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Journal Article (185)
1.
Journal Article
371 (6526), pp. 305 - 309 (2021)
Structure of a transcribing RNA polymerase II–U1 snRNP complex. Science 2.
Journal Article
80 (1), pp. 127 - 139.e6 (2020)
Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 3.
Journal Article
583 (7815), pp. 310 - 313 (2020)
Molecular architecture of the human 17S U2 snRNP. Nature 4.
Journal Article
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Molecular Cell, (in press) (2020)
5.
Journal Article
26 (2), pp. vii - viii (2020)
Kiyoshi Nagai (1949-2019). RNA 6.
Journal Article
11 (11), a032417 (2019)
Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 7.
Journal Article
105 (3), pp. 573 - 587 (2019)
Pathogenic abnormal splicing due to intronic deletions that induce biophysical space constraint for spliceosome assembly. American Journal of Human Genetics 8.
Journal Article
10 (1), 3639 (2019)
Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications 9.
Journal Article
46 (22), pp. 12126 - 12138 (2018)
Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research 10.
Journal Article
9, 4234 (2018)
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications 11.
Journal Article
46 (7), pp. 3774 - 3790 (2018)
The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation. Nucleic Acids Research 12.
Journal Article
70 (2), pp. 265 - 273 (2018)
Structural basis of splicing modulation by antitumor macrolide compounds. Molecular Cell 13.
Journal Article
69 (6), pp. 979 - 992 (2018)
Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell 14.
Journal Article
172 (3), pp. 454 - 464, e1-e5 (2018)
Structure and conformational dynamics of the human spliceosomal Bact complex. Cell 15.
Journal Article
23 (12), pp. 1770 - 1779 (2017)
Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing. RNA 16.
Journal Article
31 (23-24), pp. 2416 - 2429 (2017)
The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development 17.
Journal Article
170 (4), pp. 701 - 713, e1 - e4 (2017)
Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 18.
Journal Article
45 (7), pp. 4068 - 4080 (2017)
Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2. Nucleic Acids Research 19.
Journal Article
6, e23533 (2017)
Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 20.
Journal Article
542 (7641), pp. 318 - 323 (2017)
Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature