Suchergebnisse

Rocha de Moura, T.; Mozaffari-Jovin, S.; Szabo, C. Z. K.; Schmitzova, J.; Dybkov, O.; Cretu, C.; Kachala, M.; Svergun, D.; Urlaub, H.; Lührmann, R. et al.; Pena, V.: Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell 69 (6), S. 979 - 992 (2018)

Absmeier, E.; Wollenhaupt, J.; Mozaffari-Jovin, S.; Becke, C.; Lee, C. T.; Preussner, M.; Heyd, F.; Urlaub, H.; Lührmann, R.; Santos, K. F. et al.; Wahl, M. C.: The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 29 (24), S. 2576 - 2587 (2015)

Liu, S.; Mozaffari-Jovin, S.; Wollenhaupt, J.; Santos, , K. F.; Theuser, M.; Dunin-Horkawicz, S.; Fabrizio, P.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife 4, e07320 (2015)

Warkocki, Z.; Schneider, C.; Mozaffari-Jovin, S.; Schmitzova, J.; Höbartner, C.; Fabrizio, P.; Lührmann, R.: The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development 29 (1), S. 94 - 107 (2015)

Mozaffari-Jovin, S.; Wandersleben, T.; Santos, K. F.; Will, C. L.; Lührmann, R.; Wahl, M. C.: Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 11 (4), S. 298 - 312 (2014)

Mozaffari-Jovin, S.; Wandersleben, T.; Santos, K. F.; Will, C. L.; Lührmann, R.; Wahl, M. C.: Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 341 (6141), S. 80 - 84 (2013)

Weber, G.; Cristao, V. F.; Santos, K. F.; Mozaffari-Jovin, S.; Heroven, A. C.; Holton, N.; Lührmann, R.; Beggs, J. D.; Wahl, M. C.: Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes and Development 27 (5), S. 525 - 540 (2013)

Mozaffari-Jovin, S.; Santos, K. F.; Hsiao, H. H.; Will, C. L.; Urlaub, H.; Wahl, M. C.; Lührmann, R.: The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 26 (23), S. 2422 - 2434 (2012)

Santos , K. F.; Mozaffari-Jovin, S.; Weber , G.; Pena, V.; Lührmann, R.; Wahl, M. C.: Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America 109 (43), S. 17418 - 17423 (2012)

Pena, V.; Jovin, S. M.; Fabrizio, P.; Orlowski, J.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Molecular Cell 35 (4), S. 454 - 466 (2009)

Yildirim, A.; Jovin, S.; Wallisch, A. K.; Ries, J.; Urlaub, H.; Lührmann, R.; Wolfrum, U.: The ciliopathy protein SANS (Usher syndrome 1G) regulates pre-mRNA splicing by facilitating the maturation of the spliceosomal tri-snRNP complex. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, Canada, 28. April 2019 - 02. Mai 2019. Investigative Ophthalmology and Visual Science 60 (9), (2019)

Lako, M.; Buskin, A.; Zhu, L.; Chichagova, V.; Basu, B.; Mozaffari-Jovin, S.; Dolan, D.; Droop, A.; Collin, J.; Hilgen, G. et al.; Armstrong , L.; Sernagor, E.; Lührmann, R.; Grellscheid, S. N.; Johnson, C.: Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honululu, Haiti, 29. April 2018 - 03. Mai 2018. Investigative Ophthalmology and Visual Science 59 (9), (2018)

Mozaffari-Jovin, S.: Mechanism of regulation of spliceosome activation by Brr2 and Prp8 and links to retinal disease. Dissertation, Georg-August-Universität, Göttingen (2013)