Publikationen

2.

Zeitschriftenartikel

Hamann, F.; Schmitt, A.; Favretto, F.; Hofele, R.; Neumann, P.; Xiang, S. Q.; Urlaub, H.; Zweckstetter, M.; Ficner, R.: Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences of the United States of America 117 (6), S. 2948 - 2956 (2020)

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3.

Zeitschriftenartikel

de Opakua, A. I.; Klama, F.; Ndukwe, I. E.; Martin, G. E.; Williamson, T. R.; Zweckstetter, M.: Determination of complex small molecule structures using molecular alignment simulation. Angewandte Chemie International Edition, (in press) (2020)

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4.

Zeitschriftenartikel

Masaracchia, C.; König, A.; Valiente-Gabioud, A. A.; Peralta, P.; Favretto, F.; Strohäker, T.; Lázaro, D. F.; Zweckstetter, M.; Fernandez, C. O.; Outeiro, T. F.: Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. Biochimica et Biophysica Acta-Proteins and Proteomics 1868 (1), 140298 (2020)

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5.

Zeitschriftenartikel

Favretto, F.; Baker, J.; Strohäker, T.; Andreas, L.; Blair, L.; Becker, S.; Zweckstetter, M.: Molecular basis of the interaction of cyclophilin A with alpha-synuclein. Angewandte Chemie International Edition, (in press) (2019)

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6.

Zeitschriftenartikel

Strohäker, T.; Jung, B. C.; Liou, S. H.; Fernandez, C. O.; Riedel, D.; Becker, S.; Halliday, G. M.; Bennati, M.; Kim, W. S.; Lee, S. J. et al.; Zweckstetter, M.: Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nature Communications 10, 5535 (2019)

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7.

Zeitschriftenartikel

Pellkofer, H.; Ihler, F.; Weiss, B. G.; Trothe, J.; Kadavath, H.; Chongtham, M.; Kunadt, M.; Riedel, D.; Lornsen, F.; Wilken, P. et al.; Bartels, C.; Hirschel, S.; Russo, S. G.; Stransky, E.; Trojan, L.; Schmidt, B.; Mandelkow, E.; Zweckstetter, M.; Canis, M.; Schneider, A.: Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa. European Archives of Psychiatry and Clinical Neuroscience 269 (8), S. 973 - 984 (2019)

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8.

Zeitschriftenartikel

Zhang, D.; Bedogni, F.; Boterberg, S.; Camfield, C.; Camfield, P.; Charman, T.; Curfs, L.; Einspieler, C.; Esposito, G.; De Filippis, B. et al.; Goin-Kochel, R. P.; Höglinger, G. U.; Holzinger, D.; Iosif, A. M.; Lancioni, G. E.; Landsberger, N.; Laviola, G.; Marco, E. M.; Müller, M.; Neul, J. L.; Nielsen-Saines, K.; Nordahl-Hansen, A.; O'Reilly, M. F.; Ozonoff, S.; Poustka, L.; Roeyers, h.; Rankovic, M.; Sigafoos, J.; Tammimies, K.; Townend, G. S.; Zwaigenbaum, L.; Zweckstetter, M.; Bölte, S.; Marschik, P. B.: Towards a consensus on developmental regression. Neuroscience and Biobehavioral Reviews 107, S. 3 - 5 (2019)

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9.

Zeitschriftenartikel

Rezaei-Ghaleh, N.; Munari, F.; Becker, S.; Assfalg, M.; Griesinger, C.: A facile oxygen-17 NMR method to determine effective viscosity in dilute, molecularly crowded and confined aqueous media. Chemical Communications 55 (82), S. 12404 - 12407 (2019)

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10.

Zeitschriftenartikel

Mavroeidi, P.; Arvanitaki, F.; Karakitsou, A. K.; Vetsi, M.; Kloukina, I.; Zweckstetter, M.; Giller, K.; Becker, S.; Sorrentino, Z. A.; Giasson, B. I. et al.; Jensen, P. H.; Stefanis, L.; Xilouri, M.: Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. Acta Neuropathologica 138 (3), S. 415 - 441 (2019)

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11.

Zeitschriftenartikel

Oroz, J.; Blair, L. J.; Zweckstetter, M.: Dynamic Aha1 co-chaperone binding to human Hsp90. Protein Science 28 (9), S. 1545 - 1551 (2019)

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12.

Zeitschriftenartikel

Ukmar-Godec, T.; Hutten, S.; Grieshop, M. P.; Rezaei-Ghaleh, N.; Cima-Omori, M. O.; Biernat, J.; Mandelkow, E.; Söding, J.; Dormann, D.; Zweckstetter, M.: Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature Communications 10 (1), 2909 (2019)

MPG.PuRe

13.

Zeitschriftenartikel

Ukmar-Godec, T.; Wegmann, S.; Zweckstetter, M.: Biomolecular condensation of the microtubule-associated protein tau. Seminars in Cell and Developmental Biology, (in press) (2019)

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14.

Zeitschriftenartikel

Rezaei-Ghaleh, N.; Parigi, G.; Zweckstetter, M.: Reorientational dynamics of amyloid-β from NMR spin relaxation and molecular simulation. Journal of Physical Chemistry Letters 10, S. 3369 - 3375 (2019)

MPG.PuRe

15.

Zeitschriftenartikel

Albert, N. L.; Unterrainer, M.; Brendel, M.; Kaiser, L.; Zweckstetter, M.; Cumming, P.; Bartenstein, P.: In response to: The validity of ¹⁸F-GE180 as a TSPO imaging agent. European Journal of Nuclear Medicine and Molecular Imaging 46 (6), S. 1208 - 1211 (2019)

MPG.PuRe

16.

Zeitschriftenartikel

Albert, N. L.; Unterrainer, M.; Brendel, M.; Kaiser, L.; Zweckstetter, M.; Cumming, P.; Bartenstein, P.: In response to: The validity of F-18-GE180 as a TSPO imaging agent. European Journal of Nuclear Medicine and Molecular Imaging 46 (6), S. 1208 - 1211 (2019)

MPG.PuRe

17.

Zeitschriftenartikel

Gong, J.; Szego, E. M.; Leonov, A.; Benito, E.; Becker, S.; Fischer, A.; Zweckstetter, M.; Outeiro, T.; Schneider, A.: Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism. Journal of Neuroscience 39 (19), S. 3752 - 3769 (2019)

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18.

Zeitschriftenartikel

Melková, K.; Zapletal, V.; Narasimhan, S.; Jansen, S.; Hritz, J.; Škrabana, R.; Zweckstetter, M.; Ringkjøbing-Jensen, M.; Blackledge, M.; Žídek, L.: Structure and functions of microtubule associated proteins tau and MAP2c: Similarities and differences. Biomolecules 9 (3), 105 (2019)

MPG.PuRe

19.

Zeitschriftenartikel

Gonzalez-Magana, A.; Ibanez de Opakua, A.; Romano-Moreno, M.; Murciano-Calles, J.; Merino, N.; Luque, I.; Rojas, A. L.; Onesti, S.; Blanco, F. J.; De Biasio, A.: The p12 subunit of human polymerase uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA). Journal of Biological Chemistry 294 (11), S. 3947 - 3956 (2019)

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20.

Zeitschriftenartikel

Rankovic, M.; Zweckstetter, M.: Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-Protein in children with neurodevelopmental disorders. Neuroscience and Biobehavioral Reviews 98, S. 1 - 9 (2019)

MPG.PuRe

21.

Zeitschriftenartikel

Jaipuria, G.; Giller, K.; Leonov, A.; Becker, S.; Zweckstetter, M.: Insights into cholesterol/membrane protein interactions using paramagnetic solid-state NMR. Chemistry - A European Journal 24 (66), S. 17606 - 17611 (2018)

MPG.PuRe

22.

Zeitschriftenartikel

Rezaei-Ghaleh, N.; Parigi, G.; Soranno, A.; Holla, A.; Becker, S.; Schuler, B.; Luchinat, C.; Zweckstetter, M.: Local and global dynamics in intrinsically disordered synuclein. Angewandte Chemie International Edition 57 (46), S. 15262 - 15266 (2018)

MPG.PuRe

23.

Zeitschriftenartikel

Oroz, J.; Chang, B. J.; Wysoczanski, P.; Lee, C. T.; Perez-Lara, A.; Chakraborty, P.; Hofele, R. V.; Baker, J. D.; Blair, L. J.; Biernat, J. et al.; Urlaub, H.; Mandelkow, E.; Dickey, C. A.; Zweckstetter, M.: Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 9, 4532 (2018)

MPG.PuRe

24.

Zeitschriftenartikel

Gentile, I.; Garro, H. A.; Delgado Ocaña, S.; Gonzalez, N.; Strohäker, T.; Schibich, D.; Quintanar, L.; Sambrotta, L.; Zweckstetter, M.; Griesinger, C. et al.; Menacho Márqueza, M.; Fernandez, C. O.: Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: Binding ligands, affinity and structural features. Metallomics 10 (10), S. 1383 - 1389 (2018)

MPG.PuRe

25.

Zeitschriftenartikel

Jäckl, M.; Stollmaier, C.; Strohäker, T.; Hyz, K.; Maspero, E.; Polo, S.; Wiesner, S.: Beta-sheet augmentation is a conserved mechanism of priming HECT E3 ligases for ubiquitin ligation. Journal of Molecular Biology 430 (18), S. 3218 - 3233 (2018)

MPG.PuRe

26.

Zeitschriftenartikel

Böhning, M.; Dugast-Darzacq, C.; Rankovic, M.; Hansen, A. S.; Yu, T.; Marie-Nelly, H.; McSwiggen, D. T.; Kokic, G.; Dailey, G. M.; Cramer, P. et al.; Darzacq, X.; Zweckstetter, M.: RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 25 (9), S. 833 - 840 (2018)

MPG.PuRe

27.

Zeitschriftenartikel

Melkova, K.; Zapletal, V.; Jansen, S.; Nomilner, E.; Zachrdla, M.; Hritz, J.; Novacek, J.; Zweckstetter, M.; Jensen, M. R.; Blackledge, M. et al.; Zidek, L.: Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics. Journal of Biological Chemistry 293 (34), S. 13297 - 13309 (2018)

MPG.PuRe

28.

Zeitschriftenartikel

Abayev, M.; Rodrigues, J. P. G. L. M.; Srivastava, G.; Arshava, B.; Jaremko, L.; Jaremko, M.; Naider, F.; Levitt, M.; Anglister, J.: The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5. FEBS Journal 285 (11), S. 1988 - 2003 (2018)

MPG.PuRe

29.

Zeitschriftenartikel

Jaipuria, G.; Ukmar-Godec, T.; Zweckstetter, M.: Challenges and approaches to understand cholesterol-binding impact on membrane protein function: An NMR view. Cellular and Molecular Life Sciences 75 (12), S. 2137 - 2151 (2018)

MPG.PuRe

30.

Zeitschriftenartikel

Aliakbari, F.; Mohammad-Beigi, H.; Rezaei-Ghaleh, N.; Becker, S.; Esmatabad, F. D.; Seyedi, H. A. E.; Bardania, H.; Marvian, A. T.; Collingwood, J. F.; Christiansen, G. et al.; Zweckstetter, M.; Otzen, D. E.; Morshedi, D.: The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease. Nanoscale 10 (19), S. 9174 - 9185 (2018)

MPG.PuRe

31.

Zeitschriftenartikel

Mok, S. A.; Condello, C.; Freilich, R.; Gillies, A.; Arhar, T.; Oroz, J.; Kadavath, H.; Julien, O.; Assimon, V. A.; Rauch, J. N. et al.; Dunyak, B. M.; Lee, J.; Tsai, F. T. F.; Wilson, M. R.; Zweckstetter, M.; Dickey, C. A.; Gestwicki, J. E.: Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural and Molecular Biology 25 (5), S. 384 - 393 (2018)

MPG.PuRe

32.

Zeitschriftenartikel

Kadavath, H.; Cabrales-Fontela, Y.; Jaremko, M.; Jaremko, L.; Overkamp, K.; Biernat, J.; Mandelkow, E.; Zweckstetter, M.: The binding mode of a repeat-like Tau sequence with tubulin. Angewandte Chemie International Edition 57 (12), S. 3246 - 3250 (2018)

MPG.PuRe

33.

Zeitschriftenartikel

Tolö, J.; Taschenberger, G.; Leite, K.; Stahlberg, M. A.; Spehlbrink, G.; Kues, J.; Munari, F.; Capaldi, S.; Becker, S.; Zweckstetter, M. et al.; Dean, C.; Bähr, M.; Kügler, S.: Pathophysiological consequences of neuronal alpha-Synuclein overexpression: Impacts on ion homeostasis, stress signaling, mitochondrial integrity, and electrical activity. Frontiers in Molecular Neuroscience 11, 49 (2018)

MPG.PuRe

34.

Zeitschriftenartikel

Lasorsa, A.; Natile, G.; Rosato, A.; Tadini-Buoninsegni , F.; Arnesano , F.: Monitoring interactions inside cells by advanced spectroscopies: Overview of copper transporters and cisplatin. Current Medicinal Chemistry 25 (4), S. 462 - 477 (2018)

MPG.PuRe

35.

Zeitschriftenartikel

Martinez Hernandez, A.; Urbanke, H.; Gillman, A. L.; Lee, J.; Ryazanov, S.; Agbemenyah, H. Y.; Benito, E.; Jain, G.; Kaurani, L.; Grigorian, G. et al.; Leonov, A.; Rezaei-Ghaleh, N.; Wilken, P.; Arce, F. T.; Wagner, J.; Fuhrman, M.; Caruana, M.; Camilleri, A.; Vassallo, N.; Zweckstetter, M.; Benz, R.; Giese, A.; Schneider, A.; Korte, M.; Lal, R.; Griesinger, C.; Eichele, G.; Fischer, A.: The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine 10 (1), S. 32 - 47 (2018)

MPG.PuRe

36.

Zeitschriftenartikel

Cabrales-Fontela, Y.; Kadavath, H.; Biernat, J.; Riedel, D.; Mandelkow, E.; Zweckstetter, M.: Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature Communications 8, 1981 (2017)

MPG.PuRe

37.

Zeitschriftenartikel

Bharat, V.; Siebrecht, M.; Burk, K.; Ahmed, S.; Reissner, C.; Kohansal-Nodehi, M.; Steubler, V.; Zweckstetter, M.; Ting, J. T.; Dean, C.: Capture of dense core vesicles at synapses by JNK-dependent phosphorylation of Synaptotagmin-4. Cell Reports 21 (8), S. 2118 - 2133 (2017)

MPG.PuRe

38.

Zeitschriftenartikel

Fonseca-Ornelas, L.; Schmidt, C. D.; Camacho-Zarco, A. R.; Fernandez, C. O.; Becker, S.; Zweckstetter, M.: Small molecule-induced soluble oligomers of α-synuclein with helical structure. Chemistry. A European Journal 23 (53), S. 13010 - 13014 (2017)

MPG.PuRe

39.

Zeitschriftenartikel

Miotto, M. C.; Pavese, M. D.; Quintanar, L.; Zweckstetter, M.; Griesinger, C.; Fernández, C. O.: Bioinorganic chemistry of Parkinson's disease: Affinity and structural features of Cu(I) binding to the full-length β-synuclein protein. Inorganic Chemistry 56 (17), S. 10387 - 10395 (2017)

MPG.PuRe

40.

Zeitschriftenartikel

Ambadipudi, S.; Biernat, J.; Riedel, D.; Mandelkow, E.; Zweckstetter, M.: Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature Communications 8, 275 (2017)

MPG.PuRe

41.

Zeitschriftenartikel

Rezaei-Ghaleh, N.; Bakhtiari, D.; Rashidi, A.: Reverse allostasis in biological systems: Minimal conditions and implications. Journal of Theoretical Biology 426, S. 134 - 139 (2017)

MPG.PuRe

42.

Zeitschriftenartikel

Baker, J. D.; Shelton, L. B.; Zheng, D. L.; Favretto, F.; Nordhues, B. A.; Darling, A.; Sullivan, L. E.; Sun, Z. Y.; Solanki, P. K.; Martin, M. D. et al.; Suntharalingam, A.; Sabbagh, J. J.; Becker, S.; Mandelkow, E.; Uversky, V. N.; Zweckstetter, M.; Dickey, C. A.; Koren, J.; Blair, L. J.: Human cyclophilin 40 unravels neurotoxic amyloids. PLoS Biology 15 (6), e2001336 (2017)

MPG.PuRe

43.

Zeitschriftenartikel

Vincente Miranda, H.; Szego, E. M.; Oliveira, L. M.; Breda, C.; Darendelioglu, E.; de Oliveira, R. M.; Ferreira, D. G.; Gomes, M. A.; Rott, R.; Oliveira, M. et al.; Munari, F.; Enguita, F. J.; Simoes, T.; Rodrigues, E. F.; Heinrich, M.; Martins, I. C.; Zamolo, I.; Riess, O.; Cordeiro, C.; Ponces-Freire, A.; Lashuel, H. A.; Santos, N. C.; Lopes, L. V.; Xiang, W.; Jovin, T. M.; Penque, D.; Engelender, S.; Zweckstetter, M.; Klucken, J.; Giorgini, F.; Quintas, A.; Outeiro, T. F.: Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies. Brain 140 (5), S. 1399 - 1419 (2017)

MPG.PuRe

ZIP

44.

Zeitschriftenartikel

Zweckstetter, M.; Requena, J. R.; Wille, H.: Elucidating the structure of an infectious protein. PLoS Pathogens 13 (4), e1006229 (2017)

MPG.PuRe

45.

Zeitschriftenartikel

Oroz, J.; Kim, J. H.; Chang, B. J.; Zweckstetter, M.: Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nature Structural and Molecular Biology 24 (4), S. 407 - 413 (2017)

MPG.PuRe

46.

Zeitschriftenartikel

de Oliveira, R. M.; Miranda, H. V.; Francelle, L.; Pinho, R.; Szegö, E. M.; Martinho, R.; Munari, F.; Lázaro, D. F.; Moniot, S.; Guerreiro, P. et al.; Fonseca, L.; Marijanovic, Z.; Antas, P.; Gerhardt, E.; Enguita, F. J.; Fauvet, B.; Penque, D.; Pais, T. F.; Tong, Q.; Becker, S.; Kügler, S.; Lashuel, H. A.; Steegborn, C.; Zweckstetter, M.; Outeiro, T. F.: The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biology 15 (3), e2000374 (2017)

MPG.PuRe

47.

Zeitschriftenartikel

Kim, J. H.; Oroz, J.; Zweckstetter, M.: Structure of monomeric transthyretin carrying the clinically important T119M mutation. Angewandte Chemie International Edition 55 (52), S. 16168 - 16171 (2016)

MPG.PuRe

48.

Zeitschriftenartikel

Marsh, D.: Nuclear spin-lattice relaxation in nitroxide spin-label EPR. Journal of Magnetic Resonance 272, S. 166 - 171 (2016)

MPG.PuRe

49.

Zeitschriftenartikel

Villar-Piquéa, A.; da Fonsecaa, T. L.; Sant’Annab, R.; Szegöa, E. M.; Fonseca-Ornelas, L.; Pinhoa, R.; Carijac, A.; Gerhardta, E.; Masaracchiaa, C.; Gonzalezf, E. A. et al.; Rossettif, G.; Carlonif, P.; Fernándezi, C. O.; Foguelb, D.; Milosevick, I.; Zweckstetter, M.; Venturac, S.; Outeiro, T. F.: Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America 113 (42), S. E6506 - E6515 (2016)

MPG.PuRe

50.

Zeitschriftenartikel

Villar-Piqué, A.; da Fonseca, T. L.; Sant’Anna, R.; Szegö, E. M.; Fonseca-Ornelas, L.; Pinho, R.; Carija, A.; Gerhardt, E.; Masaracchia, C.; Gonzalezf, E. A. et al.; Rossetti, G.; Carloni, P.; Fernández, C. O.; Foguel, D.; Milosevic, I.; Zweckstetter, M.; Ventura, S.; Outeiro, T. F.: Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of Amerca 113 (42), S. E6506 - E6515 (2016)

MPG.PuRe

51.

Zeitschriftenartikel

Briones, R.; Weichbrodt, C.; Paltrinieri, L.; Mey, I.; Villinger, S.; Giller, K.; Lange, A.; Zweckstetter, M.; Griesinger, C.; Becker, S. et al.; Steinem, C.; de Groot, B. L.: Voltage dependence of conformational dynamics and subconducting states of VDAC-1. Biophysical Journal 111 (6), S. 1223 - 1234 (2016)

MPG.PuRe

52.

Zeitschriftenartikel

Jaremko, M.; Jaremko, L.; Villinger, S.; Schmidt, C. D.; Griesinger, C.; Becker, S.; Zweckstetter, M.: High-resolution NMR determination of the dynamic structure of membrane proteins. Angewandte Chemie International Edition 55 (35), S. 101518 - 10521 (2016)

MPG.PuRe

53.

Zeitschriftenartikel

Fonseca-Ornelas, L.; Zweckstetter, M.: The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein. Protein Science 25 (8), S. 1563 - 1567 (2016)

MPG.PuRe

54.

Zeitschriftenartikel

Rezaei-Ghaleh, N.; Kumar, S.; Walter, J.; Zweckstetter, M.: Phosphorylation interferes with maturation of amyloid-β fibrillar structure in the N terminus. Journal of Biological Chemistry 291 (31), S. 16059 - 16067 (2016)

MPG.PuRe

55.

Zeitschriftenartikel

Beyer, I.; Rezaei-Ghaleh, N.; Klafki, H. W.; Jahn, O.; Haussmann, U.; Wiltfang, J.; Zweckstetter, M.; Knölker, H. J.: Solid-phase synthesis and characterization of N-terminally elongated A beta(-3-x)-peptides. Chemistry-A European Journal 22 (25), S. 8685 - 8693 (2016)

MPG.PuRe

56.

Zeitschriftenartikel

Akoury, E.; Mukrasch, M.; Biernat, J.; Tepper, K.; Ozenne, V.; Mandelkow, E.; Blackledge, M.; Zweckstetter, M.: Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Science 25 (5), S. 1010 - 1020 (2016)

MPG.PuRe

57.

Zeitschriftenartikel

Tatenhorst, L.; Eckermann, K.; Dambeck, V.; Fonseca-Ornelas, L.; Walle, H.; da Fonseca, T. L.; Koch, J. C.; Becker, S.; Toenges, L.; Bahr, M. et al.; Outeiro, T. F.; Zweckstetter, M.; Lingor, P.: Fasudil attenuates aggregation of alpha-synuclein in models of Parkinson's disease. Acta Neuropathologica Communications 4, 39 (2016)

MPG.PuRe

58.

Zeitschriftenartikel

Rezaei-Ghaleh, N.; Amininasab, M.; Kumar, S.; Walter , J.; Zweckstetter, M.: Phosphorylation modifies the molecular stability of beta-amyloid deposits. Nature Communications 7, 11359 (2016)

MPG.PuRe

59.

Zeitschriftenartikel

Ge, L.; Villinger, S.; Mari, S. A.; Giller, K.; Griesinger, C.; Becker, S.; Müller, D. J.; Zweckstetter, M.: Molecular plasticity of the human Voltage-Dependent Anion Channel embedded into a membrane. Structure 24 (4), S. 585 - 594 (2016)

MPG.PuRe

60.

Zeitschriftenartikel

Jaremko, M.; Jaremko, L.; Giller, K.; Becker, S.; Zweckstetter, M.: Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand. Biomolecular NMR Assignments 10 (1), S. 79 - 83 (2016)

MPG.PuRe

61.

Zeitschriftenartikel

Kumar, S.; Wirths, O.; Stüber, K.; Wunderlich, P.; Koch, P.; Theil, S.; Rezaei-Ghaleh, N.; Zweckstetter, M.; Bayer, T. A.; Bruestle, O. et al.; Thal, D. R.; Walter, J.: Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity. Acta Neuropathologica 131 (4), S. 525 - 537 (2016)

MPG.PuRe

62.

Zeitschriftenartikel

Tenreiro, S.; Rosado-Ramos, R.; Gerhardt, E.; Favretto, F.; Magalhães, F.; Popova, B.; Becker, S.; Zweckstetter, M.; Braus, G. H.; Outeiro, T. F.: Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Human Molecular Genetics 25 (2), S. 275 - 290 (2016)

MPG.PuRe

63.

Zeitschriftenartikel

Ambadipudi, S.; Zweckstetter, M.: Targeting intrinsically disordered proteins in rational drug discovery. Expert Opinion on Drug Discocery 11 (1), S. 65 - 77 (2016)

MPG.PuRe

64.

Zeitschriftenartikel

Wysoczanski, P.; Zweckstetter, M.: Retention and splicing complex (RES) - the importance of cooperativity. RNA Biology 13 (2), S. 128 - 133 (2016)

MPG.PuRe

65.

Zeitschriftenartikel

Moree, B.; Yin, G.; Lazaro, D. F.; Munari, F.; Strohäker, T.; Giller, K.; Becker, S.; Outeiro, T. F.; Zweckstetter, M.; Salafsky, J.: Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cell. Journal of Biological Chemistry 290 (46), S. 27582 - 27593 (2015)

MPG.PuRe

66.

Zeitschriftenartikel

Rauscher, S.; Gapsys, V.; Gajda, M. J.; Zweckstetter, M.; de Groot, B. L.; Grubmüller, H.: Structural ensembles of intrinsically disordered proteins depend strongly on force field: A comparison to experiment. Journal of Chemical Theory and Computation 11 (11), S. 5513 - 5524 (2015)

MPG.PuRe

67.

Zeitschriftenartikel

Jaremko, L.; Jaremko, M.; Giller, K.; Becker, S.; Zweckstetter, M.: Conformational flexibility in the transmembrane protein TSPO. Chemistry-A European Journal 21 (46), S. 16555 - 16563 (2015)

MPG.PuRe

68.

Zeitschriftenartikel

Gapsys, V.; Narayanan, R. L.; Xiang, S.; de Groot, B. L.; Zweckstetter, M.: Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings. Journal of Biomolecular NMR 63 (3), S. 299 - 307 (2015)

MPG.PuRe

69.

Zeitschriftenartikel

Kadavath, H.; Jaremko, M.; Jaremko, L.; Biernat, J.; Mandelkow, E.; Zweckstetter, M.: Folding of the Tau protein on microtubules. Angewandte Chemie International Edition 54 (35), S. 10347 - 10351 (2015)

MPG.PuRe

70.

Zeitschriftenartikel

Schwalbe, M.; Kadavath, H.; Biernat, J.; Ozenne, V.; Blackledge, M.; Mandelkow, E.; Zweckstetter, M.: Structural impact of Tau phosphorylation at threonine 231. Structure 23 (8), S. 1448 - 1458 (2015)

MPG.PuRe

71.

Zeitschriftenartikel

Jaremko, M.; Jaremko, L.; Jaipuria, G.; Becker, S.; Zweckstetter, M.: Structure of the mammalian TSPO/PBR protein. Biochemical Society Transactions 43 (4), S. 566 - 571 (2015)

MPG.PuRe

72.

Zeitschriftenartikel

Wysoczanski, P.; Becker, S.; Zweckstetter, M.: Structures of intermediates during RES complex assembly. Scientific Reports 5, 12545 (2015)

MPG.PuRe

73.

Zeitschriftenartikel

Fontaine, S. N.; Martin, M. D.; Akoury, E.; Assimon, V. A.; Borysov, S.; Nordhues, B. A.; Sabbagh, J. J.; Cockman, M.; Gestwicki, J. E.; Zweckstetter, M. et al.; Dickey, C. A.: The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics 24 (14), S. 3971 - 3981 (2015)

MPG.PuRe

74.

Zeitschriftenartikel

Jaremko, M.; Jaremko, L.; Giller, K.; Becker, S.; Zweckstetter, M.: Structural integrity of the A147T polymorph of mammalian TSPO. ChemBioChem 16 (10), S. 1483 - 1489 (2015)

MPG.PuRe

75.

Zeitschriftenartikel

Gut, P.; Zweckstetter, M.; Banati, R. B.: Lost in translocation: The functions of the 18-kD translocator protein. Trends in Endocrinology and Metabolism 26 (7), S. 349 - 356 (2015)

MPG.PuRe

76.

Zeitschriftenartikel

Kadavath, H.; Hofele, R. V.; Biernat, J.; Kumar, S.; Tepper, K.; Urlaub, H.; Mandelkow, E.; Zweckstetter, M.: Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proceedings of the National Academy of Sciences of the United States of America 112 (24), S. 7501 - 7506 (2015)

MPG.PuRe

77.

Zeitschriftenartikel

Kunadt, M.; Eckermann, K.; Stuendl, A.; Gong, J.; Russo, B.; Strauss, K.; Rai, S.; Kügler, S.; Falomir Lockhart, L. J.; Schwalbe, M. et al.; Krumova, P.; Oliveira, L. M. A.; Bähr, M.; Möbius, W.; Levin, J.; Giese, A.; Kruse, N.; Mollenhauer, B.; Geiss-Friedlander, R.; Ludolph, A. C.; Freischmidt, A.; Feiler, M. S.; Danzer, K. M.; Zweckstetter, M.; Jovin, T. M.; Simons, M.; Weishaupt, J. H.; Schneider, A.: Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathologica 129 (5), S. 695 - 713 (2015)

MPG.PuRe

78.

Zeitschriftenartikel

Rezaei-Ghaleh, N.; Klama, F.; Munari, F.; Zweckstetter, M.: HYCUD: A computational tool for prediction of effective rotational correlation time in flexible proteins. Bioinformatics 31 (8), S. 1319 - 1321 (2015)

MPG.PuRe

79.

Zeitschriftenartikel

Mbefo, M. K.; Fares, M. B.; Paleologou, K.; Oueslati, A.; Yin, G.; Tenreiro, S.; Pinto, M.; Outeiro, T.; Zweckstetter, M.; Masliah, E. et al.; Lashuel, H. A.: Parkinson disease mutant E46K enhances alpha-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. Journal of Biological Chemistry 290 (15), S. 9412 - 9427 (2015)

MPG.PuRe

80.

Zeitschriftenartikel

Gattin, Z.; Schneider, R.; Laukat, Y.; Giller, K.; Maier, E.; Zweckstetter, M.; Griesinger, C.; Benz, R.; Becker, S.; Lange, A.: Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2. Journal of Biomolecular NMR 61 (3-4), S. 311 - 320 (2015)

MPG.PuRe

81.

Zeitschriftenartikel

Camacho-Zarco, A. R.; Munari, F.; Wegstroth, M.; Liu, W. M.; Ubbink, M.; Becker, S.; Zweckstetter, M.: Multiple paramagnetic effects through a tagged reporter protein. Angewandte Chemie International Edition 54 (1), S. 336 - 339 (2015)

MPG.PuRe

82.

Zeitschriftenartikel

Miotto, M. C.; Valiente-Gabioud, A. A.; Rossetti, G.; Zweckstetter, M.; Carloni, P.; Selenko, P.; Griesinger, C.; Binolfi, A.; Fernández, C. O.: Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding. Journal of the American Chemical Society 137 (20), S. 6444 - 6447 (2015)

MPG.PuRe

83.

Zeitschriftenartikel

Fonseca-Ornelas, L.; Eisbach, S. E.; Paulat, M.; Giller, K.; Fernandez, C. O.; Outeiro, T. F.; Becker, S.; Zweckstetter, M.: Small molecule-mediated stabilization of vesicle-associated helical alpha-synuclein inhibits pathogenic misfolding and aggregation. Nature Communications 5, 5857 (2014)

MPG.PuRe

84.

Zeitschriftenartikel

Bajaj, R.; Munari, F.; Becker, S.; Zweckstetter, M.: Interaction of the intermembrane space domain of Tim23 protein with mitochondrial membranes. Journal of Biological Chemistry 289 (50), S. 34620 - 34626 (2014)

MPG.PuRe

85.

Zeitschriftenartikel

Miotto, M. C.; Binolfi, A.; Zweckstetter, M.; Griesinger, C.; Fernandez, C. O.: Bioinorganic chemistry of synucleinopathies: Deciphering the binding features of Met motifs and His-50 in AS-Cu(I) interactions. Journal of Inorganic Biochemistry 141, S. 208 - 211 (2014)

MPG.PuRe

86.

Zeitschriftenartikel

Yao, X.; Becker, S.; Zweckstetter, M.: A six-dimensional alpha proton detection-based APSY experiment for backbone assignment of intrinsically disordered proteins. Journal of Biomolecular NMR 60 (4), S. 231 - 240 (2014)

MPG.PuRe

87.

Zeitschriftenartikel

Parigi, G.; Rezaei-Ghaleh, N.; Giachetti, A.; Becker, S.; Fernandez, C.; Blackledge, M.; Griesinger, C.; Zweckstetter, M.; Luchinat, C.: Long-range correlated dynamics in intrinsically disordered proteins. Journal of the American Chemical Society 136 (46), S. 16201 - 16209 (2014)

MPG.PuRe

88.

Zeitschriftenartikel

Yao, X.; Dürr, U. H. N.; Gattin, Z.; Laukat, Y.; Narayanan, R.L.; Brückner, A. K.; Meisinger, C.; Lange, A.; Becker, S.; Zweckstetter, M.: NMR-based detection of hydrogen/deuterium exchange in liposome-embedded membrane proteins. PLOS One 9 (11), e112374 (2014)

MPG.PuRe

89.

Zeitschriftenartikel

Bajaj, R.; Jaremko, L.; Jaremko, M.; Becker, S.; Zweckstetter, M.: Molecular basis of the dynamic structure of the TIM23 complex in the mitochondrial intermembrane space. Structure 22 (10), S. 1501 - 1511 (2014)

MPG.PuRe

90.

Zeitschriftenartikel

Wysoczanski, P.; Schneider, C.; Xiang, S. Q.; Munari, F.; Trowitzsch, S.; Wahl, M. C.; Lührmann, R.; Becker, S.; Zweckstetter, M.: Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology 21 (10), S. 911 - 918 (2014)

MPG.PuRe

91.

Zeitschriftenartikel

Yin, G.; Lopes da Fonseca, T.; Eisbach, S. E.; Anduaga, A. M.; Breda, C.; Orcellet, M. L.; Szegő, E. M.; Guerreiro, P.; Lázaro, D. F.; Braus, G. H. et al.; Fernandez, C. O.; Griesinger, C.; Becker, S.; Goody, R. S.; Itzen, A.; Giorgini, F.; Outeiro, T. F.; Zweckstetter, M.: α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner. Neurobiology of Disease 70, S. 149 - 161 (2014)

MPG.PuRe

ZIP

92.

Zeitschriftenartikel

Jaremko, L.; Jaremko, M.; Becker, S.; Zweckstetter, M.: Toward the functional oligomerization state of tryptophan-rich sensory proteins. Protein Science 23 (8), S. 1154 - 1160 (2014)

MPG.PuRe

93.

Zeitschriftenartikel

Jensen, M. R.; Zweckstetter, M.; Huang, J.; Blackledge, M.: Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy. Chemical Reviews 114 (13), S. 6632 - 6660 (2014)

MPG.PuRe

94.

Zeitschriftenartikel

Xiang, S. Q.; Zweckstetter, M.: Detection of a transient intramolecular hydrogen bond using (l)J(NH) scalar couplings. Journal of Magnetic Resonance 243, S. 93 - 97 (2014)

MPG.PuRe

95.

Zeitschriftenartikel

Villinger, S.; Giller, K.; Bayrhuber, M.; Lange, A.; Griesinger, C.; Becker, S.; Zweckstetter, M.: Nucleotide interactions of the human voltage-dependent anion channel. Journal of Biological Chemistry 289 (19), S. 13397 - 13406 (2014)

MPG.PuRe

96.

Zeitschriftenartikel

Miotto, M. C.; Rodriguez, E. E.; Valiente-Gabioud, A. A.; Torres-Monserrat, V.; Binolfi, A.; Quintanar, L.; Zweckstetter, M.; Griesinger, C.; Fernandez, C. O.: Site-specific copper-catalyzed oxidation of alpha-synuclein: Tightening the link between metal binding and protein oxidative damage in Parkinson's disease. Inorganic Chemistry 53 (9), S. 4350 - 4358 (2014)

MPG.PuRe

97.

Zeitschriftenartikel

Munari, F.; Gajda, M. J.; Hiragami-Hamada, K.; Fischle, W.; Zweckstetter, M.: Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1 beta. FEBS Letters 588 (7), S. 1094 - 1099 (2014)

MPG.PuRe

98.

Zeitschriftenartikel

Rezaei-Ghaleh, N.; Amininasab, M.; Giller, K.; Kumar, S.; Stuendl, A.; Schneider, A.; Becker, S.; Walter, J.; Zweckstetter, M.: Turn plasticity distinguishes different modes of amyloid-beta aggregation. Journal of the American Chemical Society 136 (13), S. 4913 - 4919 (2014)

MPG.PuRe

99.

Zeitschriftenartikel

Jaremko, L.; Jaremko, M.; Giller, K.; Becker, S.; Zweckstetter, M.: Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science 343 (6177), S. 1363 - 1366 (2014)

MPG.PuRe