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Journal Article (184)
21.
Journal Article
45 (11), pp. 6729 - 6745 (2017)
SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 22.
Journal Article
64 (2), pp. 307 - 319 (2016)
Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 23.
Journal Article
353 (6306), pp. 1399 - 1405 (2016)
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 24.
Journal Article
22 (9), pp. 1329 - 1337 (2016)
ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 25.
Journal Article
22 (9), pp. 1427 - 1440 (2016)
A protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA 26.
Journal Article
7, 11997 (2016)
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 27.
Journal Article
5, e15564 (2016)
The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 28.
Journal Article
351 (6280), pp. 1416 - 1420 (2016)
Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 29.
Journal Article
13 (3), pp. 320 - 330 (2016)
Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology 30.
Journal Article
22 (2), pp. 265 - 277 (2016)
Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 31.
Journal Article
72 (2), pp. 112 - 120 (2016)
Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 32.
Journal Article
59 (22), pp. 10190 - 10197 (2016)
Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 33.
Journal Article
29 (24), pp. 2576 - 2587 (2015)
The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 34.
Journal Article
34 (24), pp. 3059 - 3073 (2015)
Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 35.
Journal Article
11 (9), e1005539 (2015)
Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 36.
Journal Article
21 (11), pp. 1993 - 2005 (2015)
Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 37.
Journal Article
125 (9), pp. 3572 - 3584 (2015)
HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 38.
Journal Article
162 (3), pp. 690 - 690.e1 (2015)
Snapshot: Spliceosome dynamics III. Cell 39.
Journal Article
162 (2), pp. 456 - 456.e1 (2015)
SnapShot: Spliceosome dynamics II. Cell 40.
Journal Article
4, e07320 (2015)
A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife