Suchergebnisse

Zeitschriftenartikel (7)

  1. Zeitschriftenartikel
    Karamitros, C. S.; Konrad, M.: Fluorescence-activated cell sorting of human l-asparaginase mutant libraries for detecting enzyme variants with enhanced activity. ACS Chemical Biology 11 (9), S. 2596 - 2607 (2016)
  2. Zeitschriftenartikel
    Karamitros, C. S.; Konrad, M.: Human 60-kDa lysophospholipase contains an N-terminal l-asparaginase domain that is allosterically regulated by l-asparagine. The Journal of Biological Chemistry 289 (19), S. 12962 - 12975 (2014)
  3. Zeitschriftenartikel
    Karamitros, C. S.; Yashchenok, A. M.; Moehwald, H.; Skirtach, A. G.; Konrad, M.: Preserving catalytic activity and enhancing biochemical stability of the therapeutic enzyme asparaginase by biocompatible multi layered polyelectrolyte microcapsules. Biomacromolecules 14 (12), S. 4398 - 4406 (2013)
  4. Zeitschriftenartikel
    Lim, J.; Vrignon, J.; Gruner, P.; Karamitros, C. S.; Konrad, M.; Baret, J. C.: Ultra-high throughput detection of single cell beta-galactosidase activity in droplets using micro-optical lens array. Applied Physics Letters 103 (20) (2013)
  5. Zeitschriftenartikel
    Karamitros, C. S.; Konrad, M.: Bacterial co-expression of the alpha and beta protomers of human L-asparaginase-3: Achieving essential N-terminal exposure of a catalytically critical threonine located in the beta-subunit. Protein Expression and Purification 93 (2013)
  6. Zeitschriftenartikel
    Karamitros, C. S.; Lim, J.; Konrad, M.: An Amplex Red-based fluorometric and spectrophotometric assay for L-asparaginase using its natural substrate. Analytical Biochemistry 445 (2013)
  7. Zeitschriftenartikel
    Su, Y.; Karamitros, C. S.; Nomme, J.; McSorley, T.; Konrad, M.; Lavie, A.: Free glycine accelerates the autoproteolytic activation of human asparaginase. Chemistry and Biology 20 (4), S. 533 - 540 (2013)

Konferenzbeitrag (3)

  1. Konferenzbeitrag
    Karamitros, C. S.; Konrad, M.: L-asparaginases as therapeutic enzymes for the treatment of leukemia. 9th International Conference of Anticancer Research, Sithonia, Greece, 06. Oktober 2014 - 10. Oktober 2014. Anticancer Research 34, S. 6004 - 6004 (2014)
  2. Konferenzbeitrag
    Konrad, M.; Karamitros, C. S.: Molecular engineering of L-asparaginases as therapeutic enzymes for the treatment of leukemia. 28th Annual Symposium of the Protein-Society, San Diego, CA, 27. Juli 2014 - 30. Juli 2014. Protein Science 23 (Supplement 1), S. 79 - 80 (2014)
  3. Konferenzbeitrag
    Konrad, M.; Karamitros, C. S.; Lavie, A.: Therapeutic enzymes for the treatment of leukemia: Autoproteolytic activation of human asparaginase induced by free glycine. 38th Congress of the Federation-of-European-Biochemical-Societies (FEBS) , Saint Petersburg, RUSSIA, 06. Juli 2013 - 11. Juli 2013. FEBS Journal 280 (Supplement 1), S. 326 - 327 (2013)

Hochschulschrift - Doktorarbeit (1)

  1. Hochschulschrift - Doktorarbeit
    Karamitros, C. S.: Biochemical characterization and engineering of L-asparaginases for amino acid depletion therapy of acute lymphoblastic leukemia. Dissertation, XV, 285 S., Georg-August-Universität, Göttingen (2014)
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