Barbara Orth

position: PhD student

home town: Limburg an der Lahn, Germany

freetime favourites: all kinds of sports - ball sports, cardio workout, jogging, swimming, hiking…

I originally studied chemistry at the Philipps University of Marburg. After my BSc degree, I decided to focus on biochemistry and enjoyed internships in several life science labs in Marburg. Moving deeper into cell and tumor biology, I completed my MSc thesis with Prof. Thorsten Stiewe, focusing on the tumor suppressor protein p63, a truncated version of which functions as an oncogene in diverse cancer types. My work was aimed at identifying target genes of this p63 variant with the perspective of using them as potential targets in cancer therapy.  In 2017, I joined the Lorenz lab as a PhD student which has allowed me to combine both cell and structural biology. My current major research interest is in elucidating substrate recognition mechanisms in the HECT E3 ligase HUWE1.

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