Fassberg Seminar - ONLINE SEMINAR: Not all anti-tumor T cell responses are generated equal
Fassberg Seminar - ONLINE SEMINAR
- Datum: 23.03.2021
- Uhrzeit: 16:00 - 17:00
- Vortragende(r): Stefani Spranger
- MIT, Cambridge, USA
- Ort: Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
- Raum: Zoom Online Seminar
- Gastgeber: Marina Rodnina
- Kontakt: gd.office@mpibpc.mpg.de
Cancer immunotherapies, first and foremost checkpoint blockade therapy (CBT), have revolutionized the treatment landscape of cancer patients, however, to date long-term clinical benefit is restricted to a minority of cancer patients. Responses to immunotherapy have been correlated to the presence of cytotoxic T cells within the tumor microenvironment and to the fact that these tumor-reactive killer cells have lost the functional ability to eliminate tumor cells. This terminal state of T cell differentiation is often referred to as T cell exhaustion and CBT agents can reinvigorate such exhausted T cell responses. More recently it has been appreciated that not all T cell responses follow this path of differentiation and are therefore resistant to reinvigoration by current CBT agents. We have generated mouse models which allow to study different types of T cell responses to cancer and focus particularly on the very early stages of T cell activation in the tumor-draining lymph node.