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Models
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Model archeal RNAP-Spt4/5
(Martinez-Rucobo FW et al.: Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity. EMBO J 30, 1302-1310 (2011).)
574.55 kB
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Model bacterial RNAP-NusG
(Martinez-Rucobo FW et al.: Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity. EMBO J 30, 1302-1310 (2011).)
498.54 kB
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Models of closed and open pre-initiation complexes (Plaschka C, Hantsche M et al.: Transcription initiation complex structure elucidate DNA opening. Nature 533, 353-358(2016))
193.15 MB
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Pol II-TFIIB model1 (BUSTER electron density map for PDB 3KF1 available upon request)
(Kostrewa D et al.: RNA polymerase II-TFIIB structure and mechanism of transcription initiation. Nature 462, 323-330 (2009).)
632.49 kB
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Expressome model with DNA, mRNA, and tRNA
1.72 MB
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Pol II initially transcribing complex model
(Mühlbacher, W. et al. Conserved architecture of the core RNA polymerase II initiation complex. Nat. Commun. 5, 4310, doi:10.1038/ncomms5310 (2014).)
1.44 MB
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Pol II-TFIIB model2
(Kostrewa D et al.: RNA polymerase II-TFIIB structure and mechanism of transcription initiation. Nature 462, 323-330 (2009).)
627.75 kB
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Pol I-RRN3 model
(Blattner C et al.: Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth. Genes Dev 25, 2093-2105 (2009).)
705.64 kB
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Model yeast Pol II-Spt4/5 elongation complex
(Martinez-Rucobo FW et al.: Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity. EMBO J 30, 1302-1310 (2011).)
695.08 kB
Movies, animations, podcast
Data
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List of 32 transcripts under attenuation control
(Schulz D, Schwalb B, Kiesel A, Baejen C, Torkler P, Gagneur J, Soeding J, Cramer P: Transcriptome surveillance by selective termination of noncoding RNA synthesis. Cell 155 (5),1075-1087 (2013).)
347.0 B
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Annotation file of Nrd1 unterminated transcripts (NUTs)
(Schulz D, Schwalb B, Kiesel A, Baejen C, Torkler P, Gagneur J, Soeding J, Cramer P: Transcriptome surveillance by selective termination of noncoding RNA synthesis. Cell 155 (5), (2013).)
121.18 kB
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List of cITC-cMed protein crosslinks (Plaschka et al.: Architecture of the RNA polymerase II-Mediator core initiation complex. Nature (2015) doi:10.1038/nature14229)
61.25 kB
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List of cMed protein crosslinks (Plaschka et al.: Architecture of the RNA polymerase II-Mediator core initiation complex. Nature (2015) doi:10.1038/nature14229)
21.34 kB
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Turnover measurements in S. cerevisiae: mRNA levels, synthesis- and decay rates
(Sun M et al.: Comparative dynamic transcriptome analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation. Genome Res 22, 1350-1359 (2012).)
633.2 kB
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Turnover measurements in S. pombe: mRNA levels, synthesis- and decay rates
(Sun M et al.: Comparative dynamic transcriptome analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation. Genome Res 22, 1350-1359 (2012).)
561.63 kB
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HMM based genome-wide transcription unit (TU) annotation. (Schwalb, B; Michel, M; Zacher, B; Frühauf, K; Demel, C; Tresch, A; Gagneur, J; Cramer, P: TT-seq maps the human transient transcriptome. Science (6290), 1225 - 1228 (2016))
1.27 MB
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