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Structure Determination of Proteins Using NMR

The goal of our research is to push NMR spectroscopy into new research areas and to provide insights at the molecular level into the factors that are responsible for the neurotoxicity of the proteins α-synuclein, Tau and Amyloid-β peptide during the course of Parkinson's and Alzheimer's diseases. In addition, we strive to obtain structure-function relationships for integral membrane proteins, such as the human voltage dependent anion channel.



Press Releases & Research News

It looks like a giant thermos flask and weighs eight tons. Not only because of that is the new 1.2 GHz spectrometer a heavy weight in the worldwide science community: With its magnetic field strength, it sets new standards in high resolution nuclear magnetic resonance (NMR) spectroscopy: 28.2 Tesla –almost 600,000 times stronger than the earth´s magnetic field. Presently, there are only three of these high tech instruments; in addition to Florence and Zurich, there is now one in Göttingen at the Max Planck Institute (MPI) for Biophysical Chemistry. more

For the first time, scientists in Göttingen have solved the high-resolution structure of the molecular transporter TSPO, which introduces cholesterol into mitochondria. This protein also serves as a docking site for diagnostic markers and different drugs, such as Valium. more

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