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Journal Article (89)
Journal Article
587 (7832), pp. 157 - 161 (2020)
Atomic-resolution protein structure determination by cryo-EM. Nature
Journal Article
80 (1), pp. 127 - 139.e6 (2020)
Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell
Journal Article
583 (7815), pp. 310 - 313 (2020)
Molecular architecture of the human 17S U2 snRNP. Nature
Journal Article
180 (6), pp. 1130 - 1143.e20 (2020)
Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell
Journal Article
11 (11), a032417 (2019)
Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology
Journal Article
116 (35), pp. 17280 - 17289 (2019)
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
27 (7), pp. 1124 - 1136 (2019)
Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure
Journal Article
29 (2), pp. 117 - 134 (2019)
Posing the APC/C E3 ubiquitin ligase to orchestrate cell division. Trends in Cell Biology
Journal Article
17 (7), pp. 471 - 492 (2018)
Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery
Journal Article
172 (3), pp. 454 - 464, e1-e5 (2018)
Structure and conformational dynamics of the human spliceosomal Bact complex. Cell
Journal Article
170 (4), pp. 701 - 713, e1 - e4 (2017)
Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell
Journal Article
8, 15578 (2017)
Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications
Journal Article
372 (1716), 20160182 (2017)
Ribosome dynamics during decoding. Philosophical Transactions of the Royal Society B
Journal Article
542 (7641), pp. 318 - 323 (2017)
Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature
Journal Article
540 (7631), pp. 80 - 85 (2016)
The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature
Journal Article
353 (6306), pp. 1399 - 1405 (2016)
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science
Journal Article
16 (12), pp. 3103 - 3112 (2016)
The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports
Journal Article
7, 12523 (2016)
Topology and structure of an engineered human cohesin complex bound to Pds5B. Nature Communications
Journal Article
63 (4), pp. 593 - 607 (2016)
Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation. Molecular Cell
Journal Article
353 (6299), pp. 594 - 598 (2016)
The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science