Publikationen

Zeitschriftenartikel (261)

1.
Zeitschriftenartikel
Cossa, G.; Roeschert, I.; Prinz, F.; Baluapuri, A.; Silveira Vidal, R.; Schülein-Völk, C.; Chang, Y. C.; Ade, C. P.; Mastrobuoni, G.; Girard, C. et al.; Wortmann, L.; Walz, S.; Lührmann, R.; Kempa, S.; Kuster, B.; Wolf, E.; Mumberg, D.; Eilers, M.: Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Molecular Cell, (in press) (2020)
2.
Zeitschriftenartikel
Lührmann, R.: Kiyoshi Nagai (1949-2019). RNA 26 (2), S. vii - viii (2020)
3.
Zeitschriftenartikel
Kastner, B.; Will, C. L.; Stark, H.; Lührmann, R.: Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 11 (11), a032417 (2019)
4.
Zeitschriftenartikel
Bryen, S. J.; Joshi, H.; Evesson, F. J.; Girard, C.; Ghaoui, R.; Waddell, L. B.; Testa, A. C.; Cummings, B.; Arbuckle, S.; Graf, N. et al.; Webster, R.; MacArthur, D. G.; Laing, N. G.; MR, D.; Lührmann, R.; Cooper, S. T.: Pathogenic abnormal splicing due to intronic deletions that induce biophysical space constraint for spliceosome assembly. American Journal of Human Genetics 105 (3), S. 573 - 587 (2019)
5.
Zeitschriftenartikel
Keiper, S. M.; Papasaikas, P.; Will, C. L.; Valcárcel, J.; Girard, C.; Lührmann, R.: Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications 10 (1), 3639 (2019)
6.
Zeitschriftenartikel
Bao, P.; Boon, K. L.; Will, C. L.; Hartmuth, K.; Lührmann, R.: Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research 46 (22), S. 12126 - 12138 (2018)
7.
Zeitschriftenartikel
Buskin, A.; Zhu, L.; Chichagova, V.; Basu, B.; Mozafarri Jovin, S.; Dolan, D.; Droop, A.; Collin, J.; Bronstein, R.; Mehrotra, S. et al.; Farkas, M.; Hilgen, G.; White, K.; Pan, K. T.; Treumann, A.; Hallam, D.; Bialas, K.; Chung, G.; Mellough, C.; Ding, Y.; Krasnogor, N.; Przyborski, S.; Zwolinski, S.; Al-Aama, J.; Alharthi, S.; Xu, Y.; Wheway, G.; Szymanska, K.; McKibbin, M.; Inglehearn, C. F.; Elliott, D. J.; Lindsay, S.; Ali, R. R.; Steel, D. H.; Armstrong, L.; Sernagor, E.; Urlaub, H.; Pierce, E.; Lührmann, R.; Grellscheid, S. N.; Johnson, C. A.; Lako, M.: Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications 9, 4234 (2018)
8.
Zeitschriftenartikel
Roithová, A.; Klimešová, K.; Pánek, J.; Will, C. L.; Lührmann, R.; Stanek, D.; Girard, C.: The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation. Nucleic Acids Research 46 (7), S. 3774 - 3790 (2018)
9.
Zeitschriftenartikel
Cretu, C.; Agrawal, A. A.; Cook, A.; Will, C. L.; Fekkes, P.; Smith, P. G.,.; Lührmann, R.; Larsen, N.; Buonamici, S.; Pena, V.: Structural basis of splicing modulation by antitumor macrolide compounds. Molecular Cell 70 (2), S. 265 - 273 (2018)
10.
Zeitschriftenartikel
Rocha de Moura, T.; Mozaffari-Jovin, S.; Szabo, C. Z. K.; Schmitzova, J.; Dybkov, O.; Cretu, C.; Kachala, M.; Svergun, D.; Urlaub, H.; Lührmann, R. et al.; Pena, V.: Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell 69 (6), S. 979 - 992 (2018)
11.
Zeitschriftenartikel
Haselbach, D.; Komarov, I.; Agafonov, D. E.; Hartmuth, K.; Graf, B.; Dybkov, O.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Structure and conformational dynamics of the human spliceosomal Bact complex. Cell 172 (3), S. 454 - 464, e1-e5 (2018)
12.
Zeitschriftenartikel
Bao, P.; Höbartner, C.; Hartmuth, K.; Lührmann, R.: Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing. RNA 23 (12), S. 1770 - 1779 (2017)
13.
Zeitschriftenartikel
Bao, P.; Will, C. L.; Urlaub, H.; Boon, K. L.; Lührmann, R.: The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development 31 (23-24), S. 2416 - 2429 (2017)
14.
Zeitschriftenartikel
Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), S. 701 - 713, e1 - e4 (2017)
15.
Zeitschriftenartikel
Said, N.; Krupp, F.; Anedchenko, E.; Santos, K. F.; Dybkov, O.; Huang, Y. H.; Lee, C. T.; Loll, B.; Behrmann, E.; Bürger, J. et al.; Mielke, T.; Loerke, J.; Urlaub, H.; Spahn, C. M. T.; Weber, G.; Wahl, M. C.: Structural basis for λN-dependent processive transcription antitermination. Nature Microbiology 2 (7), 17062 (2017)
16.
Zeitschriftenartikel
Fourmann, J. B.; Tauchert, M. J.; Ficner, R.; Fabrizio, P.; Lührmann, R.: Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2. Nucleic Acids Research 45 (7), S. 4068 - 4080 (2017)
17.
Zeitschriftenartikel
Sidarovich, A.; Will, C. L.; Anokhina, M. M.; Ceballos, J.; Sievers, S.; Agafonov, D. E.; Samatov, T.; Bao, P.; Kastner, B.; Urlaub, H. et al.; Waldmann, H.; Lührmann, R.: Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 6, e23533 (2017)
18.
Zeitschriftenartikel
Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), S. 318 - 323 (2017)
19.
Zeitschriftenartikel
Tauchert, M. J.; Fourmann, J. B.; Lührmann, R.; Ficner, R.: Structural insights into the mechanism of the DEAH-box RNA helicase Prp43. eLife 6, e21510 (2017)
20.
Zeitschriftenartikel
Pozzi, B.; Bragado, L.; Will, C. L.; Mammi, P.; Risso, G.; Urlaub, H.; Lührmann, R.; Srebrow, A.: SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 45 (11), S. 6729 - 6745 (2017)
21.
Zeitschriftenartikel
Cretu, C.; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De Laurentiis, E.; Sharma, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 64 (2), S. 307 - 319 (2016)
22.
Zeitschriftenartikel
Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), S. 1399 - 1405 (2016)
23.
Zeitschriftenartikel
Agafonov, D. E.; van Santen, M.; Kastner, B.; Dube, P.; Will, C. L.; Urlaub, H.; Lührmann, R.: ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 22 (9), S. 1329 - 1337 (2016)
24.
Zeitschriftenartikel
Sun, C.; Rigo, N.; Fabrizio, P.; Kastner, B.; Lührmann, R.: A protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA 22 (9), S. 1427 - 1440 (2016)
25.
Zeitschriftenartikel
Singh, J.; Sikand, K.; Conrad, H.; Will, C. L.; Komar, A. A.; Shukla, G. C.: U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III. Scientific Reports 6, 31393 (2016)
26.
Zeitschriftenartikel
Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Ficner, R.; Will, C. L.; Lührmann, R.: A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 7, 11997 (2016)
27.
Zeitschriftenartikel
Fourmann, J. B.; Dybkov, O.; Agafonov, D. E.; Tauchert, M. J.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 5, e15564 (2016)
28.
Zeitschriftenartikel
Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.; Urlaub, H.; Lührmann, R.; Stark, H.: Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), S. 1416 - 1420 (2016)
29.
Zeitschriftenartikel
Heininger, A. U.; Hackert, P.; Andreou, A. Z.; Boon, K. L.; Memet, I.; Prior, M.; Clancy, A.; Schmidt, B.; Urlaub, H.; Schleiff, E. et al.; Sloan, K. E.; Deckers, M.; Lührmann, R.; Enderlein, J.; Klostermeier, D.; Rehling, P.; Bohnsack, M. T.: Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology 13 (3), S. 320 - 330 (2016)
30.
Zeitschriftenartikel
Schütze, T.; Ulrich, A. K. C.; Apelt, L.; Will, C. L.; Bartlick, N.; Seeger, M.; Weber, G.; Lührmann, R.; Stelzl, U.; Wahl, M. C.: Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 22 (2), S. 265 - 277 (2016)
31.
Zeitschriftenartikel
Tauchert, M. J.; Fourmann, J. B.; Christian, H.; Lührmann, R.; Ficner, R.: Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 72 (2), S. 112 - 120 (2016)
32.
Zeitschriftenartikel
Jagtap, P. K. A.; Garg, D.; Kapp, T. G.; Will, C. L.; Demme, O.; Lührmann, R.; Kessler, H.; Sattler, M.: Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), S. 10190 - 10197 (2016)
33.
Zeitschriftenartikel
Absmeier, E.; Wollenhaupt, J.; Mozaffari-Jovin, S.; Becke, C.; Lee, C. T.; Preussner, M.; Heyd, F.; Urlaub, H.; Lührmann, R.; Santos, K. F. et al.; Wahl, M. C.: The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 29 (24), S. 2576 - 2587 (2015)
34.
Zeitschriftenartikel
Rigo, N.; Sun, C.; Fabrizio, P.; Kastner, B.; Lührmann, R.: Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 34 (24), S. 3059 - 3073 (2015)
35.
Zeitschriftenartikel
Schneider, C.; Agafonov, D. E.; Schmitzova, J.; Hartmuth, K.; Fabrizio, P.; Lührmann, R.: Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 11 (9), e1005539 (2015)
36.
Zeitschriftenartikel
Boesler, C.; Rigo, N.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Will, C. L.; Lührmann, R.: Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 21 (11), S. 1993 - 2005 (2015)
37.
Zeitschriftenartikel
Benito, E.; Urbanke, H.; Ramachandran, B.; Barth, J.; Halder, R.; Awasthi, A.; Jain, G.; Capece, J. G.; Burkhardt, S.; Navarro-Sala, M. et al.; Nagarajan, S.; Schütz, A. L.; Johnsen, S. A.; Bonn, S.; Lührmann, R.; Dean, C.; Fischer, A.: HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 125 (9), S. 3572 - 3584 (2015)
38.
Zeitschriftenartikel
Wahl, M. C.; Lührmann, R.: Snapshot: Spliceosome dynamics III. Cell 162 (3), S. 690 - 690.e1 (2015)
39.
Zeitschriftenartikel
Wahl, M. C.; Lührmann, R.: SnapShot: Spliceosome dynamics II. Cell 162 (2), S. 456 - 456.e1 (2015)
40.
Zeitschriftenartikel
Liu, S.; Mozaffari-Jovin, S.; Wollenhaupt, J.; Santos, , K. F.; Theuser, M.; Dunin-Horkawicz, S.; Fabrizio, P.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife 4, e07320 (2015)
41.
Zeitschriftenartikel
Wahl, M. C.; Lührmann, R.: SnapShot: Spliceosome dynamics I. Cell 161 (6), S. 1474 - 1474.e1 (2015)
42.
Zeitschriftenartikel
De, I.; Bessonov, S.; Hofele, R.; Dos Santos, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: The RNA helicase ​Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 22 (2), S. 138 - 144 (2015)
43.
Zeitschriftenartikel
Warkocki, Z.; Schneider, C.; Mozaffari-Jovin, S.; Schmitzova, J.; Höbartner, C.; Fabrizio, P.; Lührmann, R.: The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development 29 (1), S. 94 - 107 (2015)
44.
Zeitschriftenartikel
Pawellek, A.; McElroy, S.; Samatov, T.; Mitchell, L.; Woodland, A.; Ryder, U.; Gray, D.; Lührmann, R.; Lamond, A.: Identification of small molecule inhibitors of pre-mRNA splicing. The Journal of Biological Chemistry 289 (50), S. 34683 - 34698 (2014)
45.
Zeitschriftenartikel
Alló, M.; Agirre, E.; Bessonov, S.; Bertucci, P.; Acuña, L. G.; Buggiano, V.; Bellora, N.; Singh, B.; Petrilloa, E.; Blaustein, M. et al.; Miñana, B.; Dujardin, G.; Pozzi, B.; Pelisch, F.; Bechara, E.; Agafonov, D. E.; Srebrow, A.; Lührmann, R.; Valcárcel, J.; Eyras, E.; Kornblihtt, A. R.: Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proceedings of the National Academy of Sciences of the United States of America 111 (44), S. 15622 - 15629 (2014)
46.
Zeitschriftenartikel
Kramer, K.; Sachsenberg, T.; Beckmann, B. M.; Qamar, S.; Boon, K. L.; Hentze, M. W.; Kohlbacher, O.; Urlaub, H.: Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins. Nature Methods 11 (10), S. 1064 - 1070 (2014)
47.
Zeitschriftenartikel
Wysoczanski, P.; Schneider, C.; Xiang, S. Q.; Munari, F.; Trowitzsch, S.; Wahl, M. C.; Lührmann, R.; Becker, S.; Zweckstetter, M.: Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology 21 (10), S. 911 - 918 (2014)
48.
Zeitschriftenartikel
Möhlmann, S.; Mathew, R.; Neumann, P.; Schmitt, A.; Lührmann, R.; Ficner, R.: Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28. Acta Crystallographica D 70 (6), S. 1622 - 1630 (2014)
49.
Zeitschriftenartikel
Mozaffari-Jovin, S.; Wandersleben, T.; Santos, K. F.; Will, C. L.; Lührmann, R.; Wahl, M. C.: Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 11 (4), S. 298 - 312 (2014)
50.
Zeitschriftenartikel
Schmidt, C.; Groenborg, M.; Deckert, J.; Bessonov, S.; Conrad, T.; Lührmann, R.; Urlaub, H.: Mass spectrometry–based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count. RNA 20 (3), S. 406 - 420 (2014)
51.
Zeitschriftenartikel
Xiang, S. Q.; Gapsys, V.; Kim, H. Y.; Bessonov, S.; Hsiao, H. H.; Möhlmann, S.; Klaukien, V.; Ficner, R.; Becker, S.; Urlaub, H. et al.; Lührmann, R.; de Groot, B.; Zweckstetter, M.: Phosphorylation drives a dynamic switch in serine/arginine-rich proteins. Structure 21 (12), S. 2162 - 2174 (2013)
52.
Zeitschriftenartikel
Anokhina, M.; Bessonov, S.; Miao, Z. C.; Westhof, E.; Hartmuth, K.; Lührmann, R.: RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. EMBO Journal 32 (21), S. 2804 - 2818 (2013)
53.
Zeitschriftenartikel
Hofmann, J. C.; Tegha-Dunghu, J.; Dräger, S.; Will, C. L.; Lührmann, R.; Gruss, O. J.: The Prp19 complex directly functions in mitotic spindle assembly. PLoS One 8 (9), e74851 (2013)
54.
Zeitschriftenartikel
Mozaffari-Jovin, S.; Wandersleben, T.; Santos, K. F.; Will, C. L.; Lührmann, R.; Wahl, M. C.: Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 341 (6141), S. 80 - 84 (2013)
55.
Zeitschriftenartikel
Ohrt, T.; Odenwälder, P.; Dannenberg, J.; Prior , M.; Warkocki, Z.; Schmitzova, J.; Karaduman, R.; Gregor, I.; Enderlein, J.; Fabrizio, P. et al.; Lührmann, R.: Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system. RNA 19 (7), S. 902 - 915 (2013)
56.
Zeitschriftenartikel
Weber, G.; Cristao, V. F.; Santos, K. F.; Mozaffari-Jovin, S.; Heroven, A. C.; Holton, N.; Lührmann, R.; Beggs, J. D.; Wahl, M. C.: Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes and Development 27 (5), S. 525 - 540 (2013)
57.
Zeitschriftenartikel
Fourmann, J. B.; Schmitzova, J.; Christian, H.; Urlaub, H.; Ficner, R.; Boon, K. L.; Fabrizio, P.; Lührmann, R.: Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes and Development 27 (4), S. 413 - 428 (2013)
58.
Zeitschriftenartikel
Mozaffari-Jovin, S.; Santos, K. F.; Hsiao, H. H.; Will, C. L.; Urlaub, H.; Wahl, M. C.; Lührmann, R.: The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 26 (23), S. 2422 - 2434 (2012)
59.
Zeitschriftenartikel
Schmitzova, J.; Pena, V.: Emerging views about the molecular structure of the spliceosomal catalytic center. RNA Biology 9 (11), S. 1311 - 1318 (2012)
60.
Zeitschriftenartikel
Santos , K. F.; Mozaffari-Jovin, S.; Weber , G.; Pena, V.; Lührmann, R.; Wahl, M. C.: Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America 109 (43), S. 17418 - 17423 (2012)
61.
Zeitschriftenartikel
Patil, V.; Canzoneri, J. C.; Samatov, T. R.; Lührmann, R.; Oyelere, A. K.: Molecular architecture of Zinc chelating small molecules that inhibit spliceosome assembly at an early stage. RNA 18 (9), S. 1605 - 1611 (2012)
62.
Zeitschriftenartikel
Simoes-Barbosa, A.; Chakrabarti, K.; Pearson, M. D.; Benarroch, D.; Shuman, S.; Johnson, P. J.: Box H/ACA snoRNAs are preferred substrates for the trimethylguanosine synthase in the divergent unicellular eukaryote Trichomonas vaginalis. RNA 18 (9), S. 1656 - 1665 (2012)
63.
Zeitschriftenartikel
Girard, C.; Will, C. L.; Peng, J.; Makarov, E. M.; Kastner, B.; Lemm, I.; Urlaub, H.; Hartmuth, K.; Lührmann, R.: Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 3, 994 (2012)
64.
Zeitschriftenartikel
Wolf, E.; Kastner, B.; Lührmann, R.: Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex. RNA 18 (7), S. 1347 - 1357 (2012)
65.
Zeitschriftenartikel
Rasche, N.; Dybkov, O.; Schmitzova, J.; Akyildiz, B.; Fabrizio, P.; Lührmann, R.: Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal 31 (6), S. 1591 - 1604 (2012)
66.
Zeitschriftenartikel
Samatov, T. R.; Wolf, A.; Odenwälder, P.; Bessonov, S.; Deraeve, C.; Bon, R. S.; Waldmann, H.; Lührmann, R.: Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem 13 (5), S. 640 - 644 (2012)
67.
Zeitschriftenartikel
Hegele, A.; Kamburov, A.; Grossmann, A.; Sourlis, C.; Wowro, S.; Weimann, M.; Will, C. L.; Pena, V.; Lührmann, R.; Stelzl, U.: Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 45 (4), S. 567 - 580 (2012)
68.
Zeitschriftenartikel
Ohrt, T.; Prior, M.; Dannenberg, J.; Odenwälder, P.; Dybkov, O.; Rasche, N.; Schmitzova, J.; Gregor, I.; Fabrizio, P.; Enderlein, J. et al.; Lührmann, R.: Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA 18 (6), S. 1244 - 1256 (2012)
69.
Zeitschriftenartikel
Schmitzova, J.; Rasche, N.; Dybkov, O.; Kramer, K.; Fabrizio, P.; Urlaub, H.; Lührmann, R.; Pena, V.: Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 31 (9), S. 2222 - 2234 (2012)
70.
Zeitschriftenartikel
Liu, S.; Ghalei, H.; Lührmann, R.; Wahl, M.: Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. RNA 17 (9), S. 1655 - 1663 (2011)
71.
Zeitschriftenartikel
Agafonov, D. E.; Deckert, J.; Wolf, E.; Odenwälder, P.; Bessonov, S.; Will, C. L.; Urlaub, H.; Lührmann, R.: Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology 31 (13), S. 2667 - 2682 (2011)
72.
Zeitschriftenartikel
Zhang, Z.; Kelemen, O.; van Santen, M. A.; Yelton, S. M.; Wendlandt, A. E.; Sviripa, V. M.; Bollen, M.; Beullens, M.; Urlaub, H.; Lührmann, R. et al.; Watt, D. S.; Stamm, S.: Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. Journal of Biological Chemistry 286 (12), S. 10126 - 10136 (2011)
73.
Zeitschriftenartikel
Popow, J.; Englert, M.; Weitzer, S.; Schleiffer, A.; Mierzwa, B.; Mechtler, K.; Trowitzsch, S.; Will, C. L.; Lührmann, R.; Soell, D. et al.; Martinez, J.: HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 331 (6018), S. 760 - 764 (2011)
74.
Zeitschriftenartikel
Golas, M. M.; Sander, B.; Bessonov, S.; Grote, M.; Wolf, E.; Kastner, B.; Stark, H.; Lührmann, R.: 3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core. Molecular Cell 40 (6), S. 927 - 938 (2010)
75.
Zeitschriftenartikel
Bessonov, S.; Anokhina, M.; Krasauskas, A.; Golas, M. M.; Sander, B.; Will, C. L.; Urlaub, H.; Stark, H.; Lührmann, R.: Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 16 (12), S. 2384 - 2403 (2010)
76.
Zeitschriftenartikel
Sander, B.; Golas, M. M.; Lührmann, R.; Stark, H.: An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy. Structure 18 (6), S. 667 - 676 (2010)
77.
Zeitschriftenartikel
Grote, M.; Wolf, E.; Will, C. L.; Lemm, I.; Agafonov, D. E.; Schomburg, A.; Fischle, W.; Urlaub, H.; Lührmann, R.: Molecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology 30 (9), S. 2105 - 2119 (2010)
78.
Zeitschriftenartikel
Kühn-Hölsken, E.; Lenz, C.; Dickmanns, A.; Hsiao, H. H.; Richter, F. M.; Kastner, B.; Ficner, R.; Urlaub, H.: Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry. Nucleic Acids Research 38 (16), S. 5581 - 5593 (2010)
79.
Zeitschriftenartikel
Schneider, M.; Will, C. L.; Anokhina, M.; Tazi, J.; Urlaub, H.; Lührmann, R.: Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Molecular Cell 38 (2), S. 223 - 235 (2010)
80.
Zeitschriftenartikel
Stegmann, C.; Lührmann, R.; Wahl, M. C.: The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS ONE 5, e10013 (2010)
81.
Zeitschriftenartikel
Strzelecka, M.; Trowitzsch, S.; Weber, G.; Lührmann, R.; Oates, A. C.; Neugebauer, K. M.: Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nature Structural and Molecular Biology 17 (4), S. 403 - 409 (2010)
82.
Zeitschriftenartikel
Verbeeren, J.; Niemelae, E. H.; Turunen, J. J.; Will, C. L.; Ravanti, J. J.; Lührmann, R.; Frilander, M. J.: An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Molecular Cell 37 (6), S. 821 - 833 (2010)
83.
Zeitschriftenartikel
Schneider, M.; Hsiao, H. H.; Will, C. L.; Giet, R.; Urlaub, H.; Lührmann, R.: Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural and Molecular Biology 17 (2), S. 216 - 222 (2010)
84.
Zeitschriftenartikel
Dhir, A.; Buratti, E.; van Santen, M. A.; Lührmann, R.; Baralle, F. E.: The intronic splicing code: Multiple factors involved in ATM pseudoexon definition. The EMBO Journal 29, S. 749 - 760 (2010)
85.
Zeitschriftenartikel
Schmidt, C.; Lenz, C.; Grote, M.; Lührmann, R.; Urlaub, H.: Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring. Analytical Chemistry 82 (7), S. 2784 - 2796 (2010)
86.
Zeitschriftenartikel
Weber, G.; Trowitzsch, S.; Kastner, B.; Lührmann, R.; Wahl, M. C.: Functional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO Journal 29, S. 4172 - 4184 (2010)
87.
Zeitschriftenartikel
Warkocki, Z.; Odenwälder, P.; Schmitzova, J.; Platzmann, F.; Stark, H.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: Reconstitution of both steps of S. cerevisiae splicing with purified spliceosomal components. Nature Structural and Molecular Biology 16 (12), S. 1237 - 1243 (2009)
88.
Zeitschriftenartikel
Said, N.; Rieder, R.; Hurwitz, R.; Deckert, J.; Urlaub, H.; Vogel, J.: In vivo expression and purification of aptamer-tagged small RNA regulators. Nucleic Acids Research 37 (20), e133 (2009)
89.
Zeitschriftenartikel
Wirth, M.; Paap, F.; Fischle, W.; Wenzel, D.; Agafonov, D. E.; Samatov, T. R.; Wisniewski, J. R.; Jedrusik-Bode, M.: HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in Caenorhabditis elegans germ line. Molecular and Cellular Biology 29 (13), S. 3700 - 3709 (2009)
90.
Zeitschriftenartikel
Wolf, E.; Kastner, B.; Deckert, J.; Merz, C.; Stark, H.; Lührmann, R.: Exon, intron and splice site locations in the spliceosomal B complex. EMBO Journal 28, S. 2283 - 2292 (2009)
91.
Zeitschriftenartikel
Wahl, M. C.; Will, C. L.; Lührmann, R.: The spliceosome: design principles of a dynamic RNP machine. Cell 136 (4), S. 701 - 718 (2009)
92.
Zeitschriftenartikel
Fabrizio, P.; Dannenberg, J.; Dube, P.; Kastner, B.; Stark, H.; Urlaub, H.; Lührmann, R.: The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Molecular Cell 36 (4), S. 593 - 608 (2009)
93.
Zeitschriftenartikel
Trowitzsch, S.; Weber, G.; Lührmann, R.; Wahl, M. C.: Crystal structure of the Pml1p subunit of the yeast precursor mRNA retention and splicing complex. Journal of Molecular Biology 385 (2), S. 531 - 541 (2009)
94.
Zeitschriftenartikel
Eloranta, M. L.; Lövgren, T.; Finke, D.; Mathsson, L.; Rönnelid, J.; Kastner, B.; Alm, G.; Rönnblom, L.: Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells. Arthritis & Rheumatism 60, S. 2418 - 2427 (2009)
95.
Zeitschriftenartikel
Herold, N.; Will, C. L.; Wolf, E.; Kastner, B.; Urlaub, H.; Lührmann, R.: Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Molecular and Cellular Biology 29 (1), S. 281 - 301 (2009)
96.
Zeitschriftenartikel
Kofler, M.; Schuemann, M.; Merz, C.; Kosslick, D.; Schlundt, A.; Tannert, A.; Schaefer, M.; Lührmann, R.; Krause, E.; Freund, C.: Proline-rich sequence recognition I: Marking GYF and WW domain assembly sites in early spliceosomal complexes. Molecular and Cellular Proteomics 8, S. 2461 - 2473 (2009)
97.
Zeitschriftenartikel
Kuhn, A. N.; van Santen, M. A.; Schwienhorst, A.; Urlaub, H.; Lührmann, R.: Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA 15 (1), S. 153 - 175 (2009)
98.
Zeitschriftenartikel
Lührmann, R.; Stark, H.: Structural mapping of spliceosomes by electron microscopy. Current Opinion in Structural Biology 19, S. 96 - 102 (2009)
99.
Zeitschriftenartikel
Pena, V.; Jovin, S. M.; Fabrizio, P.; Orlowski, J.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Molecular Cell 35 (4), S. 454 - 466 (2009)
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