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Journal Article (58)

  1. Journal Article
    Mozaffari-Jovin, S.; Santos, K. F.; Hsiao, H. H.; Will, C. L.; Urlaub, H.; Wahl, M. C.; Lührmann, R.: The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 26 (23), pp. 2422 - 2434 (2012)
  2. Journal Article
    Girard, C.; Will, C. L.; Peng, J.; Makarov, E. M.; Kastner, B.; Lemm, I.; Urlaub, H.; Hartmuth, K.; Lührmann, R.: Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 3 (2012)
  3. Journal Article
    Hegele, A.; Kamburov, A.; Grossmann, A.; Sourlis, C.; Wowro, S.; Weimann, M.; Will, C. L.; Pena, V.; Lührmann, R.; Stelzl, U.: Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 45 (4), pp. 567 - 580 (2012)
  4. Journal Article
    Agafonov, D. E.; Deckert, J.; Wolf, E.; Odenwälder, P.; Bessonov, S.; Will, C. L.; Urlaub, H.; Lührmann, R.: Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology 31 (13), pp. 2667 - 2682 (2011)
  5. Journal Article
    Popow, J.; Englert, M.; Weitzer, S.; Schleiffer, A.; Mierzwa, B.; Mechtler, K.; Trowitzsch, S.; Will, C. L.; Lührmann, R.; Soell, D. et al.; Martinez, J.: HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 331 (6018), pp. 760 - 764 (2011)
  6. Journal Article
    Bessonov, S.; Anokhina, M.; Krasauskas, A.; Golas, M. M.; Sander, B.; Will, C. L.; Urlaub, H.; Stark, H.; Lührmann, R.: Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 16 (12), pp. 2384 - 2403 (2010)
  7. Journal Article
    Grote, M.; Wolf, E.; Will, C. L.; Lemm, I.; Agafonov, D. E.; Schomburg, A.; Fischle, W.; Urlaub, H.; Lührmann, R.: Molecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology 30 (9), pp. 2105 - 2119 (2010)
  8. Journal Article
    Schneider, M.; Will, C. L.; Anokhina, M.; Tazi, J.; Urlaub, H.; Lührmann, R.: Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Molecular Cell 38 (2), pp. 223 - 235 (2010)
  9. Journal Article
    Verbeeren, J.; Niemelae, E. H.; Turunen, J. J.; Will, C. L.; Ravanti, J. J.; Lührmann, R.; Frilander, M. J.: An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Molecular Cell 37 (6), pp. 821 - 833 (2010)
  10. Journal Article
    Schneider, M.; Hsiao, H. H.; Will, C. L.; Giet, R.; Urlaub, H.; Lührmann, R.: Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural and Molecular Biology 17 (2), pp. 216 - 222 (2010)
  11. Journal Article
    Wahl, M. C.; Will, C. L.; Lührmann, R.: The spliceosome: design principles of a dynamic RNP machine. Cell 136 (4), pp. 701 - 718 (2009)
  12. Journal Article
    Herold, N.; Will, C. L.; Wolf, E.; Kastner, B.; Urlaub, H.; Lührmann, R.: Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Molecular and Cellular Biology 29 (1), pp. 281 - 301 (2009)
  13. Journal Article
    Pessa, H. K.; Will, C. L.; Meng, X.; Schneider, C.; Watkins, N. J.; Peraelae, N.; Nymark, M.; Turunen, J. J.; Luehrmann, R.; Frilander, M. J.: Minor spliceosome components are predominantly localized in the nucleus. Proceedings of the National Academy of Sciences of the United States of America 105, pp. 8655 - 8660 (2008)
  14. Journal Article
    Turunen, J. J.; Will, C. L.; Grote, M.; Luehrmann, R.; Frilander, M. J.: The U11-48K protein contacts the 5' splice site of U12-Type introns and the U11-59K protein. Molecular and Cellular Biology 28 (10), pp. 3548 - 3560 (2008)
  15. Journal Article
    Bessonov, S.; Anokhina, M.; Will, C. L.; Urlaub, H.; Luehrmann, R.: Isolation of an active step I spliceosome and composition of its RNP core. Nature 452 (7189), pp. 846 - 850 (2008)
  16. Journal Article
    Behzadnia, N.; Golas, M. M.; Hartmuth, K.; Sander, B.; Kastner, B.; Deckert, J.; Dube, P.; Will, C. L.; Urlaub, H.; Stark, H. et al.; Luehrmann, R.: Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. The EMBO Journal 26 (6), pp. 1737 - 1748 (2007)
  17. Journal Article
    Doenmez, G.; Hartmuth, K.; Kastner, B.; Will, C. L.; Luehrmann, R.: The 5′ end of U2 snRNA is in close proximity to U1 and functional sites of the Pre-mRNA in early spliceosomal complexes. Molecular Cell 25 (3), pp. 399 - 411 (2007)
  18. Journal Article
    Merz, C.; Urlaub, H.; Will, C. L.; Luehrmann, R.: Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment. RNA 13, pp. 116 - 128 (2007)
  19. Journal Article
    Deckert, J.; Hartmuth, K.; Boehringer, D.; Behzadnia, N.; Will, C. L.; Kastner, B.; Stark, H.; Urlaub, H.; Luehrmann, R.: Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Molecular and Cellular Biology 26 (14), pp. 5528 - 5543 (2006)
  20. Journal Article
    Dybkov, O.; Will, C. L.; Deckert, J.; Behzadnia, N.; Hartmuth, K.; Luehrmann, R.: U2 snRNA-protein contacts in purified human 17S U2 snRNPs and in spliceosomal A and B complexes. Molecular and Cellular Biology 26 (7), pp. 2803 - 2816 (2006)
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