Horizons in Molecular Biology 2017: Proteomics Tracing the Footsteps of Viral Infection

Horizons in Molecular Biology 2017

  • Datum: 13.09.2017
  • Uhrzeit: 16:05 - 16:50
  • Vortragende(r): Ileana M. Cristea
  • Department of Molecular Biology, Princeton University
  • Ort: Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
  • Raum: Manfred Eigen Hall
  • Gastgeber: Horizons in Molecular Biology
  • Kontakt: participants.horizons@mpibpc.mpg.de
Plenary lecture of the 14th annual Horizons in Molecular Biology International PhD Symposium
Every year, a major cause of human disease and death worldwide is infection with the various viral pathogens that are intrinsic to our ecosystem. The outcomes of infections derive from the dynamic interactions between viruses and host cells that function to promote either virus replication or host defense against invading pathogens. Thus, viral infection triggers an impressive range of proteome changes. Alterations in protein abundances, interactions, posttranslational modifications, subcellular localizations, and secretion are temporally regulated during the progression of an infection. Consequently, recent years have highlighted mass spectrometry-based proteomics as a core component of fundamental discoveries in virology. This presentation will discuss proteomic methods developed for studying virus-host protein interactions, as well as alterations in proteome composition and organization in space and time during the progression of infection. We have applied such methods to addressing three main questions: 1) what host cell conditions allow infections to be permissive, 2) how the host immune system responds to the infection, and 3) what are the mechanisms of pathogen replication and transmission? Examples will be given from our studies of innate immune response upon infection with herpesviruses, as well as of mechanisms through which viruses remodel subcellular organelle function to suppress host defense and promote viral replication. Such studies demonstrate how integrative omic technologies can help paint a picture of the pathogen’s life cycle and aid in the future development of antiviral therapies.

Free registration at www.horizons.uni-goettingen.de
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