Department of Molecular Biology Seminar Series: The mysterious world of Pol II CTD kinases
13:00 - 14:00
Sir William Dunn School of Pathology, University of Oxford
Max-Planck-Institut für biophysikalische Chemie (MPIBPC)
Tower IV, Seminar Room, 2nd Floor
Prof. Dr. Patrick Cramer
The carboxyl-terminal domain (CTD) of RNA polymerase II (pol II) is subject to multiple dynamic modifications during the transcription cycle, including phosphorylation by kinases. These CTD kinases are important for co-transcriptional RNA processing and control of elongation of transcription. We have been investigating the effects of short term inhibition of CTD kinases on transcription and CTD phosphorylation by mNET-seq and have uncovered new connections between transcription and RNA processing.