Publikationen

N. Leneva, O. Kovtun, D. R. Morado, J. A. G. Briggs, D. J. Owen, Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly. Sci Adv eabf8598 (2020)

S. Tremel , Y. Ohashi, D. Morado, J. Bertram, O. Perisic, L. Brandt, M. von Wrisberg, Z. Chen, S. Maslen, O. Kovtun, J. Skehel , J. Rappsilber, K. Lang , S. Munro , J. A.G. Briggs, Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes. Nat Commun 121564 (2021). 

V. A. Tillu, J. Rae, Y. Gao, N. Ariotti, M. Floetenmeyer, O. Kovtun, K.-A. McMahon, R. G. Parton, B. M. Collins, Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation. Nat Commun 12, 931 (2021). 

O. Kovtun, V. K. Dickson, B. T. Kelly, D. J. Owen, J. A. G. Briggs, Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles. Sci Adv 6, eaba8381 (2020). 

V. A. Tillu, Y. W. Lim, O. Kovtun, S. Mureev, C. Ferguson, M. Bastiani, K. A. McMahon, H. P. Lo, T. E. Hall, K. Alexandrov, B. M. Collins, R. G. Parton, A variable undecad repeat domain in cavin1 regulates caveola formation and stability. EMBO reports, (2018). 

O. Kovtun, N. Leneva, Y. S. Bykov, N. Ariotti, R. D. Teasdale, M. Schaffer, B. D. Engel, D. J. Owen, J. A. G. Briggs, B. M. Collins, Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature 561, 561-564 (2018). 

V. A. Tillu, O. Kovtun, K. A. McMahon, B. M. Collins, R. G. Parton, A phosphoinositide- binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation. Molecular biology of the cell, (2015). 

O. Kovtun, V. A. Tillu, N. Ariotti, R. G. Parton, B. M. Collins, Cavin family proteins and the assembly of caveolae. Journal of Cell Science 128, 1269-1278 (2015). 

C.-I. A. Wang, T. Reeks, I. Vetter, I. Vergara, O. Kovtun, R. J. Lewis, P. F. Alewood, T. Durek, Isolation and Structural and Pharmacological Characterization of alpha-Elapitoxin- Dpp2d, an Amidated Three Finger Toxin from Black Mamba Venom. Biochemistry 53, 3758-3766 (2014). 

C. Mas, S. J. Norwood, A. Bugarcic, G. Kinna, N. Leneva, O. Kovtun, R. Ghai, L. E. O. Yanez, J. L. Davis, R. D. Teasdale, B. M. Collins, Structural Basis for Different Phosphoinositide Specificities of the PX Domains of Sorting Nexins Regulating G-protein Signaling. Journal of Biological Chemistry 289, 28554-28568 (2014). 

O. Kovtun, V. A. Tillu, W. Jung, N. Leneva, N. Ariotti, N. Chaudhary, R. A. Mandyam, C. Ferguson, G. P. Morgan, W. A. Johnston, S. J. Harrop, K. Alexandrov, R. G. Parton, B. M. Collins, Structural Insights into the Organization of the Cavin Membrane Coat Complex. Developmental Cell 31, 405-419 (2014). 

Y. Gambin, N. Ariotti, K.-A. McMahon, M. Bastiani, E. Sierecki, O. Kovtun, M. E. Polinkovsky, A. Magenau, W. Jung, S. Okano, Y. Zhou, N. Leneva, S. Mureev, W. Johnston, K. Gaus, J. F. Hancock, B. M. Collins, K. Alexandrov, R. G. Parton, Single- molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. Elife 3, (2014). 

J. Follett, S. J. Norwood, N. A. Hamilton, M. Mohan, O. Kovtun, S. Tay, Y. Zhe, S. A. Wood, G. D. Mellick, P. A. Silburn, B. M. Collins, A. Bugarcic, R. D. Teasdale, The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer. Traffic 15, 230-244 (2014). 

Z. Guo, W. Johnston, O. Kovtun, S. Mureev, C. Broecker, C. Ungermann, K. Alexandrov, Subunit Organisation of In Vitro Reconstituted HOPS and CORVET Multisubunit Membrane Tethering Complexes. Plos One 8, (2013). 

O. Kovtun, S. Mureev, W. Jung, M. H. Kubala, W. Johnston, K. Alexandrov, Leishmania cell-free protein expression system. Method55, 58-64 (2011). 

M. H. Kubala, O. Kovtun, K. Alexandrov, B. M. Collins, Structural and thermodynamic analysis of the GFP:GFP-nanobody complex. Protein science, (2010). 

O. Kovtun, S. Mureev, W. Johnston, K. Alexandrov, Towards the Construction of Expressed Proteomes Using a Leishmania tarentolae Based Cell-Free Expression System. Plos One 5, (2010). 

S. Mureev, O. Kovtun, U. T. T. Nguyen, K. Alexandrov, Species-independent translational leaders facilitate cell-free expression. Nature Biotechnology 27, 747-U798 (2009). 

A. A. Kovtun, N. E. Shirokilch, A. T. Gudkov, A. S. Spirin, The leader sequence of tobacco mosaic virus RNA devoid of Watson-Crick secondary structure possesses a cooperatively melted, compact conformation. Biochemical and Biophysical Research Communications 358, 368-372 (2007). 

A. A. Kovtun, A. G. Minchenko, A. T. Gudkov, Mutation analysis of the functional role of amino acid residues in domain IV of elongation factor G. Molecular Biology 40, 764-769 (2006). 

B. Aiu, D. O. Minchenko, I. L. Opentanova, O. Kovtun, S. V. Komisarenko, H. Esumi, O. H. Minchenko, [HIF-1alpha, HIF-2alpha and VHL mRNA expression in different cell lines during hypoxia]. Ukrains'kyi biokhimichnyi zhurnal, (2006). 

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