M.:
	Analytische Methoden zur hochauflösenden Strukturbestimmung in der Kryo-Elektronen-Mikroskopie.
	Universität Göttingen, Göttingen (2007)

	Mathew, R.:
	Investigation of the role of protein phosphorylation in pre-mRNA splicing.
	Georg-August-Universität Göttingen, Göttingen (2007)

	Merz, C.:
	Isolierung und biochemische Charakterisierung in vitro gespleißter humaner messenger-RNPs.
	Universität Gießen, Gießen (2007)

	Merz, C., H. Urlaub, C. L. Will and R. Luehrmann:
	Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.
	RNA 13, 116-128 (2007)

	Nielsen, T. K., S. Liu, R. Luehrmann and R. Ficner:
	Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2).
	Journal of Molecular Biology 369, 902-908 (2007)

	Pena, V., S. Liu, J. M. Bujnicki, R. Luehrmann and M. C. Wahl:
	Structure of a multipartite protein-protein interaction domain in splicing factor Prp8 and its link to retinitis pigmentosa.
	Molecular Cell 25, 615-624 (2007)

	Rino, J., T. Carvalho, J. Braga, J. M. Desterro, R. Luehrmann and M. Carmo-Fonseca:
	A stochastic view of spliceosome assembly and recycling in the nucleus.
	PLoS Computational Biology 3, 2019-2031 (2007)

	Schultz, A.:
	Investigating the assembly of ribonucleoprotein complexes (RNPs).
	Universität Marburg, Marburg (2007)

	Watkins, N. J., I. Lemm and R. Luehrmann:
	Involvement of nuclear import and export factors in U8 box C/D snoRNP biogenesis.
	Molecular and Cellular Biology 27, 7018-7027 (2007)

2006

	Behzadnia, N., K. Hartmuth, C. L. Will and R. Luehrmann:
	Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP.
	RNA 12, 1738-1746 (2006)

	Bowers, H. A., P. A. Maroney, M. E. Fairman, B. Kastner, R. Luehrmann, T. W. Nilsen and E. Jankowsky:
	Discriminatory RNP remodeling by the DEAD-box protein DED1.
	RNA 12, 903-912 (2006)

	Deckert, J., K. Hartmuth, D. Boehringer, N. Behzadnia, C. L. Will, B. Kastner, H. Stark, H. Urlaub and R. Luehrmann:
	Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.
	Molecular and Cellular Biology 26, 5528-5543 (2006)

	Donnert, G., J. Keller, R. Medda, M. A. Andrei, S. O. Rizzoli, R. Luehrmann, R. Jahn, C. Eggeling and S. W. Hell:
	Macromolecular-scale resolution in biological fluorescence microscopy.
	Proceedings of the National Academy of Sciences of the United States of America 103, 11440-11445 (2006)

	Dybkov, O., C. L. Will, J. Deckert, N. Behzadnia, K. Hartmuth and R. Luehrmann:
	U2 snRNA-Protein Contacts in Purified Human 17S U2 snRNPs and in Spliceosomal A and B Complexes.
	Molecular and Cellular Biology 26, 2803-2816 (2006)

	Holt, M., F. Varoqueaux, K. Wiederhold, S. Takamori, H. Urlaub, D. Fasshauer and R. Jahn:
	Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression.
	Journal of Biological Chemistry 281, 17076-17083 (2006)

	Hossbach, M., J. Gruber, M. Osborn, K. Weber and T. Tuschl:
	Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs.
	RNA Biology 3, 82-89 (2006)

	Karaduman, R.:
	Determination of the structure of spliceosomal U6 snRNP from yeast, Saccharomyces cerevisiae.
	Georg-August-Universität, Goettingen (2006)

	Karaduman, R., P. Fabrizio, K. Hartmuth, H. Urlaub and R. Luehrmann:
	RNA structure and RNA-protein interactions in purified yeast U6 snRNPs.
	Journal of Molecular Biology 356, 1248-1262 (2006)

	Lemm, I., C. Girard, A. N. Kuhn, N. J. Watkins, M. Schneider, R. Bordonne and R. Luehrmann:
	Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies.
	Molecular Biology of the Cell 17, 3221-3231 (2006)

	Liu, S., R. Rauhut, H. P. Vornlocher and R. Luehrmann:
	The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.
	RNA 12, 1418-1430 (2006)

	Loevgren, T., M. L. Eloranta, B. Kastner, M. Wahren-Herlenius, G. V. Alm and L. Roennblom: Induction of interferon-alpha by immune complexes or liposomes containing autoantigen-associated RNA. In: Annals of the Rheumatic Diseases, 65, Suppl. 2, (2006) 460

	Loevgren, T., M. L. Eloranta, B. Kastner, M. Wahren-Herlenius, G. V. Alm and L. Roennblom:
	Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen-and Sjogren´s syndrome autoantigen-associated RNA.
	Arthritis and Rheumatism 54, 1917-1927 (2006)

	Rhode, B., K. Hartmuth, E. Westhof and R. Luehrmann:
	Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes.
	EMBO Journal 25, 2475-2486 (2006)

	Sander, B., M. M. Golas, E. M. Makarov, H. Brahms, B. Kastner, R. Luehrmann and H. Stark:
	Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by Electron Cryomicroscopy.
	Molecular Cell 24, 267-278 (2006)

	Savarese, E., O. W. Chae, S. Trowitzsch, G. Weber, B. Kastner, S. Akira, H. Wagner, R. M. Schmid, S. Bauer and A. Krug:
	U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.
	Blood 107, 3229-3234 (2006)

	Schellenberg, M. J., R. A. Edwards, D. B. Ritchie, O. A. Kent, M. M. Golas, H. Stark, R. Luehrmann, J. N. M. Glover and A. M. MacMilan:
	Crystal structure of a core spliceosomal protein interface.
	Proceedings of the National Academy of Sciences of the United States of America 103, 1266-1271 (2006)

	Schultz, A., S. Nottrott, K. Hartmuth and R. Luehrmann:
	RNA structural requirements for the association of the spliceosomal hPrp31 protein with the U4 and U4atac small nuclear ribonucleoprotein.
	Journal of Biological Chemistry 281, 28278-28286 (2006)

	Schultz, A., S. Nottrott, N. J. Watkins and R. Luehrmann:
	Protein-protein and protein-RNA contacts both contribute to the 15.5K-mediated assembly of the U4/U6 snRNP and the box C/D snoRNPs.
	Molecular and Cellular Biology 26, 5146-5154 (2006)

	Spadaccini, R., U. Reidt, O. Dybkov, C. L. Will, R. Frank, G. Stier, L. Corsini, M. C. Wahl, R. Luehrmann and M. Sattler:
	Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing.
	RNA 12, 410-425 (2006)

	Stark, H. and R. Luehrmann:
	Cryo-electron microscopy of spliceosomal components.
	Annual Review of Biophysics and Biomolecular Structure 35, 435-457 (2006)

	Trippe, R., E. Guschina, M. Hossbach, H. Urlaub, R. Luehrmann and B. J. Benecke:
	Identification, cloning and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase.
	RNA 12, 1494-1504 (2006)

2005

	Andrei, M. A., D. Ingelfinger, R. Heintzmann, T. Achsel, R. Rivera-Pomar and R. Luehrmann:
	A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.
	RNA 11, 717-727 (2005)

	Benecke, H., R. Luehrmann and C. L. Will:
	The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein.
	EMBO Journal 24, 3057-3069 (2005)

	Boehringer, D., R. Thermann, A. Ostareck-Lederer, J. D. Lewis and H. Stark:
	Structure of the hepatitis C virus IRES bound to the human 80S ribosome: Remodeling of the HCV IRES.
	Structure 13, 1695-1706 (2005)

	Chen, P. Y., H. Manninga, K. Slanchev, M. C. Chien, J. J. Russo, J. Y. Ju, R. Sheridan, B. John, D. Marks, D. Gaidatzis, C. Sander, M. Zavolan and T. Tuschl:
	The developmental miRNA profiles of zebrafish as determined by small RNA cloning.
	Genes and Development 19, 1288-1293 (2005)

	Cojocaru, V., S. Nottrott, R. Klement and T. M. Jovin:
	The snRNP 15.5K protein folds its cognate K-turn RNA. A combined theoretical and biochemical study.
	RNA 11, 197-209 (2005)

	Dube, P., F. Herzog, C. Gieffers, B. Sander, D. Riedel, S. Mueller, A. Engel, J. M. Peters and H. Stark:
	Localization of the Coactivator Cdh1 and the Cullin Subunit Apc2 in a Cryo-Electron Microscopy Model of Vertebrate APC/C.
	Molecular Cell 20, 867-879 (2005)

	Golas, M. M., B. Sander, C. L. Will, R. Luehrmann and H. Stark:
	Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy.
	Molecular Cell 17, 869-883 (2005)

	Golas, M. M.:
	Structural dynamics of core components of the spliceosome: A 3D electron cryomicroscopical study of SF3b and the minor spliceosomal U11/U12 di-snRNP.
	Georg-August-Unviersität Göttingen, Göttingen (2005)

	Gruber, J., H. Manninga, T. Tuschl, M. Osborn and K. Weber:
	Specific RNAi Mediated Gene Knockdown in Zebrafish Cell Lines.
	RNA Biology 2, 101-105 (2005)

	Hernandez, G., M. Altmann, J. M. Sierra, H. Urlaub, R. Diez del Corral, P. Schwartz and R. Rivera-Pomar:
	Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila.
	Mechanisms of Development 122, 529-543 (2005)

	Hochleitner, E. O., B. Kastner, T. Froehlich, A. Schmidt, R. Luehrmann, G. Arnold and F. Lottspeich:
	Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein - Absolute quantification using isotope-coded tags and mass spectrometry.
	Journal of Biological Chemistry 280, 2536-2542 (2005)

	Kuehn-Hoelsken, E., C. Lenz, B. Sander, R. Luehrmann and H. Urlaub:
	Complete MALDI-ToF MS analysis of cross-linked peptide-RNA oligonucleotides derived from nonlabeled UV-irradiated ribonucleoprotein particles.
	RNA 11, 1915-1930 (2005)

	Laggerbauer, B., S. Liu, E. M. Makarov, H. P. Vornlocher, O. Makarova, D. Ingelfinger, T. Achsel and R. Luehrmann:
	The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.
	RNA 11, 598-608 (2005)

	Leaman, D., P. Y. Chen, J. Fak, A. Yalcin, M. Pearce, U. Unnerstall, D. S. Marks, C. Sander, T. Tuschl and U. Gaul:
	Antisense-mediated depletion reveals essential and specific functions of MicroRNAs in Drosophila development.
	Cell 121, 1097-1108 (2005)

	Lovgren, T., M. L. Eloranta, B. Kastner, G. V. Alm and L. Ronnblom: Complexes of SLE autoantibodies and U1 snRNP particles cause production of WN-alpha in immature plasmacytoid dendritic cells. In: Arthritis and Rheumatism, 52, 9 Suppl. S, (2005) S699

	Meister, G., M. Landthaler, L. Peters, P. Y. Chen, H. Urlaub, R. Luehrmann and T. Tuschl:
	Identification of novel argonaute-associated proteins.
	Current Biology 15, 2149-2155 (2005)

	Rudolph, C., U. Schillinger, A. Ortiz, C. Plank, M. M. Golas, B. Sander, H. Stark and J. Rosenecker:
	Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium.
	Molecular Therapy 12, 493-501 (2005)

	Sander, B.:
	Three-dimensional electron cryo-microscopy of the human small nuclear ribonucleoprotein complexes [U4/U6], U5, and [U4/U6.U5] based upon novel image-processing techniques.
	Georg-August-Unviersität Göttingen, Göttingen (2005)

	Strasser, A., A. Dickmanns, R. Luehrmann and R. Ficner:
	Structural basis for m(3)G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1.
	EMBO Journal 24, 2235-2243 (2005)

	Will, C. L. and R. Luehrmann:
	Splicing of a rare class of introns by the U12-dependent spliceosome.
	Biological Chemistry 386, 713-724 (2005)

	Wozniak, A. K., S. Nottrott, E. Kuehn-Hoelsken, G. Schroeder, H. Grubmueller, R. Luehrmann, C. Seidel and F. Oesterhelt:
	Detecting protein-induced folding of the U4 snRNA kink-turn by single-molecule multiparameter FRET measurements.
	RNA 11, 1545-1554 (2005)

	Zalfa, F., S. Adinolfi, I. Napoli, E. Kuehn-Hoelsken, H. Urlaub, T. Achsel, A. Pastore and C. Bagni:
	Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif.
	Journal of Biological Chemistry 280, 33403-33410 (2005)

2004

	Boehringer, D., E. M. Makarov, B. Sander, O. Makarova, B. Kastner, R. Luehrmann and H. Stark:
	Three-dimensional structure of a pre-catalytic human spliceosomal complex B.
	Nature Structural and Molecular Biology 11, 463-468 (2004)

	Bonin, I., R. Robelek, H. Benecke, H. Urlaub, A. Bacher, G. Richter and M. C. Wahl:
	Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding.
	Biochemical Journal 383, 419-428 (2004)

	Doenmez, G., K. Hartmuth and R. Luehrmann:
	Modified nucleotides at the 5 ' end of human U2 snRNA are required for spliceosomal E-complex formation.
	RNA 10, 1925-1933 (2004)

	Granneman, S., J. Vogelzangs, R. Luehrmann, W. J. van Venrooij, G. J. M. Pruijn and N. J. Watkins:
	Role of pre-rRNA base pairing and 80S complex formation in subnucleolar localization of the U3 snoRNP.
	Molecular and Cellular Biology 24, 8600-8610 (2004)

	Hartmuth, K., H. P. Vornlocher and R. Luehrmann:
	Tobramycin affinity-tag purification of spliceosomes.
	In: mRNA processing and metabolism; methods and protocols, (Ed.) Schoenberg, D. R., Methods in molecular biology 257. Humana Pr., Totowa, N.J. (2004) 47-64

	Landthaler, M., A. Yalcin and T. Tuschl:
	The human DiGeorge syndrome critical region gene 8 and its D-melanogaster homolog are required for miRNA biogenesis.
	Current Biology 14, 2162-2167 (2004)

	Makarova, O., E. M. Makarov, H. Urlaub, C. L. Will, M. Gentzel, M. Wilm and R. Luehrmann:
	A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing.
	EMBO Journal 23, 2381-2391 (2004)

	Medenbach, J., S. Schreiner, S. Liu, R. Luehrmann and A. Bindereif:
	Human U4/U6 snRNP recycling factor p110: Mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling.
	Molecular and Cellular Biology 24, 7392-7401 (2004)

	Narayanan, U., T. Achsel, R. Luehrmann and A. G. Matera:
	Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein.
	Molecular Cell 16, 223-234 (2004)

	Peng, J. H.:
	A chemically designed enzymatic cleavage site for phosphoproteome analysis.
	ChemBioChem 5, 768-770 (2004)

	Schaffert, N., M. Hossbach, R. Heintzmann, T. Achsel and R. Luehrmann:
	RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies.
	EMBO Journal 23, 3000-3009 (2004)

	Schneider, C., C. L. Will, J. Brosius, M. J. Frilander and R. Luehrmann:
	Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila.
	Proceedings of the National Academy of Sciences of the United States of America 101, 9584-9589 (2004)

	Strasser, A., A. Dickmanns, U. Schmidt, E. Penka, H. Urlaub, M. Sekine, R. Luehrmann and R. Ficner:
	Purification, crystallization and preliminary crystallographic data of the m(3)G cap-binding domain of human snRNP import factor snurportin 1.
	Acta Crystallographica Section D-Biological Crystallography 60, 1628-1631 (2004)

	Watkins, N. J., I. Lemm, D. Ingelfinger, C. Schneider, M. Hossbach, H. Urlaub and R. Luehrmann:
	Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex.
	Molecular Cell 16, 789-798 (2004)

	Will, C. L., C. Schneider, M. Hossbach, H. Urlaub, R. Rauhut, S. M. Elbashir, T. Tuschl and R. Luehrmann:
	The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
	RNA 10, 929-941 (2004)

	Yuan, B. B., R. Latek, M. Hossbach, T. Tuschl and F. Lewitter:
	siRNA Selection Server: an automated siRNA oligonucleotide prediction server.
	Nucleic Acids Research 32, W-130-W-134 (2004)

2003

	Bartels, C., H. Urlaub, R. Luehrmann and P. Fabrizio:
	Mutagenesis suggests several roles of Snu114p in pre- mRNA splicing.
	Journal of Biological Chemistry 278, 28324-28334 (2003)

	Ingelfinger, D., S. F. Gothel, M. A. Marahiel, U. Reidt, R. Ficner, R. Luehrmann and T. Achsel:
	Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH.
	Nucleic Acids Research 31, 4791-4796 (2003)

	Lagos-Quintana, M., R. Rauhut, J. Meyer, A. Borkhardt and T. Tuschl:
	New microRNAs from mouse and human.
	RNA 9, 175-179 (2003)

	Pillai, R. S., M. Grimmler, G. Meister, C. L. Will, R. Luehrmann, U. Fischer and D. Schuemperli:
	Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.
	Genes & Development 17, 2321-2333 (2003)

	Reidt, U., M. C. Wahl, D. Fasshauer, D. Horowitz, R. Luehrmann and R. Ficner:
	Crystal Structure of a Complex Between Human Spliceosomal Cyclophilin H and a U4/U6 snRNP-60K Peptide.
	Journal of Molecular Biology 331, 45-56 (2003)

	Rhode, B., K. Hartmuth, H. Urlaub and R. Luehrmann:
	Analysis of site-specific protein-RNA cross-links in isolated RNP complexes, combining affinity selection and mass spectrometry.
	RNA-A Publication of the RNA Society 9, 1542-1551 (2003)

2002

	Bartels, C., C. Klatt, R. Luehrmann and P. Fabrizio:
	The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome.
	EMBO Reports 3, 875-880 (2002)

	Dellaire, G., E. M. Makarov, J. J. M. Cowger, D. Longman, H. G. E. Sutherland, R. Luehrmann, J. Torchia and W. A. Bickmore:
	Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
	Molecular and Cellular Biology 22, 5141-5156 (2002)

	Granneman, S., G. J. M. Pruijn, W. Horstman, W. J. van Venrooij, R. Luehrmann and N. J. Watkins:
	The hU3-55K protein requires 15.5K binding to the box B/C motif as well as flanking RNA elements for its association with the U3 small nucleolar RNA in vitro.
	Journal of Biological Chemistry 277, 48490-48500 (2002)

	Hartmuth, K., H. Urlaub, H. P. Vornlocher, C. L. Will, M. Gentzel, M. Wilm and R. Luehrmann:
	Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.
	Proceedings of the National Academy of Sciences of the United States of America 99, 16719-16724 (2002)

	Huber, J., A. Dickmanns and R. Luehrmann:
	The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro.
	Journal of Cell Biology 156, 467-479 (2002)

	Ingelfinger, D., D. J. Arndt-Jovin, R. Luehrmann and T. Achsel:
	The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrn1 in distinct cytoplasmic foci.
	RNA-A Publication of the RNA Society 8, 1489-1501 (2002)

	Lagos-Quintana, M., R. Rauhut, A. Yalcin, J. Meyer, W. Lendeckel and T. Tuschl:
	Identification of tissue-specific microRNAs from mouse.
	Current Biology 12, 735-739 (2002)

	Makarov, E. M., O. Makarova, H. Urlaub, M. Gentzel, C. L. Will, M. Wilm and R. Luehrmann:
	Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.
	Science 298, 2205-2208 (2002)

	Makarova, O., E. M. Makarov, S. Liu, H. P. Vornlocher and R. Luehrmann:
	Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6 center dot U5 tri-snRNP formation and pre-mRNA splicing.
	EMBO Journal 21, 1148-1157 (2002)

	Martinez, J., A. Patkaniowska, H. Urlaub, R. Luehrmann and T. Tuschl:
	Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.
	Cell 110, 563-574 (2002)

	Mougin, A., A. Gottschalk, P. Fabrizio, R. Luehrmann and C. Branlant:
	Direct probing of RNA structure and RNA-protein interactions in purifies HeLa cells and yeast spliceosomal U4/U6.U5 tri-snRNP particles.
	Journal of Biological Chemistry 317, 631-649 (2002)

	Nottrott, S., H. Urlaub and R. Luehrmann:
	Hierarchical, clustered protein interact ions with U4/U6 snRNA: a biochemical role for U4/U6 proteins.
	EMBO Journal 21, 5527-5538 (2002)

	Schneider, C., C. L. Will, O. Makarova, E. M. Makarov and R. Luehrmann:
	Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions.
	Molecular and Cellular Biology 22, 3219-3229 (2002)

	Urlaub, H., K. Hartmuth and R. Luehrmann:
	A two-tracked approach to analyze RNA-protein crosslinking sites in native, nonlabeled small nuclear ribonucleoprotein particles.
	Methods 26, 170-181 (2002)

	Watkins, N. J., A. Dickmanns and R. Luehrmann:
	Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP.
	Molecular and Cellular Biology 22, 8342-8352 (2002)

	Will, C. L., H. Urlaub, T. Achsel, M. Gentzel, M. Wilm and R. Luehrmann:
	Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.
	EMBO Journal 21, 4978-4988 (2002)

2001

	Achsel, T., H. Stark and R. Luehrmann:
	The Sm domain is an ancient RNA binding motif with oligo[U] specificity.
	Proceedings of the National Academy of Sciences USA 98, 3685-3689 (2001)

	Brahms, H., L. Meheus, V. De Brabandere, U. Fischer and R. Luehrmann:
	Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.
	RNA 7, 1531-1542 (2001)

	Gottschalk, A., B. Kastner, R. Luehrmann and P. Fabrizio:
	The yeast U5 snRNP co-isolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p.
	RNA 7, 1554-1566 (2001)

	Gottschalk, A., G. Neubauer, R. Luehrmann and P. Fabrizio:
	A novel yeast U2 snRNP protein, Snu17p, is required for the first catalytic step of splicing and for progression of spliceosome assembly.
	Molecular and Cellular Biology 21, 3037-3046 (2001)

	Kues, T., A. Dickmanns, R. Luehrmann, R. Peters and U. Kubitscheck:
	High intranuclear mobility and dynamic clustering of the splicing factor U1 snRNP observed by single particle tracking.
	Proceedings of the National Academy of Sciences USA 98, 12021-12026 (2001)

	Makarova, O., E. M. Makarov and R. Luehrmann:
	The 65-kD and 110-kD SR-related proteins of the human [U4/U6.U5] tri-snRNP are essential for association of the tri-snRNP with pre-spliceosomes.
	EMBO Journal 10, 2553-2563 (2001)

	Meister, G., C. Eggert, D. Buehler, H. Brahms, C. Kambach and U. Fischer:
	Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.
	Current Biology 11, 1990-1994 (2001)

	Pillai, R. S., C. L. Will, R. Luehrmann, D. Schuemperli and B. Mueller:
	Purified U7 snRNPs lack the Sm proteins D 1 and D 2 but contain Lsm 10, a new 14-kDa Sm D 1-like protein.
	EMBO Journal 20, 5470-5479 (2001)

	Reidt, U.:
	Röntgenkristallstrukturanalyse des humanen spleißosomalen Cyclophilins SnuCyp-20 und seines Komplexes mit der Bindungsdomäne des U4/U6 snRNP 60 kD Proteins.
	Marburg, (2001)

	Stark, H., P. Dube, R. Luehrmann and B. Kastner:
	Arrangement of RNA and Proteins in the spliceosomal U1 snRNP.
	Nature 409, 539-542 (2001)

	Urlaub, H., V. A. Raker, S. Kostka and R. Luehrmann:
	Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.
	EMBO Journal 20, 187-196 (2001)

	Vidovic, I., S. Nottrott, K. Hartmuth, R. Luehrmann and R. Ficner:
	Crystal structure of the spliceosomal 15.5 kD protein bound to a U4 snRNA fragment.
	Molecular Cell 6, 1331-1342 (2001)

	Will, C. L. and R. Luehrmann:
	Spliceosomal U snRNP biogenesis, structure and function.
	Current Opinion in Cell Biology 13, 290-301 (2001)

	Will, C. L. and R. Luehrmann:
	RNP remodeling with DExH/D Boxes.
	Science 291, 1916-1917 (2001)

	Will, C. L., C. Schneider, A. M. MacMilan, G. Neubauer, M. Wilm, R. Luehrmann and C. C. Query:
	A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.
	EMBO Journal 20, 4536-4546 (2001)

2000

	Brahms, H., J. Raymackers, A. Union, F. de Keyser, L. Meheus and R. Luehrmann:
	The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D 1 and D 3 contain symmetrical dimethylarginines which form a major B-cell epitope for anti-Sm autoantibodies.
	Journal of Biological Chemistry 275, 17122-17129 (2000)

	Makarov, E. M., O. Makarova, T. Achsel and R. Luehrmann:
	The human homologue of the yeast splicing factor Prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions.
	Journal of Molecular Biology 298, 567-575 (2000)

	Makarova, O.:
	Studies of proteins involved in pre-mRNA-splicing.
	Leicester, (2000)

	Raker, V. A.:
	Analysis of spliceosomal snRNP core particle assembly in vitro.
	Marburg, (2000)

	Reidt, U., K. Reuter, T. Achsel, D. Ingelfinger, R. Luehrmann and R. Ficner:
	Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin.
	Journal of Biological Chemistry 275, 7439-7442 (2000)

	Rhode, B.:
	Untersuchungen zur Funktion der U snRNAs beim Spleißen unter Verwendung stellen-spezifisch modifizierter RNA-Moleküle.
	Marburg, (2000)

	Urlaub, H., K. Hartmuth, S. Kostka, G. Grelle and R. Luehrmann:
	A general approach for identification of RNA-protein crosslinking sites within native human spliceosomal snRNPs: Analysis of RNA-protein contacts in native U 1 and [U 4/U 6.U 5] snRNPs.
	Journal of Biological Chemistry 275, 41458-41468 (2000)

	Watkins, N. J., V. Segault, B. Carpentier, S. Nottrott, P. Fabrizio, A. Bachi, M. Wilm, M. Rosbash, C. Branlant and R. Luehrmann:
	A common core RNP structure shared between the small nuclear box C/D RNPs and the spliceosomal U 4 snRNP.
	Cell 103, 457-466 (2000)

1999

	Achsel, T., H. Brahms, B. Kastner, A. Bachi, M. Wilm and R. Luehrmann:
	A doughnut-shaped heteromer of human Sm-like proteins binds to the 3′end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.
	EMBO Journal 18, 5789-5802 (1999)

	Buehler, D., V. A. Raker, R. Luehrmann and U. Fischer:
	Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy.
	Human Molecular Genetics 8, 2351-2357 (1999)

	Will, C. L. and R. Luehrmann:
	Alternative Splicing.
	Wiley-VCH, New York (1999)

	Fischer, U., V. W. Pollard, R. Luehrmann, M. Teufel, M. W. Michael, G. Dreyfuss and M. H. Malim:
	Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.
	Nucleic Acids Research 27, 4128-4134 (1999)

	Gottschalk, A., G. Neubauer, J. Banroques, M. Mann, R. Luehrmann and P. Fabrizio:
	Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5]tri-snRNP.
	EMBO Journal 18, 4535-4548 (1999)

	Harms, J., A. Tocilj, I. Levin, I. Agmon, H. Stark, I. Kolln, M. van Heel, M. Cuff, F. Schluenzen, A. Bashan, F. Franceschi and A. Yonath:
	Elucidating the medium-resolution structure of ribosomal particles: an interplay between electron cryo-microscopy and x-ray crystallography.
	Structure Folding and Design 7, 931-941 (1999)

	Hartmuth, K., V. A. Raker, J. Huber, C. Branlant and R. Luehrmann:
	An unusual chemical reactivity of Sm site adenosines strongly correlates with proper assembly of core U snRNP particles.
	Journal of Molecular Biology 285, 133-147 (1999)

	Kastner, B. and R. Luehrmann:
	Purification of U small nuclear ribonucleoprotein particles.
	Humana Press, Totowa, New York (1999)

	Kambach, C., S. Walke, R. Young, J. M. Avis, E. D. l. Fortelle, V. A. Raker, R. Luehrmann, J. Li and K. Nagai:
	Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.
	Cell 96, 375-387 (1999)

	Kleene, R., B. Kastner, R. Roesser and H. F. Kern:
	Complex formation among rat pancreatic secretory proteins under mild alkaline pH conditions.
	Digestion 60, 305-313 (1999)

	Kraemer, A., P. Grueter, K. Groening and B. Kastner:
	Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP.
	Journal of Cell Biology 145, 1355-1368 (1999)

	Nottrott, S., K. Hartmuth, P. Fabrizio, H. Urlaub, I. Vidovic, R. Ficner and R. Luehrmann:
	Functional interaction of a novel 15.5kD [U4/U6.U5]tri-snRNP protein with the 5′-stem-loop of U4 snRNA.
	EMBO Journal 18, 6119-6133 (1999)

	Paraskeva, E., E. Izaurralde, F. R. Bischoff, J. Huber, U. Kutay, E. Hartmann, R. Luehrmann and D. Görlich:
	CRM1-mediated Recycling of Snurportin 1 to the Cytoplasm.
	Journal of Cell Biology 145, 255-264 (1999)

	Raker, V. A., K. Hartmuth, B. Kastner and R. Luehrmann:
	Spliceosomal U snRNP core assembly: Sm proteins assemble onto an Sm site RNA nonanucleotide in a specific and thermodynamically stable manner.
	Molecular and Cellular Biology 19, 6554-6565 (1999)

	Reuter, K., S. Nottrott, P. Fabrizio, R. Luehrmann and R. Ficner:
	Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15kD protein.
	Journal of Molecular Biology 294, 515-525 (1999)

	Segault, V., C. L. Will, M. Polycarpou-Schwarz, I. W. Mattaj, C. Branlant and R. Luehrmann:
	Conserved loop I of U5 snRNA is dispensible for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts.
	Molecular and Cellular Biology 19, 2782-2790 (1999)

	Will, C. L., C. Schneider, R. Reed and R. Luehrmann:
	Identification of both shared and distinct proteins in the major and minor spliceosomes.
	Science 284, 2003-2005 (1999)

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