Fassberg Seminar - ONLINE SEMINAR: Not all anti-tumor T cell responses are generated equal

Fassberg Seminar - ONLINE SEMINAR

  • Date: Mar 23, 2021
  • Time: 16:00 - 17:00
  • Speaker: Stefani Spranger
  • MIT, Cambridge, USA
  • Location: Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
  • Room: Zoom Online Seminar
  • Host: Marina Rodnina
  • Contact: gd.office@mpibpc.mpg.de
Fassberg Seminar - ONLINE SEMINAR: Not all anti-tumor T cell responses are generated equal
Cancer immunotherapies, first and foremost checkpoint blockade therapy (CBT), have revolutionized the treatment landscape of cancer patients, however, to date long-term clinical benefit is restricted to a minority of cancer patients. Responses to immunotherapy have been correlated to the presence of cytotoxic T cells within the tumor microenvironment and to the fact that these tumor-reactive killer cells have lost the functional ability to eliminate tumor cells. This terminal state of T cell differentiation is often referred to as T cell exhaustion and CBT agents can reinvigorate such exhausted T cell responses. More recently it has been appreciated that not all T cell responses follow this path of differentiation and are therefore resistant to reinvigoration by current CBT agents. We have generated mouse models which allow to study different types of T cell responses to cancer and focus particularly on the very early stages of T cell activation in the tumor-draining lymph node.
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