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Carmen Rotte

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Phone:+49 551 201-1304Fax:+49 551 201-1151

Email: crotte@​gwdg.de

Movies and Video Clips

Movies and Video Clips

Nanoscopy with Focused Light

For a long time, to apply light microscopy meant that details smaller than half the wavelength of light (200 nanometers) could not be resolved. Stimulated Emission Depletion (STED) microscopy and newer far-field optical approaches developed by Stefan Hell and his team at the Max Planck Institute for Biophysical Chemistry can provide up to tenfold better resolutions compared to conventional light microscopes, and in principle, are able to resolve molecular detail. For this ground-breaking techniques, Stefan Hell was awarded, among many other prizes, the 2011 Körber European Science Prize.


Super-sharp Images of the Brain

To explore the most intricate structures of the brain in order to decipher how it functions Stefan Hell’s team of researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen has made a significant step closer to this goal. Using the STED microscopy developed by Hell, the scientists have, for the first time, managed to record detailed live images inside the brain of a living mouse. Captured in the previously impossible resolution of less than 70 nanometers, these images have made the minute structures visible which allow nerve cells to communicate with each other. This application of STED microscopy opens up numerous new possibilities for neuroscientists to decode fundamental processes in the brain. (Science, February 3, 2012)

 



Magnetic Resonance Imaging in real time

Real-time MRI of a human heart at a spatial resolution of 1.5 mm and a temporal resolution of 33 ms.
(http://www.biomednmr.mpg.de) [CC-BY-SA-3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons.

Literature:
Shuo Zhang, Martin Uecker, Dirk Voit, Klaus-Dietmar Merboldt, and Jens Frahm, Real-time cardiac MRI at high temporal resolution: radial FLASH with nonlinear inverse reconstruction, Journal of Cardiovascular Magnetic Resonance 12:39 (2010) DOI:10.1186/1532-429X-12-39

Martin Uecker, Shuo Zhang, Dirk Voit, Alexander Karaus, Klaus-Dietmar Merboldt, and Jens Frahm, Real-time magnetic resonance imaging at a resolution of 20 ms, NMR in Biomedicine 23: 986ñ994 (2010) DOI:10.1002/nbm.1585


Real-time MRI of a human heart (2-chamber view) at 2.0 mm spatial resolution and 22 ms temporal resolution. The T1-weighted images were acquired with an RF-spoiled radial FLASH CMR sequence (TR/TE = 2.0/1.3 ms, flip angle 8°, 11 spokes) at 2.0 mm resolution, 8 mm section thickness, and 22 ms acquisition time without ECG or respiratory gating. Image reconstruction was achieved by regularized nonlinear inversion. (See: doi:10.1186/1532-429X-12-39 http://www.jcmr-online.com/content/12/1/39) 
(http://www.biomednmr.mpg.de) [CC-BY-2.0 (http://creativecommons.org/licenses/by/2.0)], via Wikimedia Commons.

Literature:
Martin Uecker, Shuo Zhang, Dirk Voit, Alexander Karaus, Klaus-Dietmar Merboldt, and Jens Frahm, Real-time magnetic resonance imaging at a resolution of 20 ms, NMR in Biomedicine 23: 986ñ994 (2010) DOI:10.1002/nbm.1585



Real-time MRI of speech production at a temporal resolution of 33 ms.
(http://www.biomednmr.mpg.de) [CC-BY-SA-3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons.

Literature:

Martin Uecker, Shuo Zhang, Dirk Voit, Alexander Karaus, Klaus-Dietmar Merboldt, and Jens Frahm, Real-time magnetic resonance imaging at a resolution of 20 ms, NMR in Biomedicine 23: 986-994 (2010) DOI:10.1002/nbm.1585


Real-time MRI of the knee (lateral)

(http://www.biomednmr.mpg.de) [CC-BY-SA-3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons.

Literature:
Martin Uecker, Shuo Zhang, Dirk Voit, Alexander Karaus, Klaus-Dietmar Merboldt, and Jens Frahm, Real-time magnetic resonance imaging at a resolution of 20 ms, NMR in Biomedicine 23: 986ñ994 (2010) DOI:10.1002/nbm.1585


 
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