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Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association. Proceedings of the National Academy of Sciences of the United States of America 102.
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10 (1), 3603 (2019)
The pause-initiation limit restricts transcription activation in human cells. Nature Communicationsvolume 103.
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10 (1), 3138 (2019)
NASC-seq monitors RNA synthesis in single cells. Nature Communications 104.
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Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization. Journal of Biological Chemistry 105.
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Structural basis of TFIIH activation for nucleotide excision repair. Nature Communications 106.
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Transcriptome maps of general eukaryotic RNA degradation factors. eLife 107.
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74 (4), pp. 674 - 687 (2019)
MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation. Molecular Cell 108.
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294 (18), pp. 7528 - 7536 (2019)
Yeast mitochondrial protein Pet111p binds directly to two distinct targets in COX2 mRNA, suggesting a mechanism of translational activation. Journal of Biological Chemistry 109.
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116 (20), pp. 10048 - 10057 (2019)
Structure of the Ty3/Gypsy retrotransposon capsid and the evolution of retroviruses. Proceedings of the National Academy of Sciences of the United States of America 110.
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Global donor and acceptor splicing site kinetics in human cells. eLife 111.
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10 (1), e01966-18 (2019)
Functional metagenomics reveals an overlooked diversity and novel features of soil-derived bacterial phosphatases and phytases. mBio 112.
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176 (1-2), pp. 182 - 197 (2019)
The implication of early chromatin changes in X chromosome inactivation. Cell 113.
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73 (1), pp. 97 - 106 (2019)
Promoter distortion and opening in the RNA polymerase II cleft. Molecular Cell 114.
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Organization and regulation of gene transcription. Nature 115.
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Eukaryotic transcription turns 50. Cell 116.
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Structure of transcribing RNA polymerase II-nucleosome complex. Nature Communications 117.
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46 (21), pp. 11528 - 11538 (2018)
The APT complex is involved in non-coding RNA transcription and is distinct from CPF. Nucleic Acids Research 118.
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Transcription factor dimerization activates the p300 acetyltransferase. Nature 119.
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The interaction landscape between transcription factors and the nucleosome. Nature 120.
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25 (9), pp. 833 - 840 (2018)
RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 121.
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25 (9), pp. 754 - 765 (2018)
Structural basis of mitochondrial transcription. Nature Structural and Molecular Biology 122.
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560 (7720), pp. 607 - 612 (2018)
Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature 123.
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560 (7720), pp. 601 - 606 (2018)
Structure of paused transcription complex Pol II–DSIF–NELF. Nature 124.
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RNA velocity of single cells. Nature 125.
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Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin. Journal of Biological Chemistry 126.
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47, pp. 425 - 446 (2018)
Distinct mechanisms of transcription initiation by RNA polymerases I and II. Annual Review of Biophysics 127.
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47, pp. 17 - 22 (2017)
Conserved RNA polymerase II initiation complex structure. Current Opinion in Structural Biology 128.
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The structure of the COPI coat determined within the cell. eLife 129.
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171 (5), pp. 1072 - 1081 (2017)
Structural basis of mitochondrial transcription initiation. Cell 130.
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171 (5), pp. 1082 - 1093 (2017)
Mechanism of transcription anti-termination in human mitochondria. Cell 131.
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114 (46), pp. 12172 - 12177 (2017)
Mechanism of RNA polymerase II stalling by DNA alkylation. Proceedings of the National Academy of Sciences of the United States of America 132.
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551 (7679), pp. 204 - 209 (2017)
Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature 133.
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23 (11), pp. 1648 - 1659 (2017)
Cis-regulatory elements explain most of the mRNA stability variation across genes in yeast. RNA 134.
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Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature 135.
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6, e29736 (2017)
CDK9-dependent RNA polymerase II pausing controls transcription initiation. eLife 136.
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24 (10), pp. 809 - 815 (2017)
Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp. Nature Structural and Molecular Biology 137.
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13 (10), e1006664 (2017)
EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells. PLoS Pathogens 138.
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Structural molecular biology - A personal reflection on the occasion of John Kendrew's 100th birthday. Journal of Molecular Biology 139.
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118 (7), pp. 1741 - 1755 (2017)
MCPIP1 exogenous overexpression inhibits pathways regulating MYCN oncoprotein stability in neuroblastoma. Journal of Cellular Biochemistry 140.
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9 angstrom structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments. eLife 141.
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8, 15741 (2017)
Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex. Nature Communications 142.
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RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases. eLife 143.
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Core Mediator structure at 3.4 Å extends model of transcription initiation complex. Nature 144.
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Architecture of a transcribing-translating expressome. Science 145.
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66 (1), pp. 38 - 49 (2017)
Genome-wide analysis of RNA polymerase II termination at protein-coding genes. Molecular Cell 146.
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66 (6), pp. 77 - 88 (2017)
Spt5 plays vital roles in the control of sense and antisense transcription elongation. Molecular Cell 147.
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8, 14861 (2017)
The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA. Nature Communications 148.
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169 (1), pp. 120 - 131 (2017)
Structural basis of RNA polymerase I transcription initiation. Cell 149.
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TT-seq captures enhancer landscapes immediately after T-cell stimulation. Molecular Systems Biology 150.
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6, e23006 (2017)
Using the Volta phase plate with defocus for cryo-EM single particle analysis. eLife