Publications of R. Lührmann

Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), pp. 318 - 323 (2017)

Tauchert, M. J.; Fourmann, J. B.; Lührmann, R.; Ficner, R.: Structural insights into the mechanism of the DEAH-box RNA helicase Prp43. eLife 6, e21510 (2017)

Pozzi, B.; Bragado, L.; Will, C. L.; Mammi, P.; Risso, G.; Urlaub, H.; Lührmann, R.; Srebrow, A.: SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 45 (11), pp. 6729 - 6745 (2017)

Cretu, C.; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De Laurentiis, E.; Sharma, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 64 (2), pp. 307 - 319 (2016)

Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), pp. 1399 - 1405 (2016)

Agafonov, D. E.; van Santen, M.; Kastner, B.; Dube, P.; Will, C. L.; Urlaub, H.; Lührmann, R.: ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 22 (9), pp. 1329 - 1337 (2016)

Sun, C.; Rigo, N.; Fabrizio, P.; Kastner, B.; Lührmann, R.: A protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA 22 (9), pp. 1427 - 1440 (2016)

Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Ficner, R.; Will, C. L.; Lührmann, R.: A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 7, 11997 (2016)

Fourmann, J. B.; Dybkov, O.; Agafonov, D. E.; Tauchert, M. J.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 5, e15564 (2016)

Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.; Urlaub, H.; Lührmann, R.; Stark, H.: Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), pp. 1416 - 1420 (2016)

Heininger, A. U.; Hackert, P.; Andreou, A. Z.; Boon, K. L.; Memet, I.; Prior, M.; Clancy, A.; Schmidt, B.; Urlaub, H.; Schleiff, E. et al.; Sloan, K. E.; Deckers, M.; Lührmann, R.; Enderlein, J.; Klostermeier, D.; Rehling, P.; Bohnsack, M. T.: Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology 13 (3), pp. 320 - 330 (2016)

Schütze, T.; Ulrich, A. K. C.; Apelt, L.; Will, C. L.; Bartlick, N.; Seeger, M.; Weber, G.; Lührmann, R.; Stelzl, U.; Wahl, M. C.: Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 22 (2), pp. 265 - 277 (2016)

Tauchert, M. J.; Fourmann, J. B.; Christian, H.; Lührmann, R.; Ficner, R.: Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 72 (2), pp. 112 - 120 (2016)

Jagtap, P. K. A.; Garg, D.; Kapp, T. G.; Will, C. L.; Demme, O.; Lührmann, R.; Kessler, H.; Sattler, M.: Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), pp. 10190 - 10197 (2016)

Absmeier, E.; Wollenhaupt, J.; Mozaffari-Jovin, S.; Becke, C.; Lee, C. T.; Preussner, M.; Heyd, F.; Urlaub, H.; Lührmann, R.; Santos, K. F. et al.; Wahl, M. C.: The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 29 (24), pp. 2576 - 2587 (2015)

Rigo, N.; Sun, C.; Fabrizio, P.; Kastner, B.; Lührmann, R.: Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 34 (24), pp. 3059 - 3073 (2015)

Schneider, C.; Agafonov, D. E.; Schmitzova, J.; Hartmuth, K.; Fabrizio, P.; Lührmann, R.: Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 11 (9), e1005539 (2015)

Boesler, C.; Rigo, N.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Will, C. L.; Lührmann, R.: Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 21 (11), pp. 1993 - 2005 (2015)

Benito, E.; Urbanke, H.; Ramachandran, B.; Barth, J.; Halder, R.; Awasthi, A.; Jain, G.; Capece, J. G.; Burkhardt, S.; Navarro-Sala, M. et al.; Nagarajan, S.; Schütz, A. L.; Johnsen, S. A.; Bonn, S.; Lührmann, R.; Dean, C.; Fischer, A.: HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 125 (9), pp. 3572 - 3584 (2015)

Wahl, M. C.; Lührmann, R.: Snapshot: Spliceosome dynamics III. Cell 162 (3), pp. 690 - 690.e1 (2015)