Publikationen

Zeitschriftenartikel (99)

  1. Zeitschriftenartikel
    Kastner, B.; Will, C. L.; Stark, H.; Lührmann, R.: Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 11 (11), a032417 (2019)
  2. Zeitschriftenartikel
    Watson, E. R.; Grace, C. R. R.; Zhang, W.; Miller, D. J.; Davidson, I. F.; Prabu, J. R.; Yu, S.; Bolhuis, D. L.; Kulko, E. T.; Vollrath, R. et al.; Haselbach, D.; Stark, H.; Peters, J. M.; Brown, N. G.; Sidhu, S. S.; Schulman, B. A.: Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proceedings of the National Academy of Sciences of the United States of America 116 (35), S. 17280 - 17289 (2019)
  3. Zeitschriftenartikel
    Prajapati, S.; Haselbach, D.; Wittig, S.; Patel, M. S.; Chari, A.; Schmidt, C.; Stark, H.; Tittmann, K.: Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure 27 (7), S. 1124 - 1136 (2019)
  4. Zeitschriftenartikel
    Watson, E. R.; Brown, N. G.; Peters, J. M.; Stark, H.; Schulman, B. A.: Posing the APC/C E3 ubiquitin ligase to orchestrate cell division. Trends in Cell Biology 29 (2), S. 117 - 134 (2019)
  5. Zeitschriftenartikel
    Renaud, J. P.; Chari, A.; Ciferri, C.; Liu, W.; Rémigy, H. W.; Stark, H.; Wiesmann, C.: Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery 17 (7), S. 471 - 492 (2018)
  6. Zeitschriftenartikel
    Haselbach, D.; Komarov, I.; Agafonov, D. E.; Hartmuth, K.; Graf, B.; Dybkov, O.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Structure and conformational dynamics of the human spliceosomal Bact complex. Cell 172 (3), S. 454 - 464, e1-e5 (2018)
  7. Zeitschriftenartikel
    Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), S. 701 - 713, e1 - e4 (2017)
  8. Zeitschriftenartikel
    Haselbach, D.; Schrader, J.; Lambrecht, F.; Henneberg, F.; Chari, A.; Stark, H.: Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications 8 (2017)
  9. Zeitschriftenartikel
    Rodnina, M. V.; Fischer, N.; Maracci, C.; Stark, H.: Ribosome dynamics during decoding. Philosophical Transactions of the Royal Society B 372 (1716), 20160182 (2017)
  10. Zeitschriftenartikel
    Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), S. 318 - 323 (2017)
  11. Zeitschriftenartikel
    Fischer, N.; Neumann, P.; Bock, l. V.; Maracci, C.; Wang, Z.; Paleskava, A.; Konevega, A. L.; Schröder, G. F.; Grubmüller, H.; Ficner, R. et al.; Rodnina, M. V.; Stark, H.: The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature 540 (7631), S. 80 - 85 (2016)
  12. Zeitschriftenartikel
    Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), S. 1399 - 1405 (2016)
  13. Zeitschriftenartikel
    Paknia, E.; Chari, A.; Stark, H.; Fischer, U.: The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports 16 (12) (2016)
  14. Zeitschriftenartikel
    Agafonov, D. E.; van Santen, M.; Kastner, B.; Dube, P.; Will, C. L.; Urlaub, H.; Lührmann, R.: ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 22 (9), S. 1329 - 1337 (2016)
  15. Zeitschriftenartikel
    Hons, M.; Huis in ‘t Veld, P. J.; Kaesler, J.; Rombaut, P.; Schleiffer, A.; Herzog, F.; Stark, H.; Peters, J. M.: Topology and structure of an engineered human cohesin complex bound to Pds5B. Nature Communications 7 (2016)
  16. Zeitschriftenartikel
    Yamaguchi, M.; VanderLinden, R.; Weissmann, F.; Qiao, R.; Dube, P.; Brown, N. G.; Haselbach, D.; Zhang, W.; Sidhu, S. S.; Peters, J. M. et al.; Stark, H.; Schulman, B. A.: Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation. Molecular Cell 63 (4), S. 593 - 607 (2016)
  17. Zeitschriftenartikel
    Schrader, J.; Henneberg, F.; Mata, R. A.; Tittmann, K.; Schneider, T. R.; Stark, H.; Bourenkov, G.; Chari, A.: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science 353 (6299), S. 594 - 598 (2016)
  18. Zeitschriftenartikel
    Brown, N. G.; VanderLinden, R.; Watson, E. R.; Weissmann, F.; Ordureau, A.; Wu, K. P.; Zhang, W.; Yu, S.; Mercredi, P. Y.; Harrison, J. S. et al.; Davidson, I. F.; Qiao, R. P.; Lu, Y.; Dube, P.; Brunner, M. R.; Grace, C. R. R.; Miller, D. J.; Haselbach, D.; Jarvis, M. A.; Yamaguchi, M.; Yanishevski, D.; Petzold, G.; Sidhu, S. S.; Kuhlman, B.; Kirschner, M. W.; Harper, J. W.; Peters, J. M.; Stark, H.; Schulman, B. A.: Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. Cell 165 (6), S. 1440 - 1453 (2016)
  19. Zeitschriftenartikel
    Qiao, R. P.; Weissmann, F.; Yamaguchi, M.; Brown, N. G.; VanderLinden, R.; Imre, R.; Jarvis, M. A.; Brunner, M. R.; Davidson, I. F.; Litos, G. et al.; Haselbach, D.; Mechtler, K.; Stark, H.; Schulman, B. A.; Peters, J. M.: Mechanism of APC/C-CDC20 activation by mitotic phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 113 (19) (2016)
  20. Zeitschriftenartikel
    Weissmann, F.; Petzold, G.; VanderLinden, R.; in'T Veld, P. J. H.; Brown, N. G.; Lampert, F.; Westermann, S.; Stark, H.; Schulman, B. A.; Peters, J. M.: biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes. Proceedings of the National Academy of Sciences of the United States of America 113 (19) (2016)
  21. Zeitschriftenartikel
    Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.; Urlaub, H.; Lührmann, R.; Stark, H.: Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), S. 1416 - 1420 (2016)
  22. Zeitschriftenartikel
    Stark, H.; Chari, A.: Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy. Microscopy 65 (1), S. 23 - 34 (2016)
  23. Zeitschriftenartikel
    Pleiner, T.; Bates, M.; Trakhanov, S.; Lee, C. T.; Schliep, J. E.; Chug, H.; Böhning, M.; Stark, H.; Urlaub, H.; Görlich, D.: Nanobodies: Site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation. eLife 4 (2015)
  24. Zeitschriftenartikel
    Chari, A.; Haselbach, D.; Kirves, J. M.; Ohmer, J.; Paknia, E.; Fischer, N.; Ganichkin, O.; Moller, V.; Frye, J. J.; Petzold, G. et al.; Jarvis, M.; Tietzel, M.; Grimm, C.; Peters, J. M.; Schulman, B. A.; Tittmann, K.; Markl, J.; Fischer, U.; Stark, H.: ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods 12 (9), S. 859 - 865 (2015)
  25. Zeitschriftenartikel
    Hauer, F.; Gerle, C.; Fischer, N.; Oshima, A.; Shinzawa-Itoh, K.; Shimada, S.; Yokoyama, K.; Fujiyoshi, Y.; Stark, H.: GraDeR: Membrane protein complex preparation for single-particle cryo-EM. Structure 23 (9), S. 1769 - 1775 (2015)
  26. Zeitschriftenartikel
    Lin , Y. J.; Liu, W.; Stark, H.; Huang, C. T.: Expression of enterovirus 71 virus-like particles in transgenic enoki (Flammulina velutipes). Applied Microbiology and Biotechnology 99 (16), S. 6765 - 6774 (2015)
  27. Zeitschriftenartikel
    Martinez-Rucobo, F. W.; Kohler, R.; Waterbeemd, M. v. d.; Heck, A. J.; Hemann, M.; Herzog, F.; Stark, H.; Cramer, P.: Molecular basis of transcription-coupled pre-mRNA capping. Molecular Cell 58 (6), S. 1079 - 1089 (2015)
  28. Zeitschriftenartikel
    Neuenkirchen, N.; Englbrecht, C.; Ohmer, J.; Ziegenhals, T.; Chari, A.; Fischer, U.: Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization. EMBO Journal 34 (14) (2015)
  29. Zeitschriftenartikel
    Brown, N. G.; VanderLinden, R.; Watson, E. R.; Qiao, R. P.; Grace, C. R. R.; Yamaguchi, M.; Weissmann, F.; Frye, J. J.; Dube, P.; Cho, S. E. et al.; Actis, M. L.; Rodrigues, P.; Fujii, N.; Peters, J. M.; Stark, H.; Schulman, B. A.: RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. Proceedings of the National Academy of Sciences of the United States of America 112 (17) (2015)
  30. Zeitschriftenartikel
    Fischer, N.; Neumann, P.; Konevega, A. L.; Bock, L. V.; Ficner, R.; Rodnina, M. V.; Stark, H.: Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM. Nature 520 (7548), S. 567 - 570 (2015)
  31. Zeitschriftenartikel
    Brown, N. G.; Watson, E. R.; Weissmann, F.; Jarvis, M. A.; VanderLinden, R.; Grace, C.R.R.; Frye, J. J.; Qiao, R.; Dube, P.; Petzold, G. et al.; Cho, S. E.; Alsharif, O.; Bao, J.; Davidson, I.F.; Zheng, J. J.; Nourse, A.; Kurinov, I.; Peters, J. M.; Stark, H.; Schulman, B. A.: Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly. Molecular Cell 56 (2), S. 246 - 260 (2014)
  32. Zeitschriftenartikel
    Liu, Y.; Neumann, P.; Kuhle, B.; Monecke, T.; Schell, S.; Chari, A.; Ficner, R.: Translation initiation factor eIF3b contains a nine-bladed beta-propeller and interacts with the 40S ribosomal subunit. Structure 22 (6), S. 923 - 930 (2014)
  33. Zeitschriftenartikel
    Bock, L. V.; Blau, C.; Schröder, G. F.; Davydov, I. I.; Fischer, N.; Stark, H.; Rodnina, M. V.; Vaiana, A. C.; Grubmüller, H.: Energy barriers and driving forces in tRNA translocation through the ribosome. Nature Structural and Molecular Biology 20 (12), S. 1390 - 1396 (2013)
  34. Zeitschriftenartikel
    Doelker, N.; Blanchet, C. E.; Voss, B.; Haselbach, D.; Kappel, C.; Monecke, T.; Svergun, D. I.; Stark, H.; Ficner, R.; Zachariae, U. et al.; Grubmüller, H.; Dickmanns, A.: Structural determinants and mechanism of mammalian CRM1 allostery. Structure 21 (8), S. 1350 - 1360 (2013)
  35. Zeitschriftenartikel
    Frye, J.; Brown, N. G.; Petzold, G.; Watson, E. R.; Grace, C. R. R.; Nourse, A.; Jarvis, M. A.; Kriwacki, R. W.; Peters, J. M.; Stark, H. et al.; Schulman, B. A.: Electron microscopy structure of human APC/C-CDH1-EMI1 reveals multimodal mechanism of E3 ligase shutdown. Nature Structural and Molecular Biology 20 (7), S. 827 - 835 (2013)
  36. Zeitschriftenartikel
    Hauer, F.; Gerle, C.; Kirves, J. M.; Stark, H.: Automated correlation of single particle tilt pairs for Random Conical Tilt and Orthogonal Tilt Reconstructions. Journal of Structural Biology 181 (2), S. 149 - 154 (2013)
  37. Zeitschriftenartikel
    Grimm, C.; Chari, A.; Pelz, J. P.; Kuper, J.; Kisker, C.; Diederichs, K.; Stark, H.; Schindelin, H.; Fischer, U.: Structural basis of assembly chaperone- mediated snRNP formation. Molecular Cell 49 (4), S. 692 - 703 (2013)
  38. Zeitschriftenartikel
    Monecke, T.; Haselbach, D.; Voß, D.; Russek, A.; Neumann, P.; Thomson, E.; Hurt, E.; Zachariae, U.; Stark, H.; Grubmüller, H. et al.; Dickmanns, A.; Ficner, R.: Structural basis for cooperativity of CRM1 export complex formation. Proceedings of the National Academy of Sciences of the United States of America 110 (3), S. 960 - 965 (2013)
  39. Zeitschriftenartikel
    Khoshnevis, S.; Hauer, F.; Milon, P.; Stark, H.; Ficner, R.: Novel insights into the architecture and protein interaction network of yeast eIF3. RNA 18 (12), S. 2306 - 2319 (2012)
  40. Zeitschriftenartikel
    Uzunova, K.; Dye, B. T.; Schutz, H.; Ladurner, R.; Petzold, G.; Toyoda, Y.; Jarvis, M. A.; Brown, N. G.; Poser, I.; Novatchkova, M. et al.; Mechtler, K.; Hyman, A. A.; Stark, H.; Schulman, B. A.; Peters, J. M.: APC15 mediates CDC20 autoubiquitylation by APC/C-MCC and disassembly of the mitotic checkpoint complex. Nature Structural and Molecular Biology 19 (11), S. 1116 - 1123 (2012)
  41. Zeitschriftenartikel
    Brunotte, L.; Kerber, R.; Shang, W.; Hauer, F.; Hass, M.; Gabriel, M.; Lelke, M.; Busch, C.; Stark, H.; Svergun, D. I. et al.; Betzel, C.; Perbrandt, M.; Guenther, S.: Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. Journal of Biological Chemistry 286 (44), S. 38748 - 38756 (2011)
  42. Zeitschriftenartikel
    Nikolov, M.; Stützer, A.; Mosch, K.; Krasauskas, A.; Soeroes, S.; Stark, H.; Urlaub, H.; Fischle, W.: Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns. Molecular and Cellular Proteomics 10 (11), S. 10.1074/mcp.M110.005371-1 - 10.1074/mcp.M110.005371–16 (2011)
  43. Zeitschriftenartikel
    Buschhorn, B. A.; Petzold, G.; Galova, M.; Dube, P.; Kraft, C.; Herzog, F.; Stark, H.; Peters, J. M.: Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nature Structural and Molecular Biology 18, S. 6 - 13 (2010)
  44. Zeitschriftenartikel
    Golas, M. M.; Sander, B.; Bessonov, S.; Grote, M.; Wolf, E.; Kastner, B.; Stark, H.; Lührmann, R.: 3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core. Molecular Cell 40 (6), S. 927 - 938 (2010)
  45. Zeitschriftenartikel
    Bessonov, S.; Anokhina, M.; Krasauskas, A.; Golas, M. M.; Sander, B.; Will, C. L.; Urlaub, H.; Stark, H.; Lührmann, R.: Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 16 (12), S. 2384 - 2403 (2010)
  46. Zeitschriftenartikel
    Petrovic, A.; Pasqualato, S.; Dube, P.; Krenn, V.; Santaguida, S.; Cittaro, D.; Monzani, S.; Massimiliano, L.; Keller, J.; Tarricone, A. et al.; Maiolica, A.; Stark, H.; Musaccio, A.: The MIS12 complex is a protein interaction hub for outer kinetochore assembly. Journal of Cell Biology 190 (5), S. 835 - 852 (2010)
  47. Zeitschriftenartikel
    Sander, B.; Golas, M. M.; Lührmann, R.; Stark, H.: An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy. Structure 18 (6), S. 667 - 676 (2010)
  48. Zeitschriftenartikel
    Hutchins, J. R. A.; Toyoda, Y.; Hegemann, B.; Poser, I.; Heriche, J. K.; Sykora, M. M.; Augsburg, M.; Hudecz, O.; Buschhorn, B. A.; Bulkescher, J. et al.; Conrad, C.; Comartin, D.; Schleiffer, A.; Sarov, M.; Pozniakovsky, A.; Slabicki, M. M.; Schloissnig, S.; Steinmacher, I.; Leuschner, M.; Ssykor, A.; Lawo, S.; Pelletier, L.; Stark, H.; Nasmyth, K.; Ellenberg, J.; Durbin, R.; Buchholz, F.; Mechtler, K.; Hyman, A. A.; Peters, J. M.: Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 328 (5978), S. 593 - 599 (2010)
  49. Zeitschriftenartikel
    Fischer, N.; Konevega, A. L.; Wintermeyer, W.; Rodnina, M. V.; Stark, H.: Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy. Nature 466 (7304), S. 329 - 333 (2010)
  50. Zeitschriftenartikel
    Richter, F. M.; Sander, B.; Golas, M. M.; Stark, H.; Urlaub, H.: Merging molecular electron microscopy and mass spectrometry by carbon film-assisted endoproteinase digestion. Molecular and Cellular Proteomics 9, S. 1729 - 1741 (2010)
  51. Zeitschriftenartikel
    Uezguen, S.; Akdemir, O.; Hasenpusch, G.; Mauksch, C.; Golas, M. M.; Sander, B.; Stark, H.; Imker, R.; Lutz, J. F.; Rudolph, C.: Characterization of tailor-made copolymers of oligo(ethylene glycol) methyl ether methacrylate and N,N-dimethylaminoethyl methacrylate as nonviral gene transfer agents: Influence of macromolecular structure on gene vector particle properties and transfection efficiency. Biomacromolecules 11 (1), S. 39 - 50 (2010)
  52. Zeitschriftenartikel
    Warkocki, Z.; Odenwälder, P.; Schmitzova, J.; Platzmann, F.; Stark, H.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: Reconstitution of both steps of S. cerevisiae splicing with purified spliceosomal components. Nature Structural and Molecular Biology 16 (12), S. 1237 - 1243 (2009)
  53. Zeitschriftenartikel
    Elfinger, M.; Pfeifer, C.; Uezguen, S.; Golas, M. M.; Sander, B.; Mauksch, C.; Stark, H.; Aneja, M. K.; Rudolph, C.: Self-assembly of ternary insulin−polyethylenimine (PEI)−DNA nanoparticles for enhanced gene delivery and expression in alveolar epithelial cells. Biomacromolecules 10 (10), S. 2912 - 2920 (2009)
  54. Zeitschriftenartikel
    Wolf, E.; Kastner, B.; Deckert, J.; Merz, C.; Stark, H.; Lührmann, R.: Exon, intron and splice site locations in the spliceosomal B complex. EMBO Journal 28, S. 2283 - 2292 (2009)
  55. Zeitschriftenartikel
    Andersen, E. S.; Dong, M.; Nielsen, M. M.; Jahn, K.; Subramani, R.; Mamdouh, W.; Golas, M. M.; Sander, B.; Stark, H.; Oliveira, C. L. et al.; Pedersen, J. S.; Birkedal, V.; Besenbacher, F.; Gothelf, K. V.; Kjems, J.: Self-assembly of a nanoscale DNA box with a controllable lid. Nature 459 (7243), S. 73 - 76 (2009)
  56. Zeitschriftenartikel
    Golas, M. M.; Boehm, C.; Sander, B.; Effenberger, K.; Brecht, M.; Stark, H.; Goeringer, H. U.: Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo. EMBO Journal 28 (6), S. 766 - 778 (2009)
  57. Zeitschriftenartikel
    Herzog, F.; Primorac, I.; Dube, P.; Lenart, P.; Sander, B.; Mechtler, K.; Stark, H.; Peters, J. M.: Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science 323 (5920), S. 1477 - 1481 (2009)
  58. Zeitschriftenartikel
    Fabrizio, P.; Dannenberg, J.; Dube, P.; Kastner, B.; Stark, H.; Urlaub, H.; Lührmann, R.: The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Molecular Cell 36 (4), S. 593 - 608 (2009)
  59. Zeitschriftenartikel
    Lührmann, R.; Stark, H.: Structural mapping of spliceosomes by electron microscopy. Current Opinion in Structural Biology 19, S. 96 - 102 (2009)
  60. Zeitschriftenartikel
    Sanchez, M.; Drechsler, M.; Stark, H.; Lipps, G.: DNA translocation activity of the multifunctional replication protein ORF904 from the archaeal plasmid pRN1. Nucleic Acids Research 37 (20), S. 6831 - 6848 (2009)
  61. Zeitschriftenartikel
    Schmeisser, M.; Heisen, B.; Luettich, M.; Busche, B.; Hauer, F.; Koske, T.; Knauber, K. H.: Parallel, distributed and GPU computing technologies in single-particle electron microscopy. Acta Crystallographica D 65 (7), S. 659 - 671 (2009)
  62. Zeitschriftenartikel
    Karaduman, R.; Dube, P.; Stark, H.; Fabrizio, P.; Kastner, B.; Luehrmann, R.: Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy. RNA 14, S. 2528 - 2537 (2008)
  63. Zeitschriftenartikel
    Haecker, I.; Sander, B.; Golas, M. M.; Wolf, E.; Karagoez, E.; Kastner, B.; Stark, H.; Fabrizio, P.; Luehrmann, R.: Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nature Structural and Molecular Biology 15 (11), S. 1206 - 1212 (2008)
  64. Zeitschriftenartikel
    Chari, A.; Golas, M. M.; Klingenhaeger, M.; Neuenkirchen, N.; Sander, B.; Englbrecht, C.; Sickmann, A.; Stark, H.; Fischer, U.: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Cell 135 (3), S. 497 - 509 (2008)
  65. Zeitschriftenartikel
    Kastner, B.; Fischer, N.; Golas, M. M.; Sander, B.; Dube, P.; Boehringer, D.; Hartmuth, K.; Deckert, J.; Hauer, F.; Wolf, E. et al.; Uchtenhagen, H.; Urlaub, H.; Herzog, F.; Peters, J. M.; Porschke, D.; Luehrmann, R.; Stark, H.: GraFix: sample preparation for single-particle electron cryomicroscopy. Nature Methods 5 (1), S. 53 - 55 (2008)
  66. Zeitschriftenartikel
    Sirajuddin, M.; Farkasovsky, M.; Hauer, F.; Kuehlmann, D.; Macara, I. G.; Weyand, M.; Stark, H.; Wittinghofer, A.: Structural insight into filament formation by mammalian septins. Nature 449 (7160), S. 311 - 315 (2007)
  67. Zeitschriftenartikel
    Kuehn-Hoelsken, E.; Dybkov, O.; Sander, B.; Luehrmann, R.; Urlaub, H.: Improved identification of enriched peptide–RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry. Nucleic Acids Research 35 (15), e95 (2007)
  68. Zeitschriftenartikel
    Behzadnia, N.; Golas, M. M.; Hartmuth, K.; Sander, B.; Kastner, B.; Deckert, J.; Dube, P.; Will, C. L.; Urlaub, H.; Stark, H. et al.; Luehrmann, R.: Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. The EMBO Journal 26 (6), S. 1737 - 1748 (2007)
  69. Zeitschriftenartikel
    Sander, B.; Golas, M. M.; Makarov, E. M.; Brahms, H.; Kastner, B.; Luehrmann, R.; Stark, H.: Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by Electron Cryomicroscopy. Molecular Cell 24 (2), S. 267 - 278 (2006)
  70. Zeitschriftenartikel
    Deckert, J.; Hartmuth, K.; Boehringer, D.; Behzadnia, N.; Will, C. L.; Kastner, B.; Stark, H.; Urlaub, H.; Luehrmann, R.: Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Molecular and Cellular Biology 26 (14), S. 5528 - 5543 (2006)
  71. Zeitschriftenartikel
    Schellenberg, M. J.; Edwards, R. A.; Ritchie, D. B.; Kent, O. A.; Golas, M. M.; Stark, H.; Luehrmann, R.; Glover, J. N. M.; MacMilan, A. M.: Crystal structure of a core spliceosomal protein interface. Proceedings of the National Academy of Sciences of the United States of America 103 (5), S. 1266 - 1271 (2006)
  72. Zeitschriftenartikel
    Stark, H.; Luehrmann, R.: Cryo-electron microscopy of spliceosomal components. Annual Review of Biophysics and Biomolecular Structure 35, S. 435 - 457 (2006)
  73. Zeitschriftenartikel
    Kuehn-Hoelsken, E.; Lenz, C.; Sander, B.; Luehrmann, R.; Urlaub, H.: Complete MALDI-ToF MS analysis of cross-linked peptide-RNA oligonucleotides derived from nonlabeled UV-irradiated ribonucleoprotein particles. RNA 11 (12), S. 1915 - 1930 (2005)
  74. Zeitschriftenartikel
    Golas, M. M.; Sander, B.; Will, C. L.; Luehrmann, R.; Stark, H.: Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy. Molecular Cell 17 (6), S. 869 - 883 (2005)
  75. Zeitschriftenartikel
    Boehringer, D.; Thermann, R.; Ostareck-Lederer, A.; Lewis, J. D.; Stark, H.: Structure of the hepatitis C virus IRES bound to the human 80S ribosome: Remodeling of the HCV IRES. Structure 13, S. 1695 - 1706 (2005)
  76. Zeitschriftenartikel
    Diaconu, M.; Kothe, U.; Schluenzen, F.; Fischer, N.; Harms, J.; Tonevitsky, A. G.; Stark, H.; Rodnina, M. V.; Wahl, M. C.: Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation. Cell 121, S. 991 - 1004 (2005)
  77. Zeitschriftenartikel
    Dube, P.; Herzog, F.; Gieffers, C.; Sander, B.; Riedel, D.; Mueller, S.; Engel, A.; Peters, J. M.; Stark, H.: Localization of the Coactivator Cdh1 and the Cullin Subunit Apc2 in a Cryo-Electron Microscopy Model of Vertebrate APC/C. Molecular Cell 20, S. 867 - 879 (2005)
  78. Zeitschriftenartikel
    Rudolph, C.; Schillinger, U.; Ortiz, A.; Plank, C.; Golas, M. M.; Sander, B.; Stark, H.; Rosenecker, J.: Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium. Molecular Therapy 12, S. 493 - 501 (2005)
  79. Zeitschriftenartikel
    Sander, B.; Golas, M. M.; Stark, H.: Advantages of CCD detectors for de novo three-dimensional structure determination in single-particle electron microscopy. Journal of Structural Biology 151, S. 92 - 105 (2005)
  80. Zeitschriftenartikel
    Tichelaar, W.; Safferling, M.; Keinanen, K.; Stark, H.; Madden, D. R.: The three-dimensional structure of an ionotropic glutamate receptor reveals a dimer-of-dimers assembly. Journal of Molecular Biology 344 (2), S. 435 - 442 (2004)
  81. Zeitschriftenartikel
    Boehringer, D.; Makarov, E. M.; Sander, B.; Makarova, O.; Kastner, B.; Luehrmann, R.; Stark, H.: Three-dimensional structure of a pre-catalytic human spliceosomal complex B. Nature Structural and Molecular Biology 11 (5), S. 463 - 468 (2004)
  82. Zeitschriftenartikel
    Stark, H.: Elektronenmikroskopische 3D-Strukturbestimmung makromolekularer Komplexe. BIOspektrum 5, S. 636 - 638 (2004)
  83. Zeitschriftenartikel
    Sander, B.; Golas, M. M.; Stark, H.: Corrim-based alignment for improved speed in single-particle image processing. Journal of Structural Biology 143 (3), S. 219 - 228 (2003)
  84. Zeitschriftenartikel
    Sander, B.; Golas, M. M.; Stark, H.: Automatic CTF correction for single particles based upon multivariate statistical analysis of individual power spectra. Journal of Structural Biology 142 (3), S. 392 - 401 (2003)
  85. Zeitschriftenartikel
    Meissner, U.; Stohr, M.; Kusche, K.; Burmester, T.; Stark, H.; Harris, J. R.; Orlova, E. V.; Markl, J.: Quaternary structure of the European spiny lobster (Palinurus elephas) 1 x 6-mer hemocyanin from cryoEM and amino acid sequence data. Journal of Molecular Biology 325 (1), S. 99 - 109 (2003)
  86. Zeitschriftenartikel
    Golas, M. M.; Sander, B.; Will, C. L.; Luehrmann, R.; Stark, H.: Molecular architecture of the multiprotein splicing factor SF3b. Science 300, S. 980 - 984 (2003)
  87. Zeitschriftenartikel
    Stark, H.; Rodnina, M. V.; Wieden, H. J.; Zemlin, F.; Wintermeyer, W.; van Heel, M.: Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex. Nature Structural Biology 9 (11), S. 849 - 854 (2002)
  88. Zeitschriftenartikel
    Gieffers, C.; Dube, P.; Harris, J. R.; Stark, H.; Peters, J. M.: Three-dimensional structure of the anaphase-promoting complex. Molecular Cell 7, S. 907 - 913 (2001)
  89. Zeitschriftenartikel
    Maurer, N.; Wong, K. F.; Stark, H.; Louie, L.; McIntosh, D.; Wong, T.; Scherrer, P.; Semple, S. C.; Cullis, P. R.: Spontaneous Entrapment of Polynucleotides upon Electrostatic Interaction with Ethanol-Destabilized Cationic Liposomes. Biophysical Journal 80, S. 2310 - 2326 (2001)
  90. Zeitschriftenartikel
    Semple, S. C.; Klimuk, S. K.; Harasym, T. O.; Dos Santos, N.; Ansell, S. M.; Wong, K. F.; Maurer, N.; Stark, H.; Cullis, P. R.; Hope, M. J. et al.; Scherrer, P.: Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures. Biochimica et Biophysica Acta 1510, S. 152 - 166 (2001)
  91. Zeitschriftenartikel
    Stark, H.; Dube, P.; Luehrmann, R.; Kastner, B.: Arrangement of RNA and Proteins in the spliceosomal U1 snRNP. Nature 409, S. 539 - 542 (2001)
  92. Zeitschriftenartikel
    Stark, H.; Dube, P.; Luehrmann, R.; Kastner, B.: The 3-D arrangement for RNA and Proteins in the spliceosomal U1 snRNP. Nature 409, S. 539 - 542 (2001)
  93. Zeitschriftenartikel
    Stewart, L.; Manvell, M.; Hilery, E.; Etheridge, C. J.; Cooper, R. G.; Stark, H.; van Heel, M.; Preuss, M.; Alton, E.; Miller, A.: Physico-chemical analysis of cationic liposome-DNA complexes (lipoplexes) with respect to in vitro and in vivo gene delivery efficiency. Journal of Chemical Society 2, S. 624 - 632 (2001)
  94. Zeitschriftenartikel
    Meissner, U.; Dube, P.; Harris, J. R.; Stark, H.; Markl, J.: Structure of a molluscan hemocyanin didecamer (HtH 1 from Haliotis tuberculata) at 12 A resolution by cryoelectron microscopy. Journal of Molecular Biology 298, S. 21 - 34 (2000)
  95. Zeitschriftenartikel
    Tam, P.; Monck, M.; Lee, D.; Ludkovski, O.; Leng, E. C.; Clow, K.; Stark, H.; Scherrer, P.; Graham, R. W.; Cullis, P. R.: Stabilized plasmid-lipid particles for systemic gene therapy. Gene Therapy 7, S. 1867 - 1874 (2000)
  96. Zeitschriftenartikel
    van Heel, M.; Gowen, B.; Matadeen, R.; Orlova, E. V.; Finn, R.; Pape, T.; Cohen, D.; Stark, H.; Schmidt, R.; Schatz, M. et al.; Patwardhan, A.: Single-particle electron cryo-micrsocopy: towards atomic resolution. Quarterly Reviews of Biophysics 33, S. 307 - 369 (2000)
  97. Zeitschriftenartikel
    Harding, L. B.; Stark, H.; Troe, J.; Ushakov, V. G.: New studies of the unimolecular reaction NO2  O + No. II. Relation between high pressure rate constants and potential parameters. Physical Chemistry Chemical Physics 1, S. 63 - 72 (1999)
  98. Zeitschriftenartikel
    Harms, J.; Tocilj, A.; Levin, I.; Agmon, I.; Stark, H.; Kolln, I.; van Heel, M.; Cuff, M.; Schluenzen, F.; Bashan, A. et al.; Franceschi, F.; Yonath, A.: Elucidating the medium-resolution structure of ribosomal particles: an interplay between electron cryo-microscopy and x-ray crystallography. Structure Folding and Design 7, S. 931 - 941 (1999)
  99. Zeitschriftenartikel
    Hippler, H.; Siefke, M.; Stark, H.; Troe, J.: New studies of the unimolecular reaction NO2  O + No. I. High pressure range of the O + NO recombination between 200 and 400 K. Physical Chemistry - Chemical Physics 1, S. 57 - 61 (1999)
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