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Journal Article (59)
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1.Journal ArticleStructural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 11 (11), a032417 (2019)
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2.Journal ArticleSmu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications 10 (1) (2019)
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3.Journal ArticleMultiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research 46 (22), pp. 12126 - 12138 (2018)
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4.Journal ArticleThe Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation. Nucleic Acids Research 46 (7), pp. 3774 - 3790 (2018)
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5.Journal ArticleStructural basis of splicing modulation by antitumor macrolide compounds. Molecular Cell 70 (2), pp. 265 - 273 (2018)
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6.Journal ArticleThe RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development 31 (23-24), pp. 2416 - 2429 (2017)
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7.Journal ArticleCryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), pp. 701 - 713, e1 - e4 (2017)
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8.Journal ArticleIdentification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 6 (2017)
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9.Journal ArticleCryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), pp. 318 - 323 (2017)
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10.Journal ArticleSUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 45 (11), pp. 6729 - 6745 (2017)
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11.Journal ArticleMolecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 64 (2), pp. 307 - 319 (2016)
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12.Journal ArticleATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 22 (9), pp. 1329 - 1337 (2016)
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13.Journal ArticleU6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III. Scientific Reports 6 (2016)
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14.Journal ArticleA spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 7 (2016)
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15.Journal ArticleMultiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 22 (2), pp. 265 - 277 (2016)
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16.Journal ArticleRational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), pp. 10190 - 10197 (2016)
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17.Journal ArticleStable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 21 (11) (2015)
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18.Journal ArticleThe RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 22 (2) (2015)
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19.Journal ArticleNovel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 11 (4), pp. 298 - 312 (2014)
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20.Journal ArticleThe Prp19 complex directly functions in mitotic spindle assembly. PLoS One 8 (9) (2013)