To remove a protein from a cell, researchers can currently typically use two methods: genome editing by CRISPR/Cas, and RNA interference. They act on the level of DNA or RNA, respectively. However, their influence on protein amounts is indirect and takes time. German and UK scientists now present a new method, Trim-Away, which makes it possible to directly and quickly deplete a protein from any cell type. As Trim-Away can distinguish between different variants of a protein, it also opens up new venues for the therapy of diseases.