Publikationen von R. Lührmann

Zeitschriftenartikel (192)

21.
Zeitschriftenartikel
Bao, P.; Höbartner, C.; Hartmuth, K.; Lührmann, R.: Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing. RNA 23 (12), S. 1770 - 1779 (2017)
22.
Zeitschriftenartikel
Bao, P.; Will, C. L.; Urlaub, H.; Boon, K. L.; Lührmann, R.: The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development 31 (23-24), S. 2416 - 2429 (2017)
23.
Zeitschriftenartikel
Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), S. 701 - 713, e1 - e4 (2017)
24.
Zeitschriftenartikel
Fourmann, J. B.; Tauchert, M. J.; Ficner, R.; Fabrizio, P.; Lührmann, R.: Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2. Nucleic Acids Research 45 (7), S. 4068 - 4080 (2017)
25.
Zeitschriftenartikel
Sidarovich, A.; Will, C. L.; Anokhina, M. M.; Ceballos, J.; Sievers, S.; Agafonov, D. E.; Samatov, T.; Bao, P.; Kastner, B.; Urlaub, H. et al.; Waldmann, H.; Lührmann, R.: Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 6, e23533 (2017)
26.
Zeitschriftenartikel
Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), S. 318 - 323 (2017)
27.
Zeitschriftenartikel
Tauchert, M. J.; Fourmann, J. B.; Lührmann, R.; Ficner, R.: Structural insights into the mechanism of the DEAH-box RNA helicase Prp43. eLife 6, e21510 (2017)
28.
Zeitschriftenartikel
Pozzi, B.; Bragado, L.; Will, C. L.; Mammi, P.; Risso, G.; Urlaub, H.; Lührmann, R.; Srebrow, A.: SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 45 (11), S. 6729 - 6745 (2017)
29.
Zeitschriftenartikel
Cretu, C.; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De Laurentiis, E.; Sharma, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 64 (2), S. 307 - 319 (2016)
30.
Zeitschriftenartikel
Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), S. 1399 - 1405 (2016)
31.
Zeitschriftenartikel
Agafonov, D. E.; van Santen, M.; Kastner, B.; Dube, P.; Will, C. L.; Urlaub, H.; Lührmann, R.: ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 22 (9), S. 1329 - 1337 (2016)
32.
Zeitschriftenartikel
Sun, C.; Rigo, N.; Fabrizio, P.; Kastner, B.; Lührmann, R.: A protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA 22 (9), S. 1427 - 1440 (2016)
33.
Zeitschriftenartikel
Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Ficner, R.; Will, C. L.; Lührmann, R.: A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 7, 11997 (2016)
34.
Zeitschriftenartikel
Fourmann, J. B.; Dybkov, O.; Agafonov, D. E.; Tauchert, M. J.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 5, e15564 (2016)
35.
Zeitschriftenartikel
Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.; Urlaub, H.; Lührmann, R.; Stark, H.: Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), S. 1416 - 1420 (2016)
36.
Zeitschriftenartikel
Heininger, A. U.; Hackert, P.; Andreou, A. Z.; Boon, K. L.; Memet, I.; Prior, M.; Clancy, A.; Schmidt, B.; Urlaub, H.; Schleiff, E. et al.; Sloan, K. E.; Deckers, M.; Lührmann, R.; Enderlein, J.; Klostermeier, D.; Rehling, P.; Bohnsack, M. T.: Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology 13 (3), S. 320 - 330 (2016)
37.
Zeitschriftenartikel
Schütze, T.; Ulrich, A. K. C.; Apelt, L.; Will, C. L.; Bartlick, N.; Seeger, M.; Weber, G.; Lührmann, R.; Stelzl, U.; Wahl, M. C.: Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 22 (2), S. 265 - 277 (2016)
38.
Zeitschriftenartikel
Tauchert, M. J.; Fourmann, J. B.; Christian, H.; Lührmann, R.; Ficner, R.: Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 72 (2), S. 112 - 120 (2016)
39.
Zeitschriftenartikel
Jagtap, P. K. A.; Garg, D.; Kapp, T. G.; Will, C. L.; Demme, O.; Lührmann, R.; Kessler, H.; Sattler, M.: Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), S. 10190 - 10197 (2016)
40.
Zeitschriftenartikel
Absmeier, E.; Wollenhaupt, J.; Mozaffari-Jovin, S.; Becke, C.; Lee, C. T.; Preussner, M.; Heyd, F.; Urlaub, H.; Lührmann, R.; Santos, K. F. et al.; Wahl, M. C.: The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 29 (24), S. 2576 - 2587 (2015)
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