Mathematical bioPhysics

Mathematical bioPhysics

We develop and apply the methods of mathematical physics and the theory of stochastic processes to study phenomena in biophysics. Our main research focus is currently the non-equilibrium statistical mechanics of single molecules. In particular, we aim at a trajectory-based description of macromolecular conformation dynamics as well as of their spatial transport, binding, and reactions. In our work we employ a combination of rigorous analysis corroborated by computer simulations. For details please visit our research page.

Interested in joining us? Please see Open Positions for available positions.

Press Releases & Research News

Kristian Blom and Aljaž Godec at the MPI for Biophysical Chemistry successfully exploited the Ising model – which was originally used to describe ferromagnetism – to understand how the avidity of adhesion receptors and the strength of cellular adhesion can be regulated by mechanics.  more

Sufficiently small systems warm up faster than they cool down. Aljaz Godec and Allesio Lapolla have now mathematically proven this unforeseen asymmetry. They have shown that the counterplay of potential energy and entropy in the system, which warms up, is less of an obstacle on return to thermodynamic equilibrium.  more

Most recent papers

Blom, K.; Godec, A.:
Criticality in Cell Adhesion
Physical Review X 11, 031067 (2021)
Hartich, D.; Godec, A.: Thermodynamic uncertainty relation bounds the extent of anomalous diffusion. Physical Review Letters 127 (8), 080601 (2021)
Lapolla, A.; Vossel, M.; Godec, A.: Time- and ensemble-average statistical mechanics of the Gaussian network model. Journal of Physics A 54 (35), 355601 (2021)
Lapolla, A.; Godec, A.: BetheSF V2: 3-point propagator and additional external potentials. Computer Physics Communications 269, 108131 (2021)
Lapolla, A.; Godec, A.: BetheSF: Efficient computation of the exact tagged-particle propagator in single-file systems via the Bethe eigenspectrum. Computer Physics Communications 258, 107569 (2021)
Lapolla, A.; Godec, A.: Toolbox for quantifying memory in dynamics along reaction coordinates. Physical Review Research 3 (2), L022018 (2021)
Lapolla, A.; Godec, A.: Single-file diffusion in a bi-stable potential: Signatures of memory in the barrier-crossing of a tagged-particle. The Journal of Chemical Physics 153 (19), 194104 (2020)
Lapolla, A.; Hartich, D.; Godec, A.: Spectral theory of fluctuations in time-average statistical mechanics of reversible and driven systems. Physical Review Research 2 (4), 043084 (2020)
Lapolla, A.; Godec, A.: Faster uphill relaxation in thermodynamically equidistant temperature quenches. Physical Review Letters 125 (11), 110602 (2020)
Ukmar-Godec, T.; Fang, P.; Ibáñez de Opakua, A.; Henneberg, F.; Godec, A.; Pan, K. T.; Cima-Omori, M.-S.; Chari, A.; Mandelkow, E.; Urlaub, H. et al.; Zweckstetter, M.: Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 6 (30), eaba3916 (2020)

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