Theoretical and Computational Biophysics

Theoretical and Computational Biophysics

Our research aims at an understanding of the physics and function of proteins, protein complexes, and other biomolecular structures at the atomic level. For this purpose, complex computer simulations of the atomistic dynamics are carried out. Read more about our research projects at our RESEARCH website.

Register for the Theory Workshop 2024 in Hünfeld
The registration for the on-site participation in the Hünfeld Workshop 2024 has been closed on February 15, 2024. However, you can still register for online participation only until March 19, 2024. We are looking forward to see you all there - on-site and online! Follow this link to the workshop website with further information and the registration link... more

Open Positions

We are always looking for highly motivated scientists, possessing a strong background in physics, physical chemistry, mathematics and/or biomolecular simulations. If you are interested in driving research projects forward which are conducted at our department  please submit your application documents (including motivation letter, CV, publication list, certificates) preferrably as single PDF file via email to office.theor_comp_biophys@mpinat.mpg.de or follow the instructions in the job announcements.

Open PhD Position in the Godec Group
... in the field of “Theory of non-equilibrium stochastic many-body systems constrained by conservation laws” more
Open PhD or Postdoc Positions in the Grubmüller Group
... in the field of Theory and Methods for Non-equilibrium Atomistic Simulations of Complex Biomolecules in the research team of Helmut Grubmüller more
Open Postdoc Positions funded through a AVH fellowship within the Henritte Herz program
... in the research group of Aljaz Godec. Your application is most wecome! more

Our Research Groups


Helmut's scientific writing guidelines

Scientific Writing: The Art of Programming Brains
Struggling with writing your paper draft or thesis? Here’s advice my students found helpful over the years. It’s version 1.0 -- Comments, suggestions, corrections highly appreciated! more

Press releases & research news 

Research Group of Helmut Grubmüller

Helmut Grubmüller elected as member of the Leopoldina

The German National Academy of Sciences Leopoldina honors the biophysicist for his outstanding scientific achievements and the special expertise in his field of research. (in German) more

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Research Group of Bert de Groot

Discovery in Parkinson’s research: Lipids influence the formation of protein clumps

In Parkinson’s patients, alpha-synuclein proteins clump together to form fibrils, which presumably damage nerve cells. A research team has now shown how lipids bind to these fibrils and influence their arrangement. They also demonstrated how the drug candidate anle138b attaches to the lipidic fibrils. The findings could open up new diagnostic and therapeutic approaches. more

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Research Group of Aljaz Godec

Heating and cooling are fundamentally asymmetric

If you take a coin out of an ice bath, it warms up over time. Likewise, a hot coin that you have just taken out of a sauna cools down. The fact that systems, here the coin, thermally adapt to their environment is due to the heat flow that results from temperature differences. more

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