Search results

Journal Article (10)

  1. 1.
    Journal Article
    Wang, Y.; Telmer, C. A.; Schmidt, B. F.; Franke, J. D.; Ort, S.; Arndt-Jovin, D. J.; Bruchez, M. P.: Fluorogen activating protein–affibody probes: modular, no-wash measurement of epidermal growth factor receptors. Bioconjugate Chemistry 26 (1), pp. 137 - 144 (2015)
  2. 2.
    Journal Article
    Hazra, S.; Szewczak, A.; Ort, S.; Konrad, M.; Lavie, A.: Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release. Biochemistry 50 (14), pp. 2870 - 2880 (2011)
  3. 3.
    Journal Article
    Hazra, S.; Ort, S.; Konrad, M.; Lavie, A.: Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues. Biochemistry 49 (31), pp. 6784 - 6790 (2010)
  4. 4.
    Journal Article
    Hazra, S.; Sabini, E.; Ort, S.; Konrad, M.; Lavie, A.: Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. Biochemistry 48 (6), pp. 1256 - 1263 (2009)
  5. 5.
    Journal Article
    Sabini, E.; Hazra, S.; Ort, S.; Konrad, M.; Lavie, A.: Structural basis for substrate promiscuity of dCK. Journal of Molecular Biology 378 (3), pp. 607 - 621 (2008)
  6. 6.
    Journal Article
    McSorley, T.; Ort, S.; Hazra, S.; Lavie, A.; Konrad, M.: Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues. FEBS Letters 582 (5), pp. 720 - 724 (2008)
  7. 7.
    Journal Article
    Sekulic, N.; Dietrich, K.; Paarmann, I.; Ort, S.; Konrad, M.; Lavie, A.: Elucidation of the active conformation of the APS-kinase domain of human PAPS synthetase 1. Journal of Molecular Biology 367 (2), pp. 488 - 500 (2007)
  8. 8.
    Journal Article
    Godsey, M. H.; Ort, S.; Sabini, E.; Konrad, M.; Lavie, A.: Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: Illuminating the role of main-chain reorganization. Biochemistry 45 (2), pp. 452 - 461 (2006)
  9. 9.
    Journal Article
    Segura-Pena, D.; Sekulic, N.; Ort, S.; Konrad, M.; Lavie, A.: Substrate-induced conformational changes in human UMP/CMP kinase. Journal of Biological Chemistry 279 (32), pp. 33882 - 33889 (2004)
  10. 10.
    Journal Article
    Sabini, E.; Ort, S.; Monnerjahn, C.; Konrad, M.; Lavie, A.: Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Nature Structural Biology 10 (7), pp. 513 - 519 (2003)

Conference Paper (3)

  1. 11.
    Conference Paper
    Konrad, M.; McSorley, T.; Lavie, A.; Ort, S.: Design and intracellular delivery of enzymes to enhance metabolic activation of prodrugs and improve anticancer therapy. FEBS Journal 275 (Suppl. 1), p. 168 - 168 (2008)
  2. 12.
    Conference Paper
    Konrad, M.; Ort, S.; Monnerjahn, C.; Lavie, A.: Engineering of nucleoside kinases to improve the activation of nucleoside analog prodrugs. FEBS Journal 273 (Suppl. 1), p. 50 - 50 (2006)
  3. 13.
    Conference Paper
    Segura, D.; Sekulic, N.; Ort, S.; Konrad, M.; Lavie, A.: Substrate-induced conformational changes in human UMP/CMP kinase. Protein Science 13 (Suppl. 1), p. 190 - 190 (2004)

Thesis - PhD (1)

  1. 14.
    Thesis - PhD
    Ort, S.: Proteindesign zur Verbesserung des Nukleosidanaloga-Umsatzes in menschlichen Zellen: Desoxycytidin-Kinase und UMP/CMP-Kinase. Dissertation, Universität Göttingen, Göttingen (2005)
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