Abteilung Neurobiologie

Publikationen

Zeitschriftenartikel (349)

  1. 1.
    MPG.PuRe DOI
    Yavuz, H.; Kattan, I.; Hernandez, J. M.; Hofnagel, O.; Witkowska, A.; Raunser, S.; Walla, P. J.; Jahn, R.: Arrest of trans-SNARE zippering uncovers loosely and tightly docked intermediates in membrane fusion. Journal of Biological Chemistry (2018)
  2. 2.
    MPG.PuRe DOI
    Farsi, Z.; Gowrisankaran, S.; Krunic, M.; Rammner, B.; woehler, A.; Lafer, E. M.; Mim, C.; Jahn, R.; Milosevic, I.: Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity. eLife (2018)
  3. 3.
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    Preobraschenski, J.; Chere, C.; Ganzella, M.; Zander, J. F.; Richter, K.; Schenck, S.; Jahn, R.; Ahnert-Hilger, G.: Dual and direction-selective mechanisms of phosphate transport by the vesicular glutamate transporter. Cell Reports (2018)
  4. 4.
    MPG.PuRe DOI PDF
    Xu, Y.; Kuhlmann, J.; Brennich, M.; Komorowski, K.; Jahn, R.; Steinem, C.; Salditt, T.: Reconstitution of SNARE proteins into solid-supported lipid bilayer stacks and X-ray structure analysis. Biochimica et Biophysica Acta (BBA) - Biomembranes 1860 (2), S. 566 - 578 (2018)
  5. 5.
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    Bharat, V.; Siebrecht, M.; Burk, K.; Ahmed, S.; Reissner, C.; Kohansal-Nodehi, M.; Steubler, V.; Zweckstetter, M.; Ting, J. T.; Dean, C.: Capture of dense core vesicles at synapses by JNK-dependent phosphorylation of Synaptotagmin-4. Cell Reports (2017)
  6. 6.
    MPG.PuRe DOI
    Lissek, T.; Adams, M.; Adelman, J.; Ahissar, E.; Akaaboune, M.; Akil, H.; al'Absi, M.; Arain, F.; Arango-Lasprilla, J. C.; Atasoy, D. et al.; Avila, J.; Badawi, A.; Bading, H.; Baig, A. M.; Baleriola, J.; Belmonte, C.; Bertocci, I.; Betz, H.; Blakemore, C.; Blanke, O.; Boehm-Sturm, P.; Bonheoffer, T.; Bonifazi, P.; Brose, N.; Campolongo, P.; Celikel, T.; Chang, C. C.; Chang, T. Y.; Citri, A.; Cline, H. T.; Cortes, J. M.; Cullen, K.; Dean, K.; Delgado-Garcia, J. M.; Desroches, M.; Disterhoft, J. M.; Dowling, J. E.; Draguhn, A.; El-Kamisky, S. F.; El Manira, A.; Enam, S. A.; Encinas, J. M.; Erramuzpe, A.; Esteban, J. A.; Farinas, I.; Fischer, E.; Fukunaga, I.; Gabilondo, I.; Ganten, D.; Gidon, A.; Gomez-Esteban, J. C.; Greengard, P.; Grinevich, V. ..; Gruart, A.; Gueillemin, R.; Hariri, A. R.; Hassan, B.; Häusser, M.; Hayashi, Y.; Hussain, N. K.; Jabbar, A. A.; Jaber, M.; Jahn, R.; Janahi, E. M.; Kabbaj, M.; Kettenmann, H.; Kindt, M.; Knafo, S.; Köhr, G.; Komai, S.; Krugers, H.; Kuhn, B.; Ghazal, N. L.; Larkum, M. E.; London, M.; Lutz, B.; Matute, C.; Martinez-Millan, L.; Maroun, M.; Mc Gaugh, J.; Moustafa, A. A.; Nasim, A.; Nave, K. A.; Neher, E.; Nikolich, K.; Outeiro, T.; Palmer, L. M.; Penagarikano, O.; Perez-Otano, I.; Pfaff, D. W.; Poucet, B.; Rahman, A. U.; Ramos-Cabrer, P.; Rashidy-Pour, A.; Roberts, R. J.; Rodrigues, S.; Sanes, J. R.; Schaefer, A. T.; Segal, M.; Segev, I.; Shafqat, S.; Siddiqui, N. A.; Soreq, H.; Soriano-Garcia, E.; Spanagel, R.; Sprengel, R.; Stuart, G.; Südhof, T. C.; Tønnesen, J.; Trevino, M.; Uthman, B. M.; Venter, J. C.; Verkhratsky, A.; Weiss, C.; Wiesel, T. N.; Yaksi, E.; Yizhar, O.; Young, L. J.; Young, P.; Zawia, N. H.; Zugaza, J. L.; Hasan, M. T.: Building bridges through science. Neuron 96 (4), S. 730 - 735 (2017)
  7. 7.
    MPG.PuRe DOI PDF
    Koike, S.; Jahn, R.: Probing and manipulating intracellular membrane traffic by microinjection of artificial vesicles. Proceedings of the National Academy of Sciences of the United States of America (2017)
  8. 8.
    MPG.PuRe DOI PDF PDF PDF
    Lüningschrör, P.; Binotti, B.; Dombert, B.; Heimann, P.; Perez-Lara, A.; Slotta, C.; Thau-Habermann, N.; von Collenberg, C. R.; Karl, F.; Damme, M. et al.; Horowitz, A.; Maystadt, I.; Füchtbauer, A.; Füchtbauer, E. M.; Jablonka, S.; Blum, R.; Üçeyler, N.; Petri, S.; Kaltschmidt, B.; Jahn, R.; Kaltschmidt, C.; Sendtner, M.: Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nature Communications (2017)
  9. 9.
    MPG.PuRe DOI PDF PDF
    Scacioc, A.; Schmidt, C.; Hofmann, T.; Urlaub, H.; Kühnel, K.; Perez-Lara, A.: Structure based biophysical characterization of the PROPPIN Atg18 shows Atg18 oligomerization upon membrane binding. Scientific Reports (2017)
  10. 10.
    MPG.PuRe DOI PDF PDF
    Kliesch, T. T.; Dietz, J.; Turco, L.; Halder, P.; Polo, E.; Tarantola, M.; Jahn, R.; Janshoff, A.: Membrane tension increases fusion efficiency of model membranes in the presence of SNAREs. Scientific Reports (2017)
  11. 11.
    MPG.PuRe DOI PDF PDF PDF
    Witkowska, A.; Jahn, R.: Rapid SNARE-mediated fusion of liposomes and chromaffin granules with giant unilamellar vesicles. Biophysical Journal 113 (6), S. 1251 - 1259 (2017)
  12. 12.
    MPG.PuRe DOI
    Lanznaster, D.; Mack, J. M.; Coelho, V.; Ganzella, M.; Almeida, R. F.; Dal-Cim, T.; Hansel, G.; Zimmer, E. R.; Souza, D. O.; Prediger, R. D. et al.; Tasca, C. I.: Guanosine prevents anhedonic-like behavior and impairment in hippocampal glutamate transport following amyloid-β1–40 administration in mice. Molecular Neurobiology 54 (7), S. 5482 - 5496 (2017)
  13. 13.
    MPG.PuRe DOI PDF
    Kreutzberger, A.J. B.; Kiessling, V.; Liang, B.; Seelheim, P.; Jakhanwal, S.; Jahn, R.; Castle, J. D.; Tamm, L. K.: Reconstitution of calcium-mediated exocytosis of dense-core vesicles. Science Advances (2017)
  14. 14.
    MPG.PuRe DOI PDF
    de Almeida, R. F.; Ganzella, M.; Machado, D. G.; Loureiro, S. O.; Leffa, D.; Quincozes-Santos, A.; Pettenuzzo, L. F.; Duarte, M. M. M. F.; Duarte, T.; Souza, D. O.: Olfactory bulbectomy in mice triggers transient and long-lasting behavioral impairments and biochemical hippocampal disturbances. Progress in Neuro-Psychopharmacology and Biological Psychiatry 76, S. 1 - 11 (2017)
  15. 15.
    MPG.PuRe DOI
    Farsi, Z.; Jahn, R.; Woehler, A.: Proton electrochemical gradient: Driving and regulating neurotransmitter uptake. Bioessays 39 (5), 1600240 (2017)
  16. 16.
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    Dingjan, I.; Linders, P. T. A.; van den Bekerom, L.; Baranov, M. V.; Halder, P.; ter Beest, M.; van den Bogaart, G.; G: Oxidized phagosomal NOX2 complex is replenished from lysosomes. Journal of Cell Science 130 (7), S. 1285 - 1298 (2017)
  17. 17.
    MPG.PuRe DOI PDF
    Sudha, D.; Kohansalnodehi, M.; Kovuri, P.; Manda, S. S.; Neriyanuri, S.; Gopal, L.; Bhende, P.; Chidambaram, S.; Arunachalam, J. P.: Proteomic profiling of human intraschisis cavity fluid. Clinical Proteomics 14, 13 (2017)
  18. 18.
    MPG.PuRe DOI PDF
    Haase, J.; Grudzinska-Goebel, J.; Müller, H. K.; Münster-Wandowski, A.; Chow, E.; Wynne, K.; Farsi, Z.; Zander, J. F.; Ahnert-Hilger, G.: Serotonin transporter associated protein complexes are enriched in synaptic vesicle proteins and proteins involved in energy metabolism and ion homeostasis. ACS Chemical Neuroscience (2017)
  19. 19.
    MPG.PuRe DOI
    Almeida, R. F.; Comasseto, D. D.; Ramos, D. B.; Hansel, G.; Zimmer, E. R.; Loureiro, S. O.; Ganzella, M.; Souza, D. O.: Guanosine anxiolytic-like effect involves adenosinergic and glutamatergic neurotransmitter systems. Molecular Neurobiology 54 (1), S. 423 - 436 (2017)
  20. 20.
    MPG.PuRe DOI PDF
    Jakhanwal, S.; Lee, C. T.; Urlaub, H.; Jahn, R.: An activated Q-SNARE/SM protein complex as a possible intermediate in SNARE assembly. EMBO Journal 36, S. 1788 - 1802 (2017)
  21. 21.
    MPG.PuRe DOI PDF
    Wohnig, S.; Anatol, P. S. A.; Koppermann, S.; Mieskes, G.; Gisch, N.; Jahn, R.; Ducho, C.: Total synthesis of dansylated Park's nucleotide for high-throughput MraY assays. Chemistry - A European Journal 22 (49), S. 17813 - 17819 (2016)
  22. 22.
    MPG.PuRe DOI PDF
    Oelkers, M.; Witt, H.; Halder, P.; Jahn, R.; Janshoff, A.: SNARE-mediated membrane fusion trajectories derived from force-clamp experiments. Proceedings of the National Academy of Sciences of the United States of America (2016)
  23. 23.
    MPG.PuRe DOI PDF PDF
    Perez-Lara, A.; Thapa, A.; Nyenhuis, S. B.; Nyenhuis, D. A.; Halder, P.; Tietzel, M.; Tittmann, K.; Cafiso, D. S.; Jahn, R.: PtdInsP(2) and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium. eLife (2016)
  24. 24.
    MPG.PuRe DOI PDF PDF
    Wehland, J. D.; Lygina, A. S.; Kumar, P.; Guha, S.; Hubrich, B. E.; Jahn, R.; Diederichsen, U.: Role of the transmembrane domain in SNARE protein mediated membrane fusion: Peptide nucleic acid/peptide model systems. Molecular BioSystems 12 (9), S. 2770 - 2776 (2016)
  25. 25.
    MPG.PuRe DOI PDF PDF
    Shi, X.; Halder, P.; Yavuz, H.; Jahn, R.; Shuman, H. A.: Direct targeting of membrane fusion by SNARE mimicry: Convergent evolution of Legionella effectors. Proceedings of the National Academy of Sciences of the United States of America (2016)
  26. 26.
    MPG.PuRe DOI
    Ryu, J. K.; Jahn, R.; Yoon, T. Y.: Progresses in understanding N-ethylmaleimide sensitive factor (NSF) mediated disassembly of SNARE complexes. Biopolymers 105 (8), S. 518 - 531 (2016)
  27. 27.
    MPG.PuRe DOI
    Kim , D. I.; Kweon, H. J.; Park, Y.; Jang, D. J.; Suh, B. C.: Ca2+ controls gating of voltage-gated calcium channels by releasing the beta 2e subunit from the plasma membrane. Science Signaling (2016)
  28. 28.
    MPG.PuRe DOI PDF PDF
    Kohansalnodehi, M.; Chua, J. J.; Urlaub, H.; Jahn, R.; Czernik, D.: Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis. eLife (2016)
  29. 29.
    MPG.PuRe DOI PDF
    Milovanovic, D.; Platen, M.; Junius, M.; Diederichsen, U.; Schaap, I. A. T.; Honigmann, A.; Jahn, R.; van den Bogaar, G.: Calcium promotes the formation of syntaxin 1 mesoscale domains through phosphatidylinositol 4,5-bisphosphate. Journal of Biological Chemistry 291 (15), S. 7868 - 7876 (2016)
  30. 30.
    MPG.PuRe DOI
    Sadek, M.; Berndt, D.; Milovanovic, D.; Jahn, R.; Diederichsen, U.: Distance regulated vesicle fusion and docking mediated by β-peptide nucleic acid SNARE protein analogues. ChemBioChem 17 (6), S. 479 - 485 (2016)
  31. 31.
    MPG.PuRe DOI
    Ramos, D. B.; Muller, G. C.; Rocha, G. B. M.; Dellavia, G. H.; Almeida, R. F.; Pettenuzzo, L. F.; Loureiro, S. O.; Hansel, G.; Horn, A. C. M.; Souza, D. O. et al.; Ganzella, M.: Intranasal guanosine administration presents a wide therapeutic time window to reduce brain damage induced by permanent ischemia in rats. Purinergic Signalling 12 (1), S. 149 - 159 (2016)
  32. 32.
    MPG.PuRe DOI PDF
    Binotti, B.; Jahn, R.; Chua, J. J. E.: Functions of Rab proteins at presynaptic sites. Cells (2016)
  33. 33.
    MPG.PuRe DOI
    Farsi, Z.; Preobraschenski, J.; van den Bogaart, G.; Riedel, D.; Jahn, R.; Woehler, A.: Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles. Science 351 (6276), S. 981 - 984 (2016)
  34. 34.
    MPG.PuRe DOI PDF
    Park, Y.; Seo, J. B.; Fraind, A.; Perez-Lara, A.; Yavuz, H.; Han, K.; Jung, S. R.; Kattan, I.; Walla, P. J.; Choi, M. et al.; Cafiso, D. S.; Koh, D. S.; Jahn, R.: Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength. Nature Structural and Molecular Biology 22 (10), S. 815 - 823 (2015)
  35. 35.
    MPG.PuRe DOI PDF PDF PDF
    Kim, D. I.; Kang, M.; Kim, S.; Lee, J.; Park, Y.; Chang, I.; Suh, B. C.: Molecular basis of the membrane interaction of the beta 2e subunit of voltage-gated Ca2+ channels. Biophysical Journal 109 (5), S. 922 - 935 (2015)
  36. 36.
    MPG.PuRe DOI PDF
    Schwenen, L. L. G.; Hubrich, R.; Milovanovic, D.; Geil, B.; Yang, J.; Kros, A.; Jahn, R.; Steinem, C.: Resolving single membrane fusion events on planar pore-spanning membranes. Scientific Reports (2015)
  37. 37.
    MPG.PuRe DOI PDF
    Kim, D. I.; Park, Y.; Jang, D. J.; Suh, B. C.: Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca2+ channels. Journal of General Physiology 145 (6), S. 529 - 541 (2015)
  38. 38.
    MPG.PuRe DOI PDF
    Busse, R. A.; Scacioc, A.; Krick, R.; Pérez-Lara, A.; Thumm, M.; Kühnel, K.: Characterization of PROPPIN-phosphoinositide binding and role of Loop 6CD in PROPPIN-membrane binding. Biophysical Journal 108 (9), S. 2223 - 2234 (2015)
  39. 39.
    MPG.PuRe DOI PDF
    Perez-Lara, A.; Jahn, R.: Extended synaptotagmins (E-Syts): Architecture and dynamics of membrane contact sites revealed. Proceedings of the National Academy of Sciences of the United States of America (2015)
  40. 40.
    MPG.PuRe DOI PDF
    Milovanovic, D.; Jahn, R.: Organization and dynamics of SNARE proteins in the presynaptic membrane. Frontiers in Physiology 6, 89 (2015)
  41. 41.
    MPG.PuRe DOI PDF
    Ryu, J. K.; Min, D.; Rah, S. H.; Kim, S. J.; Park, Y.; Kim, H.; Hyeon, C.; Kim, H. M.; Jahn, R.; Yoon, T. Y.: Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover. Science 347 (6229), S. 1485 - 1489 (2015)
  42. 42.
    MPG.PuRe DOI PDF
    Larhammar, M.; Patra, K.; Blunder, M.; Emilsson, L.; Peuckert, C.; Arvidsson, E.; Ronnlund, D.; Preobraschenski, J.; Birgner, C.; Limbach, C. et al.; Widengren, J.; Blom, H.; Jahn, R.; Wallen-Mackenzie, A.; Kullander, K.: SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis. Biological Psychatry 77 (6), S. 526 - 536 (2015)
  43. 43.
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    Binotti, B.; Pavlos, N. J.; Riedel, D.; Wenzel, D.; Vorbrüggen, G.; Schalk, A. M.; Kühnel, K.; Boyken, J.; Erck, C.; Martens, H. et al.; Chua, J. J. E.; Jahn, R.: The GTPase Rab26 links synaptic vesicles to the autophagy pathway. eLife (2015)
  44. 44.
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    Milovanovic, D.; Honigmann, A.; Koike, S.; Göttfert, F.; Pahler, G.; Junius, M.; Müller, S.; Diederichsen, U.; Janshoff, A.; Grubmüller, H. et al.; Risselada, H. J.; Eggeling, C.; Hell, S. W.; van den Bogaart, G.; Jahn, R.: Hydrophobic mismatch sorts SNARE proteins into distinct membrane domains. Nature Communications (2015)
  45. 45.
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    Shcherbatyy, V.; Carson, J.; Yaylaoglu, M.; Jäckle, K.; Grabbe, F.; Brockmeyer, M.; Yavuz, H.; Eichele, G.: A digital atlas of ion channel expression patterns in the two-week-old rat brain. Neuroinformatics 13 (1), S. 111 - 125 (2015)
  46. 46.
    MPG.PuRe DOI PDF PDF
    Lin, C. C.; Seikowski, J.; Perez-Lara, A.; Jahn, R.; Höbartner, C.; Walla, P. J.: Control of membrane gaps by ​synaptotagmin-Ca2+ measured with a novel membrane distance ruler. Nature Communications (2014)
  47. 47.
    MPG.PuRe DOI PDF PDF PDF
    Preobraschenski, J.; Zander, J. F.; Suzuki, T.; Ahnert-Hilger, G.; Jahn, R.: Vesicular glutamate transporters use flexible anion and cation binding sites for efficient accumulation of neurotransmitter. Neuron 84 (6), S. 1287 - 1301 (2014)
  48. 48.
    MPG.PuRe DOI PDF PDF
    Demircioglu, F. E.; Burkhardt, P.; Fasshauer, D.: The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex. Proceedings of the National Academy of Sciences of the United States of America 111 (38), S. 13828 - 13833 (2014)
  49. 49.
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    Engelke, M.; Pirkuliyeva, S.; Kühn, J.; Wong, L.; Boyken, J.; Hermann, N.; Becker, S.; Griesinger, C.; Wienands, J.: Macromolecular assembly of the adaptor SLP-65 at intracellular vesicles in resting B cells. Science Signaling 7 (339), ra79 (2014)
  50. 50.
    MPG.PuRe DOI PDF PDF
    Hernandez, J. M.; Kreutzberger, A. J. B.; Kiessling, V.; Tamm, L. K.; Jahn, R.: Variable cooperativity in SNARE-mediated membrane fusion. Proceedings of the National Academy of Sciences of the United States of America 111 (33), S. 12037 - 12042 (2014)
  51. 51.
    MPG.PuRe DOI PDF
    Park, Y.; Vennekate, W.; Yavuz, H.; Preobraschenski, J.; Hernandez, J. M.; Riedel, D.; Walla, P. J.; Jahn, R.: alpha-SNAP interferes with the zippering of the SNARE protein membrane fusion machinery. Journal of Biological Chemistry 289 (23), S. 16326 - 16335 (2014)
  52. 52.
    MPG.PuRe DOI PDF
    Biesemann, C.; Groenborg, M.; Luquet, E.; Wichert, S. P.; Bernard, V.; Bungers, S. R.; Cooper, B.; Varoqueaux, F.; Li, L.; Byrne, J. A. et al.; Urlaub, H.; Jahn, O.; Brose, N.; Herzog, E.: Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. EMBO Journal 33 (2), S. 157 - 170 (2014)
  53. 53.
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    Behrens, C.; Binotti, B.; Schmidt, C.; Robinson, C. V.; Chua, J. J. E.; Kühnel, K.: Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation. PLoS One (2013)
  54. 54.
    MPG.PuRe DOI
    Juranek, J. K.; Mukherjee , K.; Siddiqui, T. J.; Kaplan, B. J.; Li , J. Y.; Ahnert-Hilger, G.; Jahn, R.; Calka, J.: Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat. Acta Histochemica 116 (6), S. 616 - 625 (2013)
  55. 55.
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    Kiessling, V.; Ahmed, S.; Domanska, M. K.; Holt, M.; Jahn, R.; Tamm, L. K.: Rapid fusion of synaptic vesicles with reconstituted target SNARE membranes. Biophysical Journal 104 (9), S. 1950 - 1958 (2013)
  56. 56.
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    Busse, R. A.; Scacioc, A.; Hernandez, J. M.; Krick, R.; Stephan , M.; Janshoff, A.; Thumm, M.; Kühnel, K.: Qualitative and quantitative characterization of protein-phosphoinositide interactions with liposome-based methods. Autophagy 9 (5), S. 1 - 8 (2013)
  57. 57.
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    Ahmed, S.; Holt, M.; Riedel, D.; Jahn, R.: Small-scale isolation of synaptic vesicles from mammalian brain. Nature Protocols (2013)
  58. 58.
    MPG.PuRe DOI PDF PDF
    Boyken, J.; Grønborg, M.; Riedel, D.; Urlaub, H.; Jahn, R.; Chua, J. J.: Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Neuron 78 (2), S. 285 - 297 (2013)
  59. 59.
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    Khuong, T. M.; Habets, R. L. P.; Kuenen, S.; Witkowska, A.; Kasprowicz, J.; Swerts, J.; Jahn, R.; van den Bogaart, G.; Verstreken, P.: Synaptic PI(3,4,5)P-3 is required for Syntaxin1A clustering and neurotransmitter release. Neuron 77 (6), S. 1097 - 1108 (2013)
  60. 60.
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    Martineau, M.; Shi, T.; Puyal, J.; Knolhoff, A. M.; Dulong, J.; Gasnier, B.; Klingauf, J.; Sweedler, J. V.; Jahn, R.; Mothet, J. P.: Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. Journal of Neuroscience 33 (8), S. 3413 - 3423 (2013)
  61. 61.
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    Chua, J. J.; Jahn, R.; Klopfenstein, D. R.: Managing intracellular transport. Worm 2 (1), 21564 (2013)
  62. 62.
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    Honigmann, A.; van den Bogaart, G.; Iraheta, E.; Risselada, H. J.; Milovanovic, D.; Müller, V.; Müller, S.; Diederichsen, U.; Fasshauer, D.; Grubmüller, H. et al.; Hell, S. W.; Eggeling, C.; Kühnel, K.; Jahn, R.: Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nature Structural and Molecular Biology 20, S. 679 - 686 (2013)
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    Thumm, M.; Busse, R. A.; Scacioc, A.; Stephan, M.; Janshoff, A.; Kühnel, K.; Krick, R.: It takes two to tango: PROPPINs use two phosphoinositide-binding sites. Autophagy (2013)
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    Jahn, R.; Fasshauer, D.: Molecular machines governing exocytosis of synaptic vesicles. Nature 490 (7419), S. 201 - 207 (2012)
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    Krick, R.; Busse, R. A.; Scacioc, A.; Stephan, M.; Janshoff, A.; Thumm, M.; Kühnel, K.: Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs. Proceedings of the National Academy of Sciences of the United States of America 109 (30), S. E2042 - E2049 (2012)
  66. 66.
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    Vennekate, W.; Schröder, S.; Lin, C. C.; van den Bogaart, G.; Grunwald, M.; Jahn, R.; Walla, P. J.: Cis- and trans-membrane interactions of synaptotagmin-1. Proceedings of the National Academy of Siences of the United States of America 109 (27), S. 11037 - 11042 (2012)
  67. 67.
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    Hernandez, J. M.; Stein, A.; Behrmann, E.; Riedel, D.; Cypionka, A.; Farsi, Z.; Walla, P. J.; Raunser, S.; Jahn, R.: Membrane fusion intermediates via directional and full assembly of the SNARE complex. Science 336 (6088), S. 1581 - 1584 (2012)
  68. 68.
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    van den Bogaart, G.; Meyenberg, K.; Diederichsen, U.; Jahn, R.: Phosphatidylinositol 4,5-bisphosphate increases the Ca2+ affinity of synaptotagmin-1 40-fold. Journal of Biological Chemistry 287 (20), S. 16447 - 16453 (2012)
  69. 69.
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    Chua, J. J. E.; Butkevich, E.; Worseck, J. M.; Kittelmann, M.; Gronborg, M.; Behrmann, E.; Stelzl, U.; Pavlos, N. J.; Lalowski, M. M.; Eimer, S. et al.; Wanker, E. E.; Klopfenstein, D. R.; Jahn, R.: Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter. Proceedings of the National Academy of Sciences of the United States of America 109 (15), S. 5862 - 5867 (2012)
  70. 70.
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    Ghosh, S. K.; Castorph, S.; Konovalov, O.; Salditt, T.; Jahn, R.; Holt, M.: Measuring Ca2+-induced structural changes in lipid monolayers: implications for synaptic vesicle exocytosis. Biophysical Journal 102 (6), S. 1394 - 1402 (2012)
  71. 71.
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    Park, Y.; Hernandez, J. M.; van den Bogaart, G.; Ahmed, S.; Holt, M.; Riedel, D.; Jahn, R.: Controlling synaptotagmin activity by electrostatic screening. Nature Structural and Molecular Biology 19 (10), S. 991 - 997 (2012)
  72. 72.
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    Lygina, A. S.; Meyenberg, K.; Jahn, R.; Diederichsen, U.: Transmembrane domain peptide/peptide nucleic acid hybrid as a model of a SNARE protein in vesicle fusion. Angewandte Chemie-International Edition 50 (37), S. 8597 - 8601 (2011)
  73. 73.
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    Sinha, R.; Ahmed, S.; Jahn, R.; Klingauf, J.: Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses. Proceedings of the National Academy of Sciences of the United States of America 108 (34), S. 14318 - 14323 (2011)
  74. 74.
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    van den Bogaart, G.; Jahn, R.: Counting the SNAREs needed for membrane fusion. Journal of Molecular Cell Biology 3 (4), S. 204 - 205 (2011)
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    Meiringer, C. T. A.; Rethmeier, R.; Auffarth, K.; Wilson, J.; Perz, A.; Barlowe, C.; Schmitt, H. D.; Ungermann, C.: The Dsl1 protein tethering complex is a resident endoplasmic reticulum complex, which interacts with five soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors (SNAREs) implications for fusion and fusion regulation. Journal of Biological Chemistry 286 (28), S. 25039 - 25046 (2011)
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    van den Bogaart, G.; Jahn, R.: Inside insight to membrane fusion. Proceedings of the National Academy of Sciences of the United States of America 108 (29), S. 11729 - 11730 (2011)
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    Castorph, S.; Henriques, S. S.; Holt, M.; Riedel, D.; Jahn, R.; Salditt, T.: Synaptic vesicles studied by dynamic light scattering. The European Physical Journal E 34 (6), 63 (2011)
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    van den Bogaart, G.; Thutupalli, S.; Risselada, H. J.; Meyenberg, K.; Holt, M.; Riedel, D.; Diederichsen, U.; Herminghaus, S.; Grubmüller, H.; Jahn, R.: Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation. Nature Structural and Molecular Biology 18 (7), S. 805 - 812 (2011)
  79. 79.
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    Pulido, I. R.; Jahn, R.; Gerke, V.: VAMP3 is associated with endothelial Weibel-Palade bodies and participates in their Ca2+-dependent exocytosis. Biochimica et Biophysica Acta-Molecular Cell Research 1813 (5), S. 1038 - 1044 (2011)
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    Grömer, T. W.; Thiel, C.; Holt, M.; Riedel, D.; Hua, Y.; Hueve, J.; Wilhelm, B. G.; Klingauf, J.: Amyloid precursor protein is trafficked and secreted via synaptic vesicles. PLoS One 6 (4), e18754 (2011)
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    Zilly, F. E.; Halemani, N.; Walrafen, D.; Spitta, L.; Schreiber, A.; Jahn, R.; Lang, T.: Ca2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactions. EMBO Journal 30 (7), S. 1209 - 1220 (2011)
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    Ahnert-Hilger, G.; Jahn, R.: CLC-3 spices up GABAergic synaptic vesicles. Nature Neuroscience 14 (4), S. 405 - 407 (2011)
  83. 83.
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    Kühnel, K.; Diezmann, D.: Crystal structure of the autochaperone region from the Shigella flexneri autotransporter IcsA. Journal of Bacteriology 193 (8), S. 2042 - 2045 (2011)
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    Pavlos, N. J.; Cheng, T. S.; Quin, A.; Ng, P. Y.; Feng, H. T.; Ang, E. S. M.; Carello, A.; Sung, C. H.; Jahn, R.; Zheng, M. H. et al.; Xu, J.: Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption. Molecular and Cellular Biology 31 (7), S. 1551 - 1564 (2011)
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    Meyenberg, K.; Lygina, A. S.; van den Bogaart, G.; Jahn, R.; Diederichsen, U.: SNARE derived peptide mimic inducing membrane fusion. Chemical Communications 47 (33), S. 9405 - 9407 (2011)
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    Pavlos, N. J.; Jahn, R.: Distinct yet overlapping roles of Rab GTPases on synaptic vesicles. Small GTPases 2 (2), S. 77 - 81 (2011)
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    van den Bogaart, G.; Meyenberg, K.; Risselada, H. J.; Amin, H.; Willig, K.; Hubrich, B. E.; Dier, M.; Hell, S. W.; Grubmüller, H.; Diederichsen, U. et al.; Jahn, R.: Membrane protein sequestering by ionic protein–lipid interactions. Nature 479 (7374), doi:10.1038/nature10545, S. 552 - 555 (2011)
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    Jahn, R.: VGLUTs—potential targets for the treatment of seizures? Neuron 68 (1), S. 6 - 8 (2010)
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    Pavlos, N. J.; Groenborg, M.; Riedel, D.; Chua, J. J. E.; Boyken, J.; Kloepper, T. H.; Urlaub, H.; Rizzoli, S. O.; Jahn, R.: Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Journal of Neuroscience 30 (40), S. 13441 - 13453 (2010)
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    Geumann, C.; Groenborg, M.; Hellwig, M.; Martens, H.; Jahn, R.: A sandwich enzyme-linked immunosorbent assay for the quantification of insoluble membrane and scaffold proteins. Analytical Biochemistry 402 (2), S. 161 - 169 (2010)
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    Geumann, U.; Schaefer, C.; Riedel, D.; Jahn, R.; Rizzoli, S. O.: Synaptic membrane proteins form stable microdomains in early endosomes. Microscopy Research and Technique 73 (6), S. 606 - 617 (2010)
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    Barysch, S. V.; Jahn, R.; Rizzoli, S. O.: A fluorescence-based in vitro assay for investigating early endosome dynamics. Nature Protocols (2010)
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    Schmitt, H. D.: Dsl1p/Zw10: common mechanisms behind tethering vesicles and microtubules. Trends in Cell Biology 20 (5), S. 257 - 268 (2010)
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    Rickman, C.; Medine, C. N.; Dun, A. R.; Moulton, D. J.; Mandula, O.; Halemani, N.; Rizzoli, S. O.; Chamberlain, L. H.; Duncan, R. R.: t-SNARE protein conformations patterned by the lipid microenvironment. The Journal of Biological Chemistry 285 (18), S. 13535 - 13541 (2010)
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    Mukherjee, K.; Sharma, M.; Jahn, R.; Wahl, M. C.; Suedhof, T. C.: Evolution of CASK into a Mg2+-sensitive kinase. Science Signaling 3 (119), ra33, S. 1 - 12 (2010)
  96. 96.
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    Hsu, C.; Morohashi, Y.; Yoshimura, S.; Manrique-Hoyos, N.; Jung, S.; Lauterbach, M.; Bakhti, M.; Grønborg, M.; Moebius, W.; Rhee, J. et al.; Barr, F. A.; Simons, M.: Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C. Journal of Cell Biology 189 (2), S. 223 - 232 (2010)
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    Castorph, S.; Riedel, D.; Arleth, L.; Sztucki, M.; Jahn, R.; Holt, M.; Salditt, T.: Structure parameters of synaptic vesicles quantified by small-angle x-ray scattering. Biophysical Journal 98 (7), S. 1200 - 1208 (2010)
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    Chua, J.; Kindler, S.; Boyken, J.; Jahn, R.: The architecture of an excitatory synapse. Journal of Cell Sience 123 (6), S. 819 - 823 (2010)
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    Halemani, N.; Bethani, I.; Rizzoli, S. O.; Lang, T.: Structure and dynamics of a two-helix SNARE complex in live cells. Traffic 11 (3), S. 394 - 404 (2010)
 
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