Fassberg Seminar: Regulation of gene expression in the three-dimensional genome

Fassberg Seminar

  • Date: Nov 19, 2019
  • Time: 11:00 - 12:00
  • Speaker: Marieke Oudelaar
  • University of Oxford
  • Location: Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
  • Room: Large Seminar Room / Administration Building
  • Host: Prof. Dr. Patrick Cramer
  • Contact: office.cramer@mpibpc.mpg.de
Fassberg Seminar: Regulation of gene expression in the three-dimensional genome
Precise gene expression patterns during mammalian development are controlled by cis-regulatory elements, including promoters, enhancers and boundary elements. These elements interact in specific three-dimensional structures in the interphase nucleus. However, it is not well understood how these structures are formed and how regulatory elements function within this context to control gene expression. I will present a combination of functional genomic and computational approaches that provide new insight into the origin and function of chromatin structures. Focussing on the well-characterised globin genes, I will discuss new techniques that have enabled in-depth analyses of their three-dimensional organisation and the function of regulatory elements within this configuration. In addition, I will present data showing how these specific chromatin structures are established during in vivo erythroid differentiation. I will also discuss how I plan to extend these observations genome-wide and in other model systems to further our understanding of the relationship between genome structure and function.
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