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Structural Dynamics

The aim of our group is to determine three-dimensional structures of macromolecules with the single particle electron cryomicroscopy technique. Our work is mainly focused on spliceosomal components called snRNPs to obtain structural information about the eucaryotic pre-mRNA splicing. Apart from that we are working on ribosomal, viral and oxygen carrier projects. More detailed information is provided on our group website.



Press Releases & Research News

Ribosomal quality control

Ribosomal quality control

September 29, 2016

Formation of macromolecular machines within cells is often a complicated endeavor. Biochemists of the University of Würzburg and the MPI for Biophysical Chemistry have now unraveled new details of these processes. They show that cells invest a great deal of effort into preventing production errors. more

<p>Watching molecular machines at work</p>

An international team of scientists from Austria, Germany, and the United States has combined newly developed techniques in electron microscopy and protein assembly to elucidate how cells regulate one of the most important steps in cell division. more

Jahrbuchbeitrag (2013)
Macromolecular machines in 3D: The complex world of complexes
Tiny nano machines called macromolecular complexes participate in the most fundamental biological processes. The high-resolution three-dimensional (3D) structure of these complexes and their dynamic behavior can be studied by cryo electron microscopy. The molecular movies that can be obtained for these nano machines contribute tremendously to our understanding of molecular processes at a structural level. (in German) more
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