Max Planck Institute for Biophysical Chemistry

Emerging Topics in Biomolecular Magnetic Resonance

Presenting frontier research in magnetic resonance in biological systems

Thursday, 10^th of December 2020

Structures of SARS-CoV-2 & Influenza Viroporins: a Quest to Block Pandemics

Mei Hong (MIT, Cambridge MA) more

Biomolecular condensation: from transcription to SARS-CoV-2

Markus Zweckstetter (DZNE/MPIBPC, Göttingen) more

Thursday, 3^rd of December 2020

Nanoparticle-assisted NMR spin relaxation: a new window into biomolecular interactions and dynamics

Rafael Brüschweiler (The Ohio State University)

Tracking the evolution of tau in solution, droplet and fibril states

Songi Han (UC Santa Barbara)

Thursday, 26^th of November 2020

Just flexible linkers? Un-structural biology by NMR

Roberta Pierattelli (University of Florence/CERM)

Factor X interaction with Ixolaris reveals a noncanonical mechanism of Kunitz inhibition

Ana Paula Valente (Federal University of Rio de Janeiro)

Thursday, 19^th of November 2020

ALIX in Wonderland: Multivalency and Phosphorylation-mediated Reversible Amyloids Studied by Solution NMR Spectroscopy

Lalit Deshmukh (University of California San Diego)

Lipid regulation of a K+ channel viewed by solid-state NMR

Benjamin J. Wylie (Texas Tech University)

Thursday, 12^th of November 2020

High-resulution NMR ob biomulecules, large and small, over orders of magnitude of magnetic fields

Fabien Ferrage (CNRS) more

Solid-state NMR approaches for cellular structural biology

Marc Baldus (Utrecht University) more

Thursday, 5^th of November 2020

Eavesdropping on the Cellular Adventures of a Pathogenic Cytotoxin

Jordan Chill (Bar Ilan University) more

Integrated Structural Biology of HIV-1 Assemblies

Tatyana Polenova (University of Delaware)

Thursday, 29^th of October 2020

Structure and function of biomolecules by detecting nuclear spins with EPR

Marina Bennati (Max Planck Institute for Biophysical Chemistry)

Mechanisms of Action for Pathogenic Mutations in the FGF Receptor Kinase

Nathaniel Traaseth (New York Frankfurt) more

Thursday, 22^nd of October 2020

Dynamic regulation of client and cochaperone interactions of Hsp90

Michael Sattler (Helmholtz Center & Technical University Munich)

Time-resolved solid state NMR of biomolecular self-assembly processes

Robert Tycko (NIDDK, National Institutes of Health) more

Thursday, 15^thof October 2020

Turning peptide toxins into therapeutics: the importance of structure AND dynamics

Raymond Norton (Monash University)

Protein (mis)folding at high sensitivity and resolution

Henrike Heise (Forschungszentrum Jülich) more

Thursday, 5^th of October 2020

Beyond static structures: Linking conformational changes in enzymes with function

Remco Sprangers (University of Regensburg) more

Innovations in Protein SSNMR using Ultra-fast MAS and SSNMR Studies on New Polymorphs of Ab42 Fibrils

Yoshitaka Ishii (Tokyo Institute of Technology & RIKEN)

Thursday, 1^st of October 2020

Interactions and dynamics of arginine side chains in proteins by ¹³C-detected NMR

Flemming D. Hansen (University College London) more

Structural architecture of yeast cell wall and functional amyloids by solid-state NMR

Antoine Loquet (Universite Bordeaux) more

Thursday, 24^th of September 2020

Finding order in disordered proteins

Robert Konrat (University of Vienna) more

The conformational equilibrium of the neuropeptide Y2 G protein-coupled receptor in membranes studied by solid-state NMR

Daniel Huster (Leipzig University) more

THURSDAY, 17^th of September 2020

Regulins control Ca²⁺-ATPase function via topological allostery

Gianluigi Veglia (University of Minnesota) more

Unveiling the “invisible” regulatory states in RNA

Qi Zhang (University of North Carolina at Chapel Hill)

THURSDAY, 10^th of September 2020

Proton detected experiments for structural characterization of biomolecules and a-synuclin fibril polymorphs from different aggregation intermediates

Vipin Agarwal (TIFR Hyderabad)

NMR-guided fragment-to-lead evolution

Ruan Ke (University of Science & Technology of China) more

THURSDAY, 3^rd of September 2020

Proton-detected solid-state NMR of viral protein assemblies

Anja Böckmann (University Lyon) more

New CEST Experiments to study protein conformational exchange

Pramodh Vallurupalli (Tata Institute of Fundamental Research) more

THURSDAY, 27^th of August 2020

NMR characterization of the structural E and S membrane proteins of SARS-CoV-2

Sang Ho Park (University of California, San Diego) more

NMR studies of SARS-CoV-2 viral RNAs, proteins and their complexes and screening against viral targets

Andreas Schlundt/Boris Fürtig (University Frankfurt) more

THURSDAY, 20^th of August 2020

Old wine in a new bottle: Repurposing 19F-NMR for biomolecules by combating the deleterious effects of CSA with TROSY

Haribabu Arthanari (Harvard Medical School) more

Resolving structure and functional dynamics of large protein complexes by solid-state NMR, cryo-EM and MD: from new methods to biological insight

Paul Schanda (Institut de Biologie Structurale, Grenoble) more

THURSDAY, 13^th of August 2020

Structural rearrangement modulates the regulatory activity in CCCH-type zinc finger proteins

Francesca Massi (University of Massachusetts) more

Heteronuclear spin decoupling for all (commerical) MAS frequencies: Methods and recipes

P. K. Madhu (TIFR Hyderabad) more

THURSDAY, 6^th of August 2020

The mystery of the double peak in the EPR spectrum of transferrin

Guinevere Mathies (University of Konstanz) more

High pressure NMR: Squeezing out unique information on protein ligand binding and conformational changes

Kevin Gardner (CUNY Advanced Science Research Center, New York) more

THURSDAY, 30^th of July 2020

MicroRNA dynamics by NMR: excited to see the invisible

Katja Petzold (Karolinska Institute) more

Novel nanodiscs for NMR studies on membrane proteins

Ayyalusamy Ramamoorthy (University of Michigan) more

THURSDAY, 23^rd of July 2020

High-resolution NMR of antibiotics in cell membranes

Markus Weingarth (Utrecht University) more

NMR of highly disordered molecular assemblies involved in viral replication

Martin Blackledge (Institut de Biologie Structurale Jean-Pierre Ebel, CEA, CNRS) more

THURSDAY, 16^th of July 2020

Solution NMR insights into phase separation of intrinsically disordered protein regions

Julie Forman-Kay (University of Toronto) more

MAS NMR studies of heterochromatin phase separation

Galia Debelouchina (University of California, San Diego)

THURSDAY, 9^th of July 2020

Spin state evolution during the biological water splitting reaction

Nick Cox (Australian National University) more

In cell structural biology enabled by DNP MAS NMR

Kendra Frederick (UT Southwestern) more

THURSDAY, 2^nd of July 2020

Structural equilibrium underlying ligand-dependent activation of GPCR

Ichio Shimada (RIKEN Center for Biosystems Dynamics Research)

A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR

Anne Grahl (Biozentrum, University of Basel) more

THURSDAY, 25^th of June 2020

Understanding extracellular matrix disease states with solid-state NMR?

Melinda J. Duer (University of Cambridge) more

NMR for metabolomics: again the 'second best' technique?

Claudio Luchinat (University of Florence) more

THURSDAY, 18^th of June 2020

Elucidation of carbohydrate structure in plant biomass and fungal pathogens using solid-state NMR and DNP methods

Tuo Wang (Lousiana State University) more

Molecular chaperones in protein disaggregation - What can we learn from NMR

Rina Rosenzweig (Weizmann Institute of Sciencey)

THURSDAY, 11^th of June 2020

Putative Amyloids in Human Health— Insights from NMR

Ann E. McDermott (Columbia University) more

An RNA dynamic ensemble at atomic resolution

Hashim Al-Hashimi (Duke University) more

THURSDAY, 4^th of June 2020

Mn(II) DEER tracks two ‘closed’ ATP-, ADP-dependent conformations in yeast Hsp90 chaperone

Daniella Goldfarb (Weizmann Institute of Science) more

NMR: The Big and the Invisible

Lewis Kay (University of Toronto) more