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Journal Article (181)

  1. 21.
    Journal Article
    Sun, C.; Rigo, N.; Fabrizio, P.; Kastner, B.; Lührmann, R.: A protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA 22 (9), pp. 1427 - 1440 (2016)
  2. 22.
    Journal Article
    Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Ficner, R.; Will, C. L.; Lührmann, R.: A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 7 (2016)
  3. 23.
    Journal Article
    Fourmann, J. B.; Dybkov, O.; Agafonov, D. E.; Tauchert, M. J.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 5 (2016)
  4. 24.
    Journal Article
    Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.; Urlaub, H.; Lührmann, R.; Stark, H.: Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), pp. 1416 - 1420 (2016)
  5. 25.
    Journal Article
    Heininger, A. U.; Hackert, P.; Andreou, A. Z.; Boon, K. L.; Memet, I.; Prior, M.; Clancy, A.; Schmidt, B.; Urlaub, H.; Schleiff, E. et al.; Sloan, K. E.; Deckers, M.; Lührmann, R.; Enderlein, J.; Klostermeier, D.; Rehling, P.; Bohnsack, M. T.: Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology 13 (3), pp. 320 - 330 (2016)
  6. 26.
    Journal Article
    Schütze, T.; Ulrich, A. K. C.; Apelt, L.; Will, C. L.; Bartlick, N.; Seeger, M.; Weber, G.; Lührmann, R.; Stelzl, U.; Wahl, M. C.: Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 22 (2), pp. 265 - 277 (2016)
  7. 27.
    Journal Article
    Tauchert, M. J.; Fourmann, J. B.; Christian, H.; Lührmann, R.; Ficner, R.: Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 72 (2), pp. 112 - 120 (2016)
  8. 28.
    Journal Article
    Jagtap, P. K. A.; Garg, D.; Kapp, T. G.; Will, C. L.; Demme, O.; Lührmann, R.; Kessler, H.; Sattler, M.: Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), pp. 10190 - 10197 (2016)
  9. 29.
    Journal Article
    Absmeier, E.; Wollenhaupt, J.; Mozaffari-Jovin, S.; Becke, C.; Lee, C. T.; Preussner, M.; Heyd, F.; Urlaub, H.; Lührmann, R.; Santos, K. F. et al.; Wahl, M. C.: The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 29 (24), pp. 2576 - 2587 (2015)
  10. 30.
    Journal Article
    Rigo, N.; Sun, C.; Fabrizio, P.; Kastner, B.; Lührmann, R.: Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 34 (24), pp. 3059 - 3073 (2015)
  11. 31.
    Journal Article
    Schneider, C.; Agafonov, D. E.; Schmitzova, J.; Hartmuth, K.; Fabrizio, P.; Lührmann, R.: Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 11 (9) (2015)
  12. 32.
    Journal Article
    Boesler, C.; Rigo, N.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Will, C. L.; Lührmann, R.: Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 21 (11) (2015)
  13. 33.
    Journal Article
    Benito, E.; Urbanke, H.; Ramachandran, B.; Barth, J.; Halder, R.; Awasthi, A.; Jain, G.; Capece, J. G.; Burkhardt, S.; Navarro-Sala, M. et al.; Nagarajan, S.; Schütz, A. L.; Johnsen, S. A.; Bonn, S.; Lührmann, R.; Dean, C.; Fischer, A.: HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 125 (9), pp. 3572 - 3584 (2015)
  14. 34.
    Journal Article
    Wahl, M. C.; Lührmann, R.: Snapshot: Spliceosome dynamics III. Cell 162 (3) (2015)
  15. 35.
    Journal Article
    Wahl, M. C.; Lührmann, R.: SnapShot: Spliceosome dynamics II. Cell 162 (2), pp. 456 - 456.e1 (2015)
  16. 36.
    Journal Article
    Liu, S.; Mozaffari-Jovin, S.; Wollenhaupt, J.; Santos, , K. F.; Theuser, M.; Dunin-Horkawicz, S.; Fabrizio, P.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife 4 (2015)
  17. 37.
    Journal Article
    Wahl, M. C.; Lührmann, R.: SnapShot: Spliceosome dynamics I. Cell 161 (6) (2015)
  18. 38.
    Journal Article
    De, I.; Bessonov, S.; Hofele, R.; Dos Santos, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: The RNA helicase ​Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 22 (2) (2015)
  19. 39.
    Journal Article
    Warkocki, Z.; Schneider, C.; Mozaffari-Jovin, S.; Schmitzova, J.; Höbartner, C.; Fabrizio, P.; Lührmann, R.: The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development 29 (1), pp. 94 - 107 (2015)
  20. 40.
    Journal Article
    Pawellek, A.; McElroy, S.; Samatov, T.; Mitchell, L.; Woodland, A.; Ryder, U.; Gray, D.; Lührmann, R.; Lamond, A.: Identification of small molecule inhibitors of pre-mRNA splicing. The Journal of Biological Chemistry 289 (50), pp. 34683 - 34698 (2014)
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