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Journal Article (59)

1. MPG.PuRe

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   Keiper, S. M.; Papasaikas, P.; Will, C. L.; Valcárcel, J.; Girard, C.; Lührmann, R.: Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications 10 (1) (2019)
2. MPG.PuRe

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   Kastner, B.; Will, C. L.; Stark, H.; Lührmann, R.: Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology (2019)
3. MPG.PuRe

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   Bao, P.; Boon, K. L.; Will, C. L.; Hartmuth, K.; Lührmann, R.: Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research 46 (22), pp. 12126 - 12138 (2018)
4. MPG.PuRe

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   Roithová, A.; Klimešová, K.; Pánek, J.; Will, C. L.; Lührmann, R.; Stanek, D.; Girard, C.: The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation. Nucleic Acids Research 46 (7), pp. 3774 - 3790 (2018)
5. MPG.PuRe

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   Cretu, C.; Agrawal, A. A.; Cook, A.; Will, C. L.; Fekkes, P.; Smith, P. G.,.; Lührmann, R.; Larsen, N.; Buonamici, S.; Pena, V.: Structural basis of splicing modulation by antitumor macrolide compounds. Molecular Cell 70 (2), pp. 265 - 273 (2018)
6. MPG.PuRe

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   Bao, P.; Will, C. L.; Urlaub, H.; Boon, K. L.; Lührmann, R.: The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development 31 (23-24), pp. 2416 - 2429 (2017)
7. MPG.PuRe

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   Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), pp. 701 - 713, e1 - e4 (2017)
8. MPG.PuRe

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   Sidarovich, A.; Will, C. L.; Anokhina, M. M.; Ceballos, J.; Sievers, S.; Agafonov, D. E.; Samatov, T.; Bao, P.; Kastner, B.; Urlaub, H. et al.; Waldmann, H.; Lührmann, R.: Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 6 (2017)
9. MPG.PuRe

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   Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), pp. 318 - 323 (2017)
10. MPG.PuRe

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    ZIP
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    Pozzi, B.; Bragado, L.; Will, C. L.; Mammi, P.; Risso, G.; Urlaub, H.; Lührmann, R.; Srebrow, A.: SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 45 (11), pp. 6729 - 6745 (2017)
11. MPG.PuRe

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    Cretu, C.; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De Laurentiis, E.; Sharma, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 64 (2), pp. 307 - 319 (2016)
12. MPG.PuRe

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    Agafonov, D. E.; van Santen, M.; Kastner, B.; Dube, P.; Will, C. L.; Urlaub, H.; Lührmann, R.: ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 22 (9), pp. 1329 - 1337 (2016)
13. MPG.PuRe

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    Singh, J.; Sikand, K.; Conrad, H.; Will, C. L.; Komar, A. A.; Shukla, G. C.: U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III. Scientific Reports 6 (2016)
14. MPG.PuRe

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    Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Ficner, R.; Will, C. L.; Lührmann, R.: A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 7 (2016)
15. MPG.PuRe

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    Schütze, T.; Ulrich, A. K. C.; Apelt, L.; Will, C. L.; Bartlick, N.; Seeger, M.; Weber, G.; Lührmann, R.; Stelzl, U.; Wahl, M. C.: Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 22 (2), pp. 265 - 277 (2016)
16. MPG.PuRe

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    Jagtap, P. K. A.; Garg, D.; Kapp, T. G.; Will, C. L.; Demme, O.; Lührmann, R.; Kessler, H.; Sattler, M.: Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), pp. 10190 - 10197 (2016)
17. MPG.PuRe

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    Boesler, C.; Rigo, N.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Will, C. L.; Lührmann, R.: Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 21 (11) (2015)
18. MPG.PuRe

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    De, I.; Bessonov, S.; Hofele, R.; Dos Santos, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: The RNA helicase ​Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 22 (2) (2015)
19. MPG.PuRe

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    Mozaffari-Jovin, S.; Wandersleben, T.; Santos, K. F.; Will, C. L.; Lührmann, R.; Wahl, M. C.: Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 11 (4), pp. 298 - 312 (2014)
20. MPG.PuRe

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    Hofmann, J. C.; Tegha-Dunghu, J.; Dräger, S.; Will, C. L.; Lührmann, R.; Gruss, O. J.: The Prp19 complex directly functions in mitotic spindle assembly. PLoS One 8 (9) (2013)