Structural Dynamics

The aim of our group is to determine three-dimensional structures of macromolecules with the single particle electron cryomicroscopy technique. Our work is mainly focused on spliceosomal components called snRNPs to obtain structural information about the eucaryotic pre-mRNA splicing. Apart from that we are working on ribosomal, viral and oxygen carrier projects. More detailed information is provided on our group website.

Press Releases & Research News

Tuberculosis still represents the infectious disease with the highest fatality numbers and is caused by mycobacteria. The fatty acid biosynthetic factory is an important target in the fight against this infectious bacterium. Göttingen researchers have now discovered a protein that commands and controls FAS function. This finding not only opens up new therapeutic venues, particularly against tuberculosis. In biotechnological applications this new control unit enables the generation of tailor-made fatty acid synthases.  more

Ribosomal quality control

September 29, 2016

Formation of macromolecular machines within cells is often a complicated endeavor. Biochemists of the University of Würzburg and the MPI for Biophysical Chemistry have now unraveled new details of these processes. They show that cells invest a great deal of effort into preventing production errors. more

Jahrbuchbeitrag (2013)
Macromolecular machines in 3D: The complex world of complexes
Tiny nano machines called macromolecular complexes participate in the most fundamental biological processes. The high-resolution three-dimensional (3D) structure of these complexes and their dynamic behavior can be studied by cryo electron microscopy. The molecular movies that can be obtained for these nano machines contribute tremendously to our understanding of molecular processes at a structural level. (in German) more
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