Publikationen
Zeitschriftenartikel (259)
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ZeitschriftenartikelPathogenic abnormal splicing due to intronic deletions that induce biophysical space constraint for spliceosome assembly. American Journal of Human Genetics 105 (3) (2019)
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ZeitschriftenartikelSmu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications 10 (1) (2019)
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ZeitschriftenartikelStructural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology (2019)
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ZeitschriftenartikelMultiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research 46 (22), S. 12126 - 12138 (2018)
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ZeitschriftenartikelDisrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications 9 (2018)
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ZeitschriftenartikelThe Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation. Nucleic Acids Research 46 (7), S. 3774 - 3790 (2018)
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ZeitschriftenartikelStructural basis of splicing modulation by antitumor macrolide compounds. Molecular Cell 70 (2), S. 265 - 273 (2018)
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ZeitschriftenartikelPrp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell 69 (6), S. 979 - 992 (2018)
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ZeitschriftenartikelStructure and conformational dynamics of the human spliceosomal Bact complex. Cell 172 (3), S. 454 - 464, e1-e5 (2018)
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ZeitschriftenartikelYeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing. RNA 23 (12), S. 1770 - 1779 (2017)
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ZeitschriftenartikelThe RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development 31 (23-24), S. 2416 - 2429 (2017)
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ZeitschriftenartikelCryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), S. 701 - 713, e1 - e4 (2017)
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ZeitschriftenartikelStructural basis for λN-dependent processive transcription antitermination. Nature Microbiology 2 (7), 17062 (2017)
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ZeitschriftenartikelRegulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2. Nucleic Acids Research 45 (7), S. 4068 - 4080 (2017)
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ZeitschriftenartikelIdentification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 6 (2017)
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ZeitschriftenartikelCryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), S. 318 - 323 (2017)
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ZeitschriftenartikelStructural insights into the mechanism of the DEAH-box RNA helicase Prp43. eLife 6 (2017)
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ZeitschriftenartikelSUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 45 (11), S. 6729 - 6745 (2017)
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ZeitschriftenartikelMolecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 64 (2), S. 307 - 319 (2016)
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ZeitschriftenartikelMolecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), S. 1399 - 1405 (2016)
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ZeitschriftenartikelATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 22 (9), S. 1329 - 1337 (2016)
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ZeitschriftenartikelA protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA 22 (9), S. 1427 - 1440 (2016)
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ZeitschriftenartikelU6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III. Scientific Reports 6 (2016)
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ZeitschriftenartikelA spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 7 (2016)
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ZeitschriftenartikelThe target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 5 (2016)
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ZeitschriftenartikelMolecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), S. 1416 - 1420 (2016)
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ZeitschriftenartikelProtein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology 13 (3), S. 320 - 330 (2016)
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ZeitschriftenartikelMultiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 22 (2), S. 265 - 277 (2016)
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ZeitschriftenartikelStructural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 72 (2), S. 112 - 120 (2016)
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ZeitschriftenartikelRational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), S. 10190 - 10197 (2016)
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ZeitschriftenartikelThe large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 29 (24), S. 2576 - 2587 (2015)
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ZeitschriftenartikelProtein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 34 (24), S. 3059 - 3073 (2015)
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ZeitschriftenartikelDynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 11 (9) (2015)
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ZeitschriftenartikelStable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 21 (11) (2015)
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ZeitschriftenartikelHDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 125 (9), S. 3572 - 3584 (2015)
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ZeitschriftenartikelSnapshot: Spliceosome dynamics III. Cell 162 (3) (2015)
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ZeitschriftenartikelSnapShot: Spliceosome dynamics II. Cell 162 (2), S. 456 - 456.e1 (2015)
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ZeitschriftenartikelA composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife 4 (2015)
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ZeitschriftenartikelSnapShot: Spliceosome dynamics I. Cell 161 (6) (2015)
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ZeitschriftenartikelThe RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 22 (2) (2015)
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ZeitschriftenartikelThe G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development 29 (1), S. 94 - 107 (2015)
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ZeitschriftenartikelIdentification of small molecule inhibitors of pre-mRNA splicing. The Journal of Biological Chemistry 289 (50), S. 34683 - 34698 (2014)
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ZeitschriftenartikelArgonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proceedings of the National Academy of Sciences of the United States of America 111 (44), S. 15622 - 15629 (2014)
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ZeitschriftenartikelPhoto-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins. Nature Methods 11 (10), S. 1064 - 1070 (2014)
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ZeitschriftenartikelCooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology 21 (10), S. 911 - 918 (2014)
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ZeitschriftenartikelStructural and functional analysis of the human spliceosomal DEAD-box helicase Prp28. Acta Crystallographica D 70 (6), S. 1622 - 1630 (2014)
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ZeitschriftenartikelNovel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 11 (4), S. 298 - 312 (2014)
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ZeitschriftenartikelMass spectrometry–based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count. RNA 20 (3), S. 406 - 420 (2014)
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ZeitschriftenartikelPhosphorylation drives a dynamic switch in serine/arginine-rich proteins. Structure 21 (12), S. 2162 - 2174 (2013)
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ZeitschriftenartikelRNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. EMBO Journal 32 (21), S. 2804 - 2818 (2013)
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ZeitschriftenartikelThe Prp19 complex directly functions in mitotic spindle assembly. PLoS One 8 (9) (2013)
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ZeitschriftenartikelInhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 341 (6141), S. 80 - 84 (2013)
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ZeitschriftenartikelMolecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system. RNA 19 (7), S. 902 - 915 (2013)
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ZeitschriftenartikelStructural basis for dual roles of Aar2p in U5 snRNP assembly. Genes and Development 27 (5), S. 525 - 540 (2013)
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ZeitschriftenartikelDissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes and Development 27 (4) (2013)
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ZeitschriftenartikelThe Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 26 (23), S. 2422 - 2434 (2012)
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ZeitschriftenartikelEmerging views about the molecular structure of the spliceosomal catalytic center. RNA Biology 9 (11) (2012)
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ZeitschriftenartikelStructural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America 109 (43), S. 17418 - 17423 (2012)
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ZeitschriftenartikelMolecular architecture of Zinc chelating small molecules that inhibit spliceosome assembly at an early stage. RNA 18 (9), S. 1605 - 1611 (2012)
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ZeitschriftenartikelBox H/ACA snoRNAs are preferred substrates for the trimethylguanosine synthase in the divergent unicellular eukaryote Trichomonas vaginalis. RNA 18 (9), S. 1656 - 1665 (2012)
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ZeitschriftenartikelRetention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 3 (2012)
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ZeitschriftenartikelAntisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex. RNA 18 (7), S. 1347 - 1357 (2012)
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ZeitschriftenartikelCwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal 31 (6), S. 1591 - 1604 (2012)
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ZeitschriftenartikelPsoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem 13 (5), S. 640 - 644 (2012)
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ZeitschriftenartikelDynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 45 (4), S. 567 - 580 (2012)
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ZeitschriftenartikelPrp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA 18 (6), S. 1244 - 1256 (2012)
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ZeitschriftenartikelCrystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 31 (9), S. 2222 - 2234 (2012)
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ZeitschriftenartikelStructural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. RNA 17 (9), S. 1655 - 1663 (2011)
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ZeitschriftenartikelSemiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology 31 (13), S. 2667 - 2682 (2011)
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ZeitschriftenartikelSynthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. Journal of Biological Chemistry 286 (12), S. 10126 - 10136 (2011)
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ZeitschriftenartikelHSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 331 (6018), S. 760 - 764 (2011)
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Zeitschriftenartikel3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core. Molecular Cell 40 (6), S. 927 - 938 (2010)
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ZeitschriftenartikelCharacterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 16 (12), S. 2384 - 2403 (2010)
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ZeitschriftenartikelAn approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy. Structure 18 (6), S. 667 - 676 (2010)
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ZeitschriftenartikelMolecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology 30 (9), S. 2105 - 2119 (2010)
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ZeitschriftenartikelMapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry. Nucleic Acids Research 38 (16), S. 5581 - 5593 (2010)
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ZeitschriftenartikelExon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Molecular Cell 38 (2), S. 223 - 235 (2010)
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ZeitschriftenartikelThe crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS ONE 5, e10013 (2010)
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ZeitschriftenartikelCoilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nature Structural and Molecular Biology 17 (4), S. 403 - 409 (2010)
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ZeitschriftenartikelAn ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Molecular Cell 37 (6), S. 821 - 833 (2010)
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ZeitschriftenartikelHuman PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural and Molecular Biology 17 (2), S. 216 - 222 (2010)
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ZeitschriftenartikelThe intronic splicing code: Multiple factors involved in ATM pseudoexon definition. The EMBO Journal 29, S. 749 - 760 (2010)
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ZeitschriftenartikelDetermination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring. Analytical Chemistry 82 (7), S. 2784 - 2796 (2010)
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ZeitschriftenartikelFunctional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO Journal 29, S. 4172 - 4184 (2010)
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ZeitschriftenartikelReconstitution of both steps of S. cerevisiae splicing with purified spliceosomal components. Nature Structural and Molecular Biology 16 (12), S. 1237 - 1243 (2009)
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ZeitschriftenartikelIn vivo expression and purification of aptamer-tagged small RNA regulators. Nucleic Acids Research 37 (20), e133 (2009)
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ZeitschriftenartikelHIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in Caenorhabditis elegans germ line. Molecular and Cellular Biology 29 (13), S. 3700 - 3709 (2009)
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ZeitschriftenartikelExon, intron and splice site locations in the spliceosomal B complex. EMBO Journal 28, S. 2283 - 2292 (2009)
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ZeitschriftenartikelThe spliceosome: design principles of a dynamic RNP machine. Cell 136 (4), S. 701 - 718 (2009)
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ZeitschriftenartikelThe evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Molecular Cell 36 (4), S. 593 - 608 (2009)
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ZeitschriftenartikelCrystal structure of the Pml1p subunit of the yeast precursor mRNA retention and splicing complex. Journal of Molecular Biology 385 (2), S. 531 - 541 (2009)
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ZeitschriftenartikelRegulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells. Arthritis & Rheumatism 60, S. 2418 - 2427 (2009)
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ZeitschriftenartikelConservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Molecular and Cellular Biology 29 (1), S. 281 - 301 (2009)
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ZeitschriftenartikelProline-rich sequence recognition I: Marking GYF and WW domain assembly sites in early spliceosomal complexes. Molecular and Cellular Proteomics 8, S. 2461 - 2473 (2009)
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ZeitschriftenartikelStalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA 15 (1), S. 153 - 175 (2009)
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ZeitschriftenartikelStructural mapping of spliceosomes by electron microscopy. Current Opinion in Structural Biology 19, S. 96 - 102 (2009)
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ZeitschriftenartikelCommon design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Molecular Cell 35 (4), S. 454 - 466 (2009)
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ZeitschriftenartikelDynamic regulation of alternative splicing by silencers that modulate 5´ splice site competition. Cell 135 (7), S. 1224 - 1236 (2008)
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ZeitschriftenartikelStructure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy. RNA 14, S. 2528 - 2537 (2008)