Department of Molecular Biology Seminar Series: Genome architecture and transcription regulation in C. elegans
14:00 - 15:00
The Gurdon Institute, University of Cambridge
Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
Tower IV, Seminar Room, 2nd Floor
Prof. Dr. Patrick Cramer
All nuclear events take place in the context of chromatin, the organization of genomic DNA with histones and hundreds of associated proteins and RNAs. Chromatin is regulated at local and domain scale levels, directing nuclear processes such active and repressed transcription. Such regulation plays a central role in normal development and misregulation is associated with disease. I will discuss the partitioning of the genome into broad chromatin domains, activities of promoters and enhancers, and the analysis of interactions between regulatory elements genome-wide at high resolution.