Fassberg Seminar: Heterochromatin organization and dynamics

Fassberg Seminar

  • Date: Jan 30, 2020
  • Time: 10:00 - 11:00
  • Speaker: Serena Sanulli
  • University of California, San Franciso (UCSF)
  • Location: Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
  • Room: Ludwig Prandtl Hall
  • Host: Marina Rodnina
  • Contact: helena.miletic@mpibpc.mpg.de
Fassberg Seminar: Heterochromatin organization and dynamics
DNA is wrapped around nucleosomes, forming chromatin chains that are further organized in three-dimensional assemblies. The architecture of these assemblies is crucial in determining cell transcriptional programs. Yet, the principles that underlie and regulate the architecture and organization of chromatin are poorly understood. I will present hydrogen-deuterium exchange, NMR, and mass-spectrometry data illustrating how HP1 proteins drive chromatin compaction into heterochromatin. I will propose a model for heterochromatin organization in which HP1 proteins couple chromatin compaction and phase separation by increasing the accessibility and dynamics of nucleosomes. I will further discuss the biophysical and biological implications of the proposed model in chromatin assemblies beyond heterochromatin.
Go to Editor View