Publikationen
Zeitschriftenartikel (120)
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1.ZeitschriftenartikelActive role of elongation factor G in maintaining the mRNA reading frame during translation. Science Advances 5 (12), eaax8030 (2019)
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2.ZeitschriftenartikelConverting GTP hydrolysis into motion: Versatile translational elongation factor G. Biological Chemistry 401 (1), S. 131 - 142 (2019)
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3.ZeitschriftenartikelThermodynamic control of −1 programmed ribosomal frameshifting. Nature Communications 10 (2019)
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4.ZeitschriftenartikelTranslational recoding: Canonical translation mechanisms reinterpreted. Nucleic Acids Research (2019)
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5.ZeitschriftenartikelMechanisms and biomedical implications of –1 programmed ribosome frameshifting on viral and bacterial mRNAs. FEBS Letters 593 (13), S. 1468 - 1482 (2019)
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6.ZeitschriftenartikelThe epitranscriptome in translation regulation: mRNA and tRNA modifications as the two sides of the same coin? FEBS Letters 593 (13), S. 1483 - 1493 (2019)
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7.ZeitschriftenartikelEF-G-induced ribosome sliding along the noncoding mRNA. Science Advances 5 (6) (2019)
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8.ZeitschriftenartikelModulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance. Nucleic Acids Research 47 (10), S. 5210 - 5222 (2019)
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9.ZeitschriftenartikelTranslation termination depends on the sequential ribosomal entry of eRF1 and eRF3. Nucleic Acids Research 47 (9), S. 4798 - 4813 (2019)
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10.ZeitschriftenartikelBroad range of missense error frequencies in cellular proteins. Nucleic Acids Research 47 (6), S. 2932 - 2945 (2019)
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11.ZeitschriftenartikelElongation factor Tu's nucleotide binding is governed by a thermodynamic landscape unique among bacterial translation factors. Journal of the American Chemical Society 141 (26), S. 10236 - 10246 (2019)
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12.ZeitschriftenartikelDecomposition of time-dependent fluorescence signals reveals codon-specific kinetics of protein synthesis. Nucleic Acids Research 46 (22), e130 (2018)
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13.ZeitschriftenartikelSmall synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting. Nucleic Acids Research 46 (16), S. 8079 - 8089 (2018)
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14.ZeitschriftenartikelFunctions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2. Genes and Development 32 (17-18), S. 1226 - 1241 (2018)
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15.ZeitschriftenartikelVisualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1. Nature Communications 9 (2018)
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16.ZeitschriftenartikelCotranslational protein targeting to the membrane: Nascent-chain transfer in a quaternary complex formed at the translocon. Scientific Reports 8 (1) (2018)
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17.ZeitschriftenartikelCo-translational folding trajectory of the HemK helical domain. Biochemistry 57 (25), S. 3460 - 3464 (2018)
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18.ZeitschriftenartikelDynamics of ribosomes and release factors during translation termination in E-coli. eLife 7 (2018)
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19.ZeitschriftenartikelTranslation initiation in bacterial polysomes through ribosome loading on a standby site on a highly translated mRNA. Proceedings of the National Academy of Sciences of the United States of America 115 (17), S. 4411 - 4416 (2018)
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20.ZeitschriftenartikelTranslation in prokaryotes. Cold Spring Harbor Perspectives in Biology 10 (9) (2018)
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21.ZeitschriftenartikelDeciphering the reading of the genetic code by near-cognate tRNA. Proceedings of the National Academy of Sciences of the United States of America 115 (12) (2018)
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22.ZeitschriftenartikelSignal recognition particle binds to translating ribosomes before emergence of a signal anchor sequence. Nucleic Acids Research 45 (20), S. 11858 - 11866 (2017)
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23.ZeitschriftenartikelStructural basis for polyproline-mediated ribosome stalling and rescue by the translation elongation factor EF-P. Molecular Cell 68 (3), S. 515 - 527 (2017)
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24.ZeitschriftenartikelNon-canonical binding site for bacterial initiation factor 3 on the large ribosomal subunit. Cell Reports 20 (13) (2017)
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25.ZeitschriftenartikelEffect of fusidic acid on the kinetics of molecular motions during EF-G-induced translocation on the ribosome. Scientific Reports 7 (2017)
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26.ZeitschriftenartikelAn antimicrobial peptide that inhibits translation by trapping release factor trap. Nature Structural and Molecular Biology 24 (9), S. 752 - 757 (2017)
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27.ZeitschriftenartikelRibosome rearrangements at the onset of translational bypassing. Science Advances 3 (6) (2017)
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28.ZeitschriftenartikelConditional switch between frameshifting regimes upon translation of dnaX mRNA. Molecular Cell 66 (4) (2017)
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29.ZeitschriftenartikelSignal recognition particle prevents N-terminal processing of bacterial membrane proteins. Nature Communications 8 (2017)
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30.ZeitschriftenartikelThio-modification of tRNA at the wobble position as regulator of the kinetics of decoding and translocation on the ribosome. Journal of the American Chemical Society 139 (16), S. 5857 - 5864 (2017)
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31.ZeitschriftenartikelRibosome dynamics during decoding. Philosophical Transactions of the Royal Society B 372 (1716), 20160182 (2017)
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32.ZeitschriftenartikelCo-translational protein folding: Progress and methods. Current Opinion in Structural Biology 42, S. 83 - 89 (2017)
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33.ZeitschriftenartikelThe pathway to GTPase activation of elongation factor SelB on the ribosome. Nature 540 (7631), S. 80 - 85 (2016)
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34.ZeitschriftenartikelNSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. The EMBO Journal 35 (19), S. 2104 - 2119 (2016)
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35.ZeitschriftenartikelThe bacterial SRP receptor, FtsY, is activated on binding to the translocon. Molecular Microbiology 102 (1), S. 152 - 167 (2016)
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36.ZeitschriftenartikelKinetics of spontaneous and EF-G-accelerated rotation of ribosomal subunits. Cell Reports 16 (8), S. 2187 - 2196 (2016)
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37.ZeitschriftenartikelElectrostatics and intrinsic disorder drive translocon binding of the SRP receptor FtsY. Angewandte Chemie International Edition 55 (33), S. 9544 - 9547 (2016)
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38.ZeitschriftenartikelTranslational GTPases. Biopolymers 105 (8), S. 463 - 475 (2016)
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39.ZeitschriftenartikelThe ribosome in action: Tuning of translational efficiency and protein folding. Protein Science 25 (8), S. 1390 - 1406 (2016)
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40.ZeitschriftenartikelEssential structural elements in tRNAPro for EF-P-mediated alleviation of translation stalling. Nature Communications 7 (2016)
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41.ZeitschriftenartikelProtein elongation, co-translational folding and targeting. Journal of Molecular Biology 428 (10, P. B), S. 2165 - 2185 (2016)
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42.ZeitschriftenartikelInhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding. Proceedings of the National Academy of Sciences of the United States of America 113 (16) (2016)
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43.ZeitschriftenartikelChoreography of molecular movements during ribosome progression along mRNA. Nature Structural and Molecular Biology 23 (4), S. 342 - 348 (2016)
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44.ZeitschriftenartikelSynonymous codons direct cotranslational folding toward different protein conformations. Molecular Cell 61 (3), S. 341 - 351 (2016)
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45.ZeitschriftenartikeltRNA wobble modifications and protein homeostasis. Translation 4 (1) (2016)
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46.ZeitschriftenartikelTranslocation as continuous movement through the ribosome. RNA Biology 13 (12), S. 1197 - 1203 (2016)
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47.ZeitschriftenartikelDirectional transition from initiation to elongation in bacterial translation. Nucleic Acids Research 43 (22), S. 10700 - 10712 (2015)
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48.ZeitschriftenartikelTwo-state intramolecular charge transfer (ICT) with 3,5-dimethyl-4(dimethylamino)benzonitrile (MMD) and its meta-isomer mMMD. Ground state amino twist not essential for ICT. Journal of Physical Chemistry A 119 (49), S. 11820 - 11836 (2015)
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49.ZeitschriftenartikelActivities of the peptidyl transferase center of ribosomes lacking protein L27. RNA 21 (12), S. 2047 - 2052 (2015)
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50.ZeitschriftenartikelCotranslational protein folding on the ribosome monitored in real time. Science 250 (6264) (2015)
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51.ZeitschriftenartikelEntropic contribution of elongation factor P to proline positioning at the catalytic center of the ribosome. Journal of the American Chemical Society 137 (40), S. 12997 - 13006 (2015)
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52.ZeitschriftenartikelRibosome binding induces repositioning of the signal recognition particle receptor on the translocon. Journal of Cell Biology 211 (1) (2015)
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53.ZeitschriftenartikelPartitioning between recoding and termination at a stop codon-selenocysteine insertion sequence. Nucleic Acids Research 43 (13), S. 6426 - 6438 (2015)
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54.ZeitschriftenartikelFluctuations between multiple EF-G-induced chimeric tRNA states during translocation on the ribosome. Nature Communications 6 (2015)
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55.ZeitschriftenartikelMajor reorientation of tRNA substrates defines specificity of dihydrouridine synthases. Proceedings of the National Academy of Sciences of the United States of America 112 (19), S. 6033 - 6037 (2015)
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56.ZeitschriftenartikelChanged in translation: mRNA recoding by −1 programmed ribosomal frameshifting. Trends in Biochemical Sciences 40 (5), S. 265 - 274 (2015)
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57.ZeitschriftenartikelStructure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM. Nature 520 (7548), S. 567 - 570 (2015)
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58.ZeitschriftenartikelStudying macromolecular complex stoichiometries by peptide-based mass spectrometry. Proteomics 15 (5-6), S. 862 - 879 (2015)
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59.ZeitschriftenartikelAmicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Molecular Cell 56 (4), S. 531 - 540 (2014)
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60.ZeitschriftenartikelDeducing the kinetics of protein synthesis in vivo from the transition rates measured in vitro. PLoS Computational Biology 10 (10) (2014)
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61.ZeitschriftenartikelLateral opening of the bacterial translocon on ribosome binding and signal peptide insertion. Nature Communications 5 (2014)
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62.ZeitschriftenartikelRibosome-induced tuning of GTP hydrolysis by a translational GTPase. Proceedings of the National Academy of Sciences of the United States of America 111 (40), S. 14418 - 14423 (2014)
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63.ZeitschriftenartikelSynchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis. BioEssays 36 (10), S. 908 - 918 (2014)
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64.ZeitschriftenartikelStructural basis for the inhibition of the eukaryotic ribosome. Nature 513 (7519), S. 517 - 522 (2014)
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65.ZeitschriftenartikelHigh-efficiency translational bypassing of non-coding nucleotides specified by mRNA structure and nascent peptide. Nature communications 5 (2014)
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66.ZeitschriftenartikelProgrammed –1 frameshifting by kinetic partitioning during impeded translocation. Cell 157 (7), S. 1619 - 1631 (2014)
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67.ZeitschriftenartikelInterplay between trigger factor and other protein biogenesis factors on the ribosome. Nature Communications 5 (2014)
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68.ZeitschriftenartikelGTP hydrolysis by EF‐G synchronizes tRNA movement on small and large ribosomal subunits. EMBO Journal 33 (9), S. 1073 - 1085 (2014)
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69.ZeitschriftenartikelTiming of GTP binding and hydrolysis by translation termination factor RF3. Nucleic Acids Research 42 (3), S. 1812 - 1820 (2014)
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70.ZeitschriftenartikelEnergy barriers and driving forces in tRNA translocation through the ribosome. Nature Structural and Molecular Biology 20 (12), S. 1390 - 1396 (2013)
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71.ZeitschriftenartikelElongation factor P: Function and effects on bacterial fitness. Biopolymers 99 (11), S. 837 - 845 (2013)
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72.ZeitschriftenartikelA kinetic safety gate controlling the delivery of unnatural amino acids to the ribosome. Journal of the American Chemical Society 135 (45) (2013)
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73.ZeitschriftenartikelThe ribosome as a versatile catalyst: Reactions at the peptidyl transferase center. Current Opinion in Structural Biology 23 (4), S. 595 - 602 (2013)
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74.ZeitschriftenartikeltRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding. Proceedings of the National Academy of Sciences of the United States of America 110 (30), S. 12289 - 12294 (2013)
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75.ZeitschriftenartikelTranslocation in action. Science 340 (6140), S. 1534 - 1535 (2013)
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76.ZeitschriftenartikelDual use of GTP hydrolysis by elongation factor G on the ribosome. Translation 1 (1), e24315 (2013)
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77.ZeitschriftenartikelEvolution of the protein stoichiometry in the L12 stalk of bacterial and organellar ribosomes. Nature Communications 4 (2013)
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78.ZeitschriftenartikelEF-P is essential for rapid synthesis of proteins containing consecutive proline residues. Science 339 (6115), S. 85 - 88 (2013)
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79.ZeitschriftenartikelDynamic switch of the signal recognition particle from scanning to targeting. Nature Structural and Molecular Biology 19 (12), S. 1332 - 1337 (2012)
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80.ZeitschriftenartikelNovel insights into the architecture and protein interaction network of yeast eIF3. RNA 18 (12), S. 2306 - 2319 (2012)
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81.ZeitschriftenartikelThermodynamics of the GTP-GDP operated conformational switch of selenocysteine-specific translation factor SelB. Journal of Biological Chemistry 287 (33), S. 27906 - 27912 (2012)
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82.ZeitschriftenartikelKinetic control of translation initiation in bacteria. Critical Reviews in Biochemistry and Molecular Biology 47 (4), S. 334 - 348 (2012)
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83.ZeitschriftenartikelImpact of methylations of m2G966/m5C967 in 16S rRNA on bacterial fitness and translation initiation. Nucleic Acids Research 40 (16), S. 7885 - 7895 (2012)
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84.ZeitschriftenartikelRibosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proceedings of the National Academy of Sciences of the United States of America 109 (6), S. 2102 - 2107 (2012)
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85.ZeitschriftenartikelReal-time assembly landscape of bacterial 30S translation initiation complex. Nature Structural and Molecular Biology 19 (6), S. 609 - 615 (2012)
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86.ZeitschriftenartikelAminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for legionella pneumophila effector glucosyltransferases. PLoS One 6 (12) (2011)
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87.ZeitschriftenartikelEvolutionary optimization of speed and accuracy of decoding on the ribosome. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 366 (1580), S. 2979 - 2986 (2011)
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88.ZeitschriftenartikelThe structure of helix 89 of 23S rRNA is important for peptidyl transferase function of Escherichia coli ribosome. FEBS Letters 585 (19), S. 3073 - 3078 (2011)
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89.ZeitschriftenartikelDifferent substrate-dependent transition states in the active site of the ribosome. Nature 476, S. 351 - 354 (2011)
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90.ZeitschriftenartikelThe cryo-EM structure of a complete 30S translation initiation complex from Escherichia coli. PLoS Biology 9 (7), e1001095 (2011)
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91.ZeitschriftenartikelDistortion of tRNA upon near-cognate codon recognition on the ribosome. Journal of Biological Chemistry 286 (10), S. 8158 - 8164 (2011)
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92.ZeitschriftenartikelThe ribosome as a molecular machine: The mechanism of tRNA–mRNA movement in translocation. Biochemical Society Transactions 39, S. 658 - 662 (2011)
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93.ZeitschriftenartikelGenauigkeit und Geschwindigkeit der Proteinsynthese. Biospektrum 17 (4), S. 389 - 392 (2011)
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94.ZeitschriftenartikelOptimization of speed and accuracy of decoding in translation. The EMBO Journal 29 (21), S. 3701 - 3709 (2010)
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95.ZeitschriftenartikelThe ribosome-bound initiation factor 2 recruits initiator tRNA to the 30S initiation complex. EMBO Reports 11 (4), S. 312 - 316 (2010)
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96.ZeitschriftenartikelProtein synthesis meets ABC ATPases: new roles for Rli1/ABCE1. EMBO Reports 11 (3), S. 143 - 144 (2010)
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97.ZeitschriftenartikelThermodynamic and kinetic framework of selenocysteyl-tRNA(Sec) recognition by elongation factor SelB. The Journal of Biological Chemistry 285 (5), S. 3014 - 3020 (2010)
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98.ZeitschriftenartikelMutations at the accommodation gate of the ribosome impair RF2-dependent translation termination. RNA 16 (9), S. 1848 - 1853 (2010)
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99.ZeitschriftenartikelThe crystal structure of unmodified tRNAPhe from Escherichia coli. Nucleic Acids Research 38 (12), S. 4154 - 4162 (2010)