Publikationen
Zeitschriftenartikel (236)
1.
Zeitschriftenartikel
Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity. Frontiers in Aging Neuroscience 13, 635760 (2021)
2.
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Special issue: Multicomponent lipid membranes—how molecular organisation leads to function. European Biophysics Journal 50 (2), S. 107 - 108 (2021)
3.
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Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis. Cellular and Molecular Life Sciences 78 (5), S. 2355 - 2370 (2021)
4.
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Structure, gating and interactions of the voltage-dependent anion channel. European Biophysics Journal 50 (2), S. 159 - 172 (2021)
5.
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Membrane-embedded TSPO: an NMR view. European Biophysics Journal 50 (2), S. 173 - 180 (2021)
6.
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A novel SNCA A30G mutation causes familial Parkinsonʼs disease. Movement Disorders, In Press (2021)
7.
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Structural Flexibility of Cyclosporine A Is Mediated by Amide Cis–Trans Isomerization and the Chameleonic Roles of Calcium. Journal of Physical Chemistry B 125 (5), S. 1378 - 1391 (2021)
8.
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Interplay between tau and α‐synuclein liquid–liquid phase separation. Protein Science, In Press (2021)
9.
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Disease‐associated tau phosphorylation hinders tubulin assembly within tau condensates. Angewandte Chemie International Edition 60 (2), S. 726 - 730 (2021)
10.
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Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils. Scientific Reports 10, 21210 (2020)
11.
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Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop. Protein Science 29 (12), S. 2422 - 2432 (2020)
12.
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Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war. Nature Communications 11, 6046 (2020)
13.
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Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates. Nature Communications 11, 6041 (2020)
14.
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Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. Scientific Reports 10, 12827 (2020)
15.
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Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 6 (30), eaba3916 (2020)
16.
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A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol. Nature Communications 11, 2729 (2020)
17.
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Determination of complex small molecule structures using molecular alignment simulation. Angewandte Chemie International Edition 59 (15), S. 6172 - 6176 (2020)
18.
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Molecular basis of the interaction of cyclophilin A with alpha-synuclein. Angewandte Chemie International Edition 132 (14), S. 5692 - 5695 (2020)
19.
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Biomolecular condensation of the microtubule-associated protein tau. Seminars in Cell and Developmental Biology 99, S. 202 - 214 (2020)
20.
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Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences of the United States of America 117 (6), S. 2948 - 2956 (2020)
21.
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Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. Biochimica et Biophysica Acta-Proteins and Proteomics 1868 (1), 140298 (2020)
22.
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Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nature Communications 10, 5535 (2019)
23.
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Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa. European Archives of Psychiatry and Clinical Neuroscience 269 (8), S. 973 - 984 (2019)
24.
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Towards a consensus on developmental regression. Neuroscience and Biobehavioral Reviews 107, S. 3 - 5 (2019)
25.
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Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. Acta Neuropathologica 138 (3), S. 415 - 441 (2019)
26.
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Dynamic Aha1 co-chaperone binding to human Hsp90. Protein Science 28 (9), S. 1545 - 1551 (2019)
27.
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Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau. Chemical Science 10 (26), S. 6503 - 6507 (2019)
28.
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Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature Communications 10 (1), 2909 (2019)
29.
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Reorientational dynamics of amyloid-β from NMR spin relaxation and molecular simulation. Journal of Physical Chemistry Letters 10, S. 3369 - 3375 (2019)
30.
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In response to: The validity of 18F-GE180 as a TSPO imaging agent. European Journal of Nuclear Medicine and Molecular Imaging 46 (6), S. 1208 - 1211 (2019)
31.
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Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism. Journal of Neuroscience 39 (19), S. 3752 - 3769 (2019)
32.
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Structure and functions of microtubule associated proteins tau and MAP2c: Similarities and differences. Biomolecules 9 (3), 105 (2019)
33.
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Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-Protein in children with neurodevelopmental disorders. Neuroscience and Biobehavioral Reviews 98, S. 1 - 9 (2019)
34.
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Insights into cholesterol/membrane protein interactions using paramagnetic solid-state NMR. Chemistry - A European Journal 24 (66), S. 17606 - 17611 (2018)
35.
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Local and global dynamics in intrinsically disordered synuclein. Angewandte Chemie International Edition 57 (46), S. 15262 - 15266 (2018)
36.
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Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 9, 4532 (2018)
37.
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Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: Binding ligands, affinity and structural features. Metallomics 10 (10), S. 1383 - 1389 (2018)
38.
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RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 25 (9), S. 833 - 840 (2018)
39.
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Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics. Journal of Biological Chemistry 293 (34), S. 13297 - 13309 (2018)
40.
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The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5. FEBS Journal 285 (11), S. 1988 - 2003 (2018)
41.
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Challenges and approaches to understand cholesterol-binding impact on membrane protein function: An NMR view. Cellular and Molecular Life Sciences 75 (12), S. 2137 - 2151 (2018)
42.
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The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease. Nanoscale 10 (19), S. 9174 - 9185 (2018)
43.
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Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural and Molecular Biology 25 (5), S. 384 - 393 (2018)
44.
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The binding mode of a repeat-like Tau sequence with tubulin. Angewandte Chemie International Edition 57 (12), S. 3246 - 3250 (2018)
45.
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Pathophysiological consequences of neuronal alpha-Synuclein overexpression: Impacts on ion homeostasis, stress signaling, mitochondrial integrity, and electrical activity. Frontiers in Molecular Neuroscience 11, 49 (2018)
46.
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Monitoring interactions inside cells by advanced spectroscopies: Overview of copper transporters and cisplatin. Current Medicinal Chemistry 25 (4), S. 462 - 477 (2018)
47.
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The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine 10 (1), S. 32 - 47 (2018)
48.
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Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature Communications 8, 1981 (2017)
49.
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Capture of dense core vesicles at synapses by JNK-dependent phosphorylation of Synaptotagmin-4. Cell Reports 21 (8), S. 2118 - 2133 (2017)
50.
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Small molecule-induced soluble oligomers of α-synuclein with helical structure. Chemistry. A European Journal 23 (53), S. 13010 - 13014 (2017)
51.
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Bioinorganic chemistry of Parkinson's disease: Affinity and structural features of Cu(I) binding to the full-length β-synuclein protein. Inorganic Chemistry 56 (17), S. 10387 - 10395 (2017)
52.
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Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature Communications 8, 275 (2017)
53.
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Reverse allostasis in biological systems: Minimal conditions and implications. Journal of Theoretical Biology 426, S. 134 - 139 (2017)
54.
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Human cyclophilin 40 unravels neurotoxic amyloids. PLoS Biology 15 (6), e2001336 (2017)
55.
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Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies. Brain 140 (5), S. 1399 - 1419 (2017)
56.
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Elucidating the structure of an infectious protein. PLoS Pathogens 13 (4), e1006229 (2017)
57.
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Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nature Structural and Molecular Biology 24 (4), S. 407 - 413 (2017)
58.
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The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biology 15 (3), e2000374 (2017)
59.
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Structure of monomeric transthyretin carrying the clinically important T119M mutation. Angewandte Chemie International Edition 55 (52), S. 16168 - 16171 (2016)
60.
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Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America 113 (42), S. E6506 - E6515 (2016)
61.
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Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of Amerca 113 (42), S. E6506 - E6515 (2016)
62.
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Voltage dependence of conformational dynamics and subconducting states of VDAC-1. Biophysical Journal 111 (6), S. 1223 - 1234 (2016)
63.
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High-resolution NMR determination of the dynamic structure of membrane proteins. Angewandte Chemie International Edition 55 (35), S. 101518 - 10521 (2016)
64.
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The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein. Protein Science 25 (8), S. 1563 - 1567 (2016)
65.
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Phosphorylation interferes with maturation of amyloid-β fibrillar structure in the N terminus. Journal of Biological Chemistry 291 (31), S. 16059 - 16067 (2016)
66.
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Solid-phase synthesis and characterization of N-terminally elongated A beta(-3-x)-peptides. Chemistry-A European Journal 22 (25), S. 8685 - 8693 (2016)
67.
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Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Science 25 (5), S. 1010 - 1020 (2016)
68.
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Fasudil attenuates aggregation of alpha-synuclein in models of Parkinson's disease. Acta Neuropathologica Communications 4, 39 (2016)
69.
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Phosphorylation modifies the molecular stability of beta-amyloid deposits. Nature Communications 7, 11359 (2016)
70.
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Molecular plasticity of the human Voltage-Dependent Anion Channel embedded into a membrane. Structure 24 (4), S. 585 - 594 (2016)
71.
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Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand. Biomolecular NMR Assignments 10 (1), S. 79 - 83 (2016)
72.
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Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity. Acta Neuropathologica 131 (4), S. 525 - 537 (2016)
73.
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Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Human Molecular Genetics 25 (2), S. 275 - 290 (2016)
74.
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Targeting intrinsically disordered proteins in rational drug discovery. Expert Opinion on Drug Discocery 11 (1), S. 65 - 77 (2016)
75.
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Retention and splicing complex (RES) - the importance of cooperativity. RNA Biology 13 (2), S. 128 - 133 (2016)
76.
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Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cell. Journal of Biological Chemistry 290 (46), S. 27582 - 27593 (2015)
77.
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Structural ensembles of intrinsically disordered proteins depend strongly on force field: A comparison to experiment. Journal of Chemical Theory and Computation 11 (11), S. 5513 - 5524 (2015)
78.
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Conformational flexibility in the transmembrane protein TSPO. Chemistry-A European Journal 21 (46), S. 16555 - 16563 (2015)
79.
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Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings. Journal of Biomolecular NMR 63 (3), S. 299 - 307 (2015)
80.
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Folding of the Tau protein on microtubules. Angewandte Chemie International Edition 54 (35), S. 10347 - 10351 (2015)
81.
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Structural impact of Tau phosphorylation at threonine 231. Structure 23 (8), S. 1448 - 1458 (2015)
82.
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Structure of the mammalian TSPO/PBR protein. Biochemical Society Transactions 43 (4), S. 566 - 571 (2015)
83.
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Structures of intermediates during RES complex assembly. Scientific Reports 5, 12545 (2015)
84.
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The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics 24 (14), S. 3971 - 3981 (2015)
85.
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Structural integrity of the A147T polymorph of mammalian TSPO. ChemBioChem 16 (10), S. 1483 - 1489 (2015)
86.
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Lost in translocation: The functions of the 18-kD translocator protein. Trends in Endocrinology and Metabolism 26 (7), S. 349 - 356 (2015)
87.
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Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proceedings of the National Academy of Sciences of the United States of America 112 (24), S. 7501 - 7506 (2015)
88.
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Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathologica 129 (5), S. 695 - 713 (2015)
89.
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HYCUD: A computational tool for prediction of effective rotational correlation time in flexible proteins. Bioinformatics 31 (8), S. 1319 - 1321 (2015)
90.
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Parkinson disease mutant E46K enhances alpha-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. Journal of Biological Chemistry 290 (15), S. 9412 - 9427 (2015)
91.
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Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2. Journal of Biomolecular NMR 61 (3-4), S. 311 - 320 (2015)
92.
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Multiple paramagnetic effects through a tagged reporter protein. Angewandte Chemie International Edition 54 (1), S. 336 - 339 (2015)
93.
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Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding. Journal of the American Chemical Society 137 (20), S. 6444 - 6447 (2015)
94.
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Small molecule-mediated stabilization of vesicle-associated helical alpha-synuclein inhibits pathogenic misfolding and aggregation. Nature Communications 5, 5857 (2014)
95.
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Interaction of the intermembrane space domain of Tim23 protein with mitochondrial membranes. Journal of Biological Chemistry 289 (50), S. 34620 - 34626 (2014)
96.
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Bioinorganic chemistry of synucleinopathies: Deciphering the binding features of Met motifs and His-50 in AS-Cu(I) interactions. Journal of Inorganic Biochemistry 141, S. 208 - 211 (2014)
97.
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A six-dimensional alpha proton detection-based APSY experiment for backbone assignment of intrinsically disordered proteins. Journal of Biomolecular NMR 60 (4), S. 231 - 240 (2014)
98.
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Long-range correlated dynamics in intrinsically disordered proteins. Journal of the American Chemical Society 136 (46), S. 16201 - 16209 (2014)
99.
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NMR-based detection of hydrogen/deuterium exchange in liposome-embedded membrane proteins. PLOS One 9 (11), e112374 (2014)