Publications of Ashwin Chari

Journal Article (43)

1.
Journal Article
Soh, W. T.; Roetschke, H. P.; Cormican, J. A.; Teo, B.F.; Chiam, N. C.; Raabe, M.; Pflanz, R.; Henneberg, F.; Becker, S.; Chari, A. et al.; Liu, H.; Urlaub, H.; Liepe, J.; Mishto, M.: Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing. Nature Communications 15 (1), 1147 (2024)
2.
Journal Article
Funk, L.-M.; Poschmann, G.; Rabe von Pappenheim, F.; Chari, A.; Stegmann, K. M.; Dickmanns, A.; Wensien, M.; Eulig, N.; Paknia, E.; Heyne, G. et al.; Penka, E.; Pearson, A. R.; Berndt, C.; Fritz, T.; Bazzi, S.; Uranga, J.; Mata, R. A.; Dobbelstein, M.; Hilgenfeld, R.; Curth, U.; Tittmann, K.: Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nature Communications 15, 411 (2024)
3.
Journal Article
Chari, A.; Stark, H.: Prospects and Limitations of High-Resolution Single-Particle Cryo-Electron Microscopy. Annual Review of Biophysics 52, pp. 391 - 411 (2023)
4.
Journal Article
Donath, T.; Šišak Jung, D.; Burian, M.; Radicci, V.; Zambon, P.; Fitch, A. N.; Dejoie, C.; Zhang, B.; Ruat, M.; Hanfland, M. et al.; Kewish, C. M.; van Riessen, G. A.; Naumenko, D.; Amenitsch, H.; Bourenkov, G.; Bricogne, G.; Chari, A.; Schulze-Briese, C.: EIGER2 hybrid-photon-counting X-ray detectors for advanced synchrotron diffraction experiments. Journal of Synchrotron Radiation, pp. 723 - 738 (2023)
5.
Journal Article
Singh, K.; Bunzel, G.; Graf, B.; Yip, K. M.; Neumann-Schaal, M.; Stark, H.; Chari, A.: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell 186 (23), e16, pp. 5054 - 5067 (2023)
6.
Journal Article
Yi, S.-H.; Petrychenko, V.; Schliep, J. E.; Goyal, A.; Linden, A.; Chari, A.; Urlaub, H.; Stark, H.; Rodnina, M. V.; Adio, S. et al.; Fischer, N.: Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Research 50 (9), pp. 5282 - 5298 (2022)
7.
Journal Article
Henneberg, F.; Chari, A.: Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 11, 1289 (2021)
8.
Journal Article
Henneberg, F.; Chari, A.: Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 11 (12), 1289 (2021)
9.
Journal Article
Yip, K. M.; Fischer, N.; Paknia, E.; Chari, A.; Stark, H.: Atomic-resolution protein structure determination by cryo-EM. Nature 587 (7832), pp. 157 - 161 (2020)
10.
Journal Article
Ukmar-Godec, T.; Fang, P.; Ibáñez de Opakua, A.; Henneberg, F.; Godec, A.; Pan, K. T.; Cima-Omori, M.-S.; Chari, A.; Mandelkow, E.; Urlaub, H. et al.; Zweckstetter, M.: Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 6 (30), eaba3916 (2020)
11.
Journal Article
Singh, K.; Graf, B.; Linden, A.; Sautner, V.; Urlaub, H.; Tittmann, K.; Stark, H.; Chari, A.: Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell 180 (6), pp. 1130 - 1143.e20 (2020)
12.
Journal Article
Prajapati, S.; Haselbach, D.; Wittig, S.; Patel, M. S.; Chari, A.; Schmidt, C.; Stark, H.; Tittmann, K.: Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure 27 (7), pp. 1124 - 1136 (2019)
13.
Journal Article
Renaud, J. P.; Chari, A.; Ciferri, C.; Liu, W.; Rémigy, H. W.; Stark, H.; Wiesmann, C.: Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery 17 (7), pp. 471 - 492 (2018)
14.
Journal Article
Haselbach, D.; Schrader, J.; Lambrecht, F.; Henneberg, F.; Chari, A.; Stark, H.: Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications 8, 15578 (2017)
15.
Journal Article
Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), pp. 1399 - 1405 (2016)
16.
Journal Article
Paknia, E.; Chari, A.; Stark, H.; Fischer, U.: The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports 16 (12), pp. 3103 - 3112 (2016)
17.
Journal Article
Schrader, J.; Henneberg, F.; Mata, R. A.; Tittmann, K.; Schneider, T. R.; Stark, H.; Bourenkov, G.; Chari, A.: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science 353 (6299), pp. 594 - 598 (2016)
18.
Journal Article
Stark, H.; Chari, A.: Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy. Microscopy 65 (1), pp. 23 - 34 (2016)
19.
Journal Article
Chari, A.; Haselbach, D.; Kirves, J. M.; Ohmer, J.; Paknia, E.; Fischer, N.; Ganichkin, O.; Moller, V.; Frye, J. J.; Petzold, G. et al.; Jarvis, M.; Tietzel, M.; Grimm, C.; Peters, J. M.; Schulman, B. A.; Tittmann, K.; Markl, J.; Fischer, U.; Stark, H.: ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods 12 (9), pp. 859 - 865 (2015)
20.
Journal Article
Neuenkirchen, N.; Englbrecht, C.; Ohmer, J.; Ziegenhals, T.; Chari, A.; Fischer, U.: Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization. EMBO Journal 34 (14), pp. 1925 - 1941 (2015)
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