Publikationen
Zeitschriftenartikel (225)
1.
Zeitschriftenartikel
6 (30), eaba3916 (2020)
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 2.
Zeitschriftenartikel
132 (14), S. 5692 - 5695 (2020)
Molecular basis of the interaction of cyclophilin A with alpha-synuclein. Angewandte Chemie International Edition 3.
Zeitschriftenartikel
6 (8), eaaz1955 (2020)
Singlet-filtered NMR spectroscopy. Science Advances 4.
Zeitschriftenartikel
117 (6), S. 2948 - 2956 (2020)
Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences of the United States of America 5.
Zeitschriftenartikel
Determination of complex small molecule structures using molecular alignment simulation. Angewandte Chemie International Edition, (in press) (2020)
6.
Zeitschriftenartikel
1868 (1), 140298 (2020)
Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. Biochimica et Biophysica Acta-Proteins and Proteomics 7.
Zeitschriftenartikel
10, 5535 (2019)
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nature Communications 8.
Zeitschriftenartikel
269 (8), S. 973 - 984 (2019)
Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa. European Archives of Psychiatry and Clinical Neuroscience 9.
Zeitschriftenartikel
107, S. 3 - 5 (2019)
Towards a consensus on developmental regression. Neuroscience and Biobehavioral Reviews 10.
Zeitschriftenartikel
55 (82), S. 12404 - 12407 (2019)
A facile oxygen-17 NMR method to determine effective viscosity in dilute, molecularly crowded and confined aqueous media. Chemical Communications 11.
Zeitschriftenartikel
138 (3), S. 415 - 441 (2019)
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. Acta Neuropathologica 12.
Zeitschriftenartikel
28 (9), S. 1545 - 1551 (2019)
Dynamic Aha1 co-chaperone binding to human Hsp90. Protein Science 13.
Zeitschriftenartikel
10 (1), 2909 (2019)
Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature Communications 14.
Zeitschriftenartikel
Biomolecular condensation of the microtubule-associated protein tau. Seminars in Cell and Developmental Biology, (in press) (2019)
15.
Zeitschriftenartikel
10, S. 3369 - 3375 (2019)
Reorientational dynamics of amyloid-β from NMR spin relaxation and molecular simulation. Journal of Physical Chemistry Letters 16.
Zeitschriftenartikel
46 (6), S. 1208 - 1211 (2019)
In response to: The validity of 18F-GE180 as a TSPO imaging agent. European Journal of Nuclear Medicine and Molecular Imaging 17.
Zeitschriftenartikel
39 (19), S. 3752 - 3769 (2019)
Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism. Journal of Neuroscience 18.
Zeitschriftenartikel
9 (3), 105 (2019)
Structure and functions of microtubule associated proteins tau and MAP2c: Similarities and differences. Biomolecules 19.
Zeitschriftenartikel
294 (11), S. 3947 - 3956 (2019)
The p12 subunit of human polymerase uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA). Journal of Biological Chemistry 20.
Zeitschriftenartikel
98, S. 1 - 9 (2019)
Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-Protein in children with neurodevelopmental disorders. Neuroscience and Biobehavioral Reviews 21.
Zeitschriftenartikel
24 (66), S. 17606 - 17611 (2018)
Insights into cholesterol/membrane protein interactions using paramagnetic solid-state NMR. Chemistry - A European Journal 22.
Zeitschriftenartikel
57 (46), S. 15262 - 15266 (2018)
Local and global dynamics in intrinsically disordered synuclein. Angewandte Chemie International Edition 23.
Zeitschriftenartikel
9, 4532 (2018)
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 24.
Zeitschriftenartikel
10 (10), S. 1383 - 1389 (2018)
Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: Binding ligands, affinity and structural features. Metallomics 25.
Zeitschriftenartikel
430 (18), S. 3218 - 3233 (2018)
Beta-sheet augmentation is a conserved mechanism of priming HECT E3 ligases for ubiquitin ligation. Journal of Molecular Biology 26.
Zeitschriftenartikel
25 (9), S. 833 - 840 (2018)
RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 27.
Zeitschriftenartikel
293 (34), S. 13297 - 13309 (2018)
Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics. Journal of Biological Chemistry 28.
Zeitschriftenartikel
285 (11), S. 1988 - 2003 (2018)
The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5. FEBS Journal 29.
Zeitschriftenartikel
75 (12), S. 2137 - 2151 (2018)
Challenges and approaches to understand cholesterol-binding impact on membrane protein function: An NMR view. Cellular and Molecular Life Sciences 30.
Zeitschriftenartikel
10 (19), S. 9174 - 9185 (2018)
The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease. Nanoscale 31.
Zeitschriftenartikel
25 (5), S. 384 - 393 (2018)
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural and Molecular Biology 32.
Zeitschriftenartikel
57 (12), S. 3246 - 3250 (2018)
The binding mode of a repeat-like Tau sequence with tubulin. Angewandte Chemie International Edition 33.
Zeitschriftenartikel
11, 49 (2018)
Pathophysiological consequences of neuronal alpha-Synuclein overexpression: Impacts on ion homeostasis, stress signaling, mitochondrial integrity, and electrical activity. Frontiers in Molecular Neuroscience 34.
Zeitschriftenartikel
25 (4), S. 462 - 477 (2018)
Monitoring interactions inside cells by advanced spectroscopies: Overview of copper transporters and cisplatin. Current Medicinal Chemistry 35.
Zeitschriftenartikel
10 (1), S. 32 - 47 (2018)
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine 36.
Zeitschriftenartikel
8, 1981 (2017)
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature Communications 37.
Zeitschriftenartikel
21 (8), S. 2118 - 2133 (2017)
Capture of dense core vesicles at synapses by JNK-dependent phosphorylation of Synaptotagmin-4. Cell Reports 38.
Zeitschriftenartikel
23 (53), S. 13010 - 13014 (2017)
Small molecule-induced soluble oligomers of α-synuclein with helical structure. Chemistry. A European Journal 39.
Zeitschriftenartikel
56 (17), S. 10387 - 10395 (2017)
Bioinorganic chemistry of Parkinson's disease: Affinity and structural features of Cu(I) binding to the full-length β-synuclein protein. Inorganic Chemistry 40.
Zeitschriftenartikel
8, 275 (2017)
Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature Communications 41.
Zeitschriftenartikel
426, S. 134 - 139 (2017)
Reverse allostasis in biological systems: Minimal conditions and implications. Journal of Theoretical Biology 42.
Zeitschriftenartikel
15 (6), e2001336 (2017)
Human cyclophilin 40 unravels neurotoxic amyloids. PLoS Biology 43.
Zeitschriftenartikel
140 (5), S. 1399 - 1419 (2017)
Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies. Brain 44.
Zeitschriftenartikel
13 (4), e1006229 (2017)
Elucidating the structure of an infectious protein. PLoS Pathogens 45.
Zeitschriftenartikel
24 (4), S. 407 - 413 (2017)
Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nature Structural and Molecular Biology 46.
Zeitschriftenartikel
15 (3), e2000374 (2017)
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biology 47.
Zeitschriftenartikel
55 (52), S. 16168 - 16171 (2016)
Structure of monomeric transthyretin carrying the clinically important T119M mutation. Angewandte Chemie International Edition 48.
Zeitschriftenartikel
272, S. 166 - 171 (2016)
Nuclear spin-lattice relaxation in nitroxide spin-label EPR. Journal of Magnetic Resonance 49.
Zeitschriftenartikel
113 (42), S. E6506 - E6515 (2016)
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America 50.
Zeitschriftenartikel
113 (42), S. E6506 - E6515 (2016)
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of Amerca 51.
Zeitschriftenartikel
111 (6), S. 1223 - 1234 (2016)
Voltage dependence of conformational dynamics and subconducting states of VDAC-1. Biophysical Journal 52.
Zeitschriftenartikel
55 (35), S. 101518 - 10521 (2016)
High-resolution NMR determination of the dynamic structure of membrane proteins. Angewandte Chemie International Edition 53.
Zeitschriftenartikel
25 (8), S. 1563 - 1567 (2016)
The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein. Protein Science 54.
Zeitschriftenartikel
291 (31), S. 16059 - 16067 (2016)
Phosphorylation interferes with maturation of amyloid-β fibrillar structure in the N terminus. Journal of Biological Chemistry 55.
Zeitschriftenartikel
22 (25), S. 8685 - 8693 (2016)
Solid-phase synthesis and characterization of N-terminally elongated A beta(-3-x)-peptides. Chemistry-A European Journal 56.
Zeitschriftenartikel
25 (5), S. 1010 - 1020 (2016)
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Science 57.
Zeitschriftenartikel
4, 39 (2016)
Fasudil attenuates aggregation of alpha-synuclein in models of Parkinson's disease. Acta Neuropathologica Communications 58.
Zeitschriftenartikel
7, 11359 (2016)
Phosphorylation modifies the molecular stability of beta-amyloid deposits. Nature Communications 59.
Zeitschriftenartikel
24 (4), S. 585 - 594 (2016)
Molecular plasticity of the human Voltage-Dependent Anion Channel embedded into a membrane. Structure 60.
Zeitschriftenartikel
10 (1), S. 79 - 83 (2016)
Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand. Biomolecular NMR Assignments 61.
Zeitschriftenartikel
131 (4), S. 525 - 537 (2016)
Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity. Acta Neuropathologica 62.
Zeitschriftenartikel
25 (2), S. 275 - 290 (2016)
Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Human Molecular Genetics 63.
Zeitschriftenartikel
11 (1), S. 65 - 77 (2016)
Targeting intrinsically disordered proteins in rational drug discovery. Expert Opinion on Drug Discocery 64.
Zeitschriftenartikel
13 (2), S. 128 - 133 (2016)
Retention and splicing complex (RES) - the importance of cooperativity. RNA Biology 65.
Zeitschriftenartikel
290 (46), S. 27582 - 27593 (2015)
Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cell. Journal of Biological Chemistry 66.
Zeitschriftenartikel
11 (11), S. 5513 - 5524 (2015)
Structural ensembles of intrinsically disordered proteins depend strongly on force field: A comparison to experiment. Journal of Chemical Theory and Computation 67.
Zeitschriftenartikel
21 (46), S. 16555 - 16563 (2015)
Conformational flexibility in the transmembrane protein TSPO. Chemistry-A European Journal 68.
Zeitschriftenartikel
63 (3), S. 299 - 307 (2015)
Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings. Journal of Biomolecular NMR 69.
Zeitschriftenartikel
54 (35), S. 10347 - 10351 (2015)
Folding of the Tau protein on microtubules. Angewandte Chemie International Edition 70.
Zeitschriftenartikel
23 (8), S. 1448 - 1458 (2015)
Structural impact of Tau phosphorylation at threonine 231. Structure 71.
Zeitschriftenartikel
43 (4), S. 566 - 571 (2015)
Structure of the mammalian TSPO/PBR protein. Biochemical Society Transactions 72.
Zeitschriftenartikel
5, 12545 (2015)
Structures of intermediates during RES complex assembly. Scientific Reports 73.
Zeitschriftenartikel
24 (14), S. 3971 - 3981 (2015)
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics 74.
Zeitschriftenartikel
16 (10), S. 1483 - 1489 (2015)
Structural integrity of the A147T polymorph of mammalian TSPO. ChemBioChem 75.
Zeitschriftenartikel
26 (7), S. 349 - 356 (2015)
Lost in translocation: The functions of the 18-kD translocator protein. Trends in Endocrinology and Metabolism 76.
Zeitschriftenartikel
112 (24), S. 7501 - 7506 (2015)
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proceedings of the National Academy of Sciences of the United States of America 77.
Zeitschriftenartikel
129 (5), S. 695 - 713 (2015)
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathologica 78.
Zeitschriftenartikel
31 (8), S. 1319 - 1321 (2015)
HYCUD: A computational tool for prediction of effective rotational correlation time in flexible proteins. Bioinformatics 79.
Zeitschriftenartikel
290 (15), S. 9412 - 9427 (2015)
Parkinson disease mutant E46K enhances alpha-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. Journal of Biological Chemistry 80.
Zeitschriftenartikel
61 (3-4), S. 311 - 320 (2015)
Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2. Journal of Biomolecular NMR 81.
Zeitschriftenartikel
54 (1), S. 336 - 339 (2015)
Multiple paramagnetic effects through a tagged reporter protein. Angewandte Chemie International Edition 82.
Zeitschriftenartikel
137 (20), S. 6444 - 6447 (2015)
Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding. Journal of the American Chemical Society 83.
Zeitschriftenartikel
5, 5857 (2014)
Small molecule-mediated stabilization of vesicle-associated helical alpha-synuclein inhibits pathogenic misfolding and aggregation. Nature Communications 84.
Zeitschriftenartikel
289 (50), S. 34620 - 34626 (2014)
Interaction of the intermembrane space domain of Tim23 protein with mitochondrial membranes. Journal of Biological Chemistry 85.
Zeitschriftenartikel
141, S. 208 - 211 (2014)
Bioinorganic chemistry of synucleinopathies: Deciphering the binding features of Met motifs and His-50 in AS-Cu(I) interactions. Journal of Inorganic Biochemistry 86.
Zeitschriftenartikel
60 (4), S. 231 - 240 (2014)
A six-dimensional alpha proton detection-based APSY experiment for backbone assignment of intrinsically disordered proteins. Journal of Biomolecular NMR 87.
Zeitschriftenartikel
136 (46), S. 16201 - 16209 (2014)
Long-range correlated dynamics in intrinsically disordered proteins. Journal of the American Chemical Society 88.
Zeitschriftenartikel
9 (11), e112374 (2014)
NMR-based detection of hydrogen/deuterium exchange in liposome-embedded membrane proteins. PLOS One 89.
Zeitschriftenartikel
22 (10), S. 1501 - 1511 (2014)
Molecular basis of the dynamic structure of the TIM23 complex in the mitochondrial intermembrane space. Structure 90.
Zeitschriftenartikel
21 (10), S. 911 - 918 (2014)
Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology 91.
Zeitschriftenartikel
70, S. 149 - 161 (2014)
α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner. Neurobiology of Disease 92.
Zeitschriftenartikel
23 (8), S. 1154 - 1160 (2014)
Toward the functional oligomerization state of tryptophan-rich sensory proteins. Protein Science 93.
Zeitschriftenartikel
114 (13), S. 6632 - 6660 (2014)
Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy. Chemical Reviews 94.
Zeitschriftenartikel
243, S. 93 - 97 (2014)
Detection of a transient intramolecular hydrogen bond using (l)J(NH) scalar couplings. Journal of Magnetic Resonance 95.
Zeitschriftenartikel
289 (19), S. 13397 - 13406 (2014)
Nucleotide interactions of the human voltage-dependent anion channel. Journal of Biological Chemistry 96.
Zeitschriftenartikel
53 (9), S. 4350 - 4358 (2014)
Site-specific copper-catalyzed oxidation of alpha-synuclein: Tightening the link between metal binding and protein oxidative damage in Parkinson's disease. Inorganic Chemistry 97.
Zeitschriftenartikel
588 (7), S. 1094 - 1099 (2014)
Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1 beta. FEBS Letters 98.
Zeitschriftenartikel
136 (13), S. 4913 - 4919 (2014)
Turn plasticity distinguishes different modes of amyloid-beta aggregation. Journal of the American Chemical Society 99.
Zeitschriftenartikel
343 (6177), S. 1363 - 1366 (2014)
Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science