Press Releases

<p>To trim away a protein</p>

To trim away a protein

November 16, 2017

To remove a protein from a cell, researchers can currently typically use two methods: genome editing by CRISPR/Cas, and RNA interference. They act on the level of DNA or RNA, respectively. However, their influence on protein amounts is indirect and takes time. German and UK scientists now present a new method, Trim-Away, which makes it possible to directly and quickly deplete a protein from any cell type. As Trim-Away can distinguish between different variants of a protein, it also opens up new venues for the therapy of diseases. more

<p><strong>Properly sorted – error-free chromosome segregation in egg cells requires actin</strong></p>

The maturation process of mammalian egg cells is highly error-prone. If in humans, for instance, chromosomes are not reliably segregated during egg maturation, this may lead to spontaneous abortion or chromosomal anomalies such as Down Syndrome. Scientists at the MPI for Biophysical Chemistry now show in the mouse model that the structural protein actin protects egg cells from mistakes during chromosome segregation. more

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