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Journal Article (7)

  1. Journal Article
    Karamitros, C. S.; Konrad, M.: Fluorescence-activated cell sorting of human l-asparaginase mutant libraries for detecting enzyme variants with enhanced activity. ACS Chemical Biology 11 (9), pp. 2596 - 2607 (2016)
  2. Journal Article
    Karamitros, C. S.; Konrad, M.: Human 60-kDa lysophospholipase contains an N-terminal l-asparaginase domain that is allosterically regulated by l-asparagine. The Journal of Biological Chemistry 289 (19), pp. 12962 - 12975 (2014)
  3. Journal Article
    Karamitros, C. S.; Yashchenok, A. M.; Moehwald, H.; Skirtach, A. G.; Konrad, M.: Preserving catalytic activity and enhancing biochemical stability of the therapeutic enzyme asparaginase by biocompatible multi layered polyelectrolyte microcapsules. Biomacromolecules 14 (12), pp. 4398 - 4406 (2013)
  4. Journal Article
    Lim, J.; Vrignon, J.; Gruner, P.; Karamitros, C. S.; Konrad, M.; Baret, J. C.: Ultra-high throughput detection of single cell beta-galactosidase activity in droplets using micro-optical lens array. Applied Physics Letters 103 (20) (2013)
  5. Journal Article
    Karamitros, C. S.; Konrad, M.: Bacterial co-expression of the alpha and beta protomers of human L-asparaginase-3: Achieving essential N-terminal exposure of a catalytically critical threonine located in the beta-subunit. Protein Expression and Purification 93 (2013)
  6. Journal Article
    Karamitros, C. S.; Lim, J.; Konrad, M.: An Amplex Red-based fluorometric and spectrophotometric assay for L-asparaginase using its natural substrate. Analytical Biochemistry 445 (2013)
  7. Journal Article
    Su, Y.; Karamitros, C. S.; Nomme, J.; McSorley, T.; Konrad, M.; Lavie, A.: Free glycine accelerates the autoproteolytic activation of human asparaginase. Chemistry and Biology 20 (4), pp. 533 - 540 (2013)

Conference Paper (3)

  1. Conference Paper
    Karamitros, C. S.; Konrad, M.: L-asparaginases as therapeutic enzymes for the treatment of leukemia. 9th International Conference of Anticancer Research, Sithonia, Greece, October 06, 2014 - October 10, 2014. Anticancer Research 34, p. 6004 - 6004 (2014)
  2. Conference Paper
    Konrad, M.; Karamitros, C. S.: Molecular engineering of L-asparaginases as therapeutic enzymes for the treatment of leukemia. 28th Annual Symposium of the Protein-Society, San Diego, CA, July 27, 2014 - July 30, 2014. Protein Science 23 (Supplement 1), pp. 79 - 80 (2014)
  3. Conference Paper
    Konrad, M.; Karamitros, C. S.; Lavie, A.: Therapeutic enzymes for the treatment of leukemia: Autoproteolytic activation of human asparaginase induced by free glycine. 38th Congress of the Federation-of-European-Biochemical-Societies (FEBS) , Saint Petersburg, RUSSIA, July 06, 2013 - July 11, 2013. FEBS Journal 280 (Supplement 1), pp. 326 - 327 (2013)

Thesis - PhD (1)

  1. Thesis - PhD
    Karamitros, C. S.: Biochemical characterization and engineering of L-asparaginases for amino acid depletion therapy of acute lymphoblastic leukemia. Dissertation, XV, 285 pp., Georg-August-Universität, Göttingen (2014)
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